- The mechanism of phospholipase C-gamma1 regulation
-
Kim MJ, Kim EK, Ryu SH, Suh PG
- KMID: 755072
- Exp Mol Med.
- 2000 Sep;32(3):101-109.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while... -
- CITED
-
- Close
- SHARE
-
- Close
- Co-activation of Gi and Gq proteins exerts synergistic effect on human platelet aggregation through activation of phospholipase C and Ca2+ signalling pathways
-
Shah BH, Siddiqui A, Qureshi KA, Khan M, Rafi S, Ujan VA, Yakoob MY, Rasheed H, Saeed SA
- KMID: 755026
- Exp Mol Med.
- 1999 Mar;31(1):42-46.
Our previous studies have shown that subthreshold concentrations of two platelet agonists exert synergistic effects on platelet aggregation. Here we studied the mechanism of synergistic interaction of 5-hydroxytryptamine (5-HT) and epinephrine mediated platelet... -
- CITED
-
- Close
- SHARE
-
- Close
- EGF-stimulated aldosterone secretion is mediated by tyrosine phosphorylation but not by phospholipase C in cultured porcine adrenal glomerulosa cells
-
Kim SY, Park DJ, Lee HK
- KMID: 1038444
- J Korean Med Sci.
- 1998 Dec;13(6):629-637.
- doi: 10.3346/jkms.1998.13.6.629
We examined the effect of EGF and angiotensin II (AII) on the formation of inositol phosphates and aldosterone secretion, and observed the role of tyrosine phosphorylation in EGF or... -
- CITED
-
- Close
- SHARE
-
- Close
- The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells
-
Kim YD, Bae YS, Park JC, Suh PG, Ryu SH
- KMID: 1457539
- Exp Mol Med.
- 2001 Dec;33(4):257-262.
His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+]i) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of... -
- CITED
-
- Close
- SHARE
-
- Close
- Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
-
Chung BH, Kim S, Kim JD, Lee JJ, Baek YY, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM
- KMID: 1245262
- Exp Mol Med.
- 2012 Mar;44(3):191-201.
- doi: 10.3858/emm.2012.44.3.014
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in vascular functions, including vasorelaxation. We here investigated the pharmacological effect of the natural product syringaresinol on... -
- CITED
-
- Close
- SHARE
-
- Close
