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Effect of Phosphodiesterase-5 Inhibitors on the Treatment of Male Infertility: A Systematic Review and Meta-Analysis

Dong L, Zhang X, Yan X, Shen Y, Li Y, Yu X

Purpose: Male infertility is a worldwide problem with limitations in the treatment. Phosphodiesterase-5 inhibitors (PDE5is) is the first choice for the treatment of erectile dysfunction, more and more studies show...
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Molecular and Histologic Evidence of Novel Erectile Dysfunction Rat Model as an Aging Atherosclerosis Model: A Preliminary Study

Kim JH, Shim JS, Kim JW, Doo SW, Bae JH, Lee JH, Song YS, Kim JJ, Moon DG

Purpose: To validate a novel arteriogenic erectile dysfunction (ED) model with atherosclerosis (AS) based on molecular and histologic evidence induced by chronic pelvic ischemia (CPI) and determine effect of phosphodiesterase-5...
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No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

Wang JZ, Le S, Alexanian , Boddu S, Merleev A, Marusina A, Maverakis

PURPOSE: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene...
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A current perspective on post-micturition dribble in males

Yang DY, Lee WK

Post-micturition dribble (PMD) is the involuntary loss of urine immediately after urination. It is classified as a post-micturition symptom and is more common in males. Traditionally, PMD has been considered...
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Obesity and Erectile Dysfunction: From Bench to Clinical Implication

Moon KH, Park SY, Kim YW

Obesity is a major public health issue worldwide and is frequently associated with erectile dysfunction (ED). Both conditions may share an internal pathologic environment, also known as common soil. Their...
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Acute Hemodynamic Changes after Single Administration of Udenafil in Pulmonary Arterial Hypertension: a Phase IIa Study

Chang SA, Kim HK, Chang HJ, Kim DK

BACKGROUND AND OBJECTIVES: Udenafil, a new phosphodiesterase-5 inhibitor (PDE5i), has been used to treat erectile dysfunction. Given the proven benefit of PDE5i in pulmonary arterial hypertension (PAH), we evaluated serial...
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A Case of Sexual Enhancer Induced Fixed Drug Eruption

Lee SK, Kim DJ, Suh JH, Kim MS, Lee UH

  • KMID: 2436688
  • Korean J Dermatol.
  • 2018 May;56(4):269-272.
Fixed drug eruption is a commonly reported mucocutaneous drug eruption. A 61-year-old male presented to our clinic with a complaint of an itchy round erythematous patch on the left hand...
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Safety and Effectiveness of Once-Daily Tadalafil (5 mg) Therapy in Korean Men with Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms in a Real-World Clinical Setting: Results from a Post-Marketing Surveillance Study

Won JE, Chu JY, Choi HC, Chen Y, Park HJ, Dueñas HJ

PURPOSE: The aim of this study was to investigate the safety and effectiveness of tadalafil 5 mg once daily (quaque die [everyday], QD) among Korean men with benign prostatic hyperplasia...
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A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Therapeutic Confirmatory Study to Evaluate the Safety and Efficacy of Avanafil in Korean Patients with Erectile Dysfunction

Park HJ, Kim SW, Kim JJ, Lee SW, Paick JS, Ahn TY, Park K, Park JK, Park NC

A multi-center, randomized, double-blind, placebo-controlled study was conducted with 158 subjects who were randomized to placebo or avanafil 50, 100, and 200 mg on demand for 8 weeks to evaluate...
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Efficacy of phosphodiesterase type 5 inhibitors for the treatment of distal ureteral calculi: A systematic review and meta-analysis

Montes Cardona CE, García-Perdomo HA

PURPOSE: To determine the efficacy of phosphodiesterase type 5 inhibitors (PDE5i) as medical expulsive therapy (MET) for the treatment of distal ureteral calculi. MATERIALS AND METHODS: A search strategy was conducted...
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Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway

Choi BR, Kim HK, Park JK

PURPOSE: The objective of this study was to evaluate the relaxant effect of scoparone from Artemisia capillaris on rabbit penile corpus cavernosum smooth muscle (PCCSM) and to elucidate the mechanism...
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Postprostatectomy Erectile Dysfunction: A Review

Capogrosso P, Salonia A, Briganti A, Montorsi F

In the current era of the early diagnosis of prostate cancer (PCa) and the development of minimally invasive surgical techniques, erectile dysfunction (ED) represents an important issue, with up to...
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Recreational Use of Phosphodiesterase 5 Inhibitors and Its Associated Factors among Undergraduate Male Students in an Ethiopian University: A Cross-Sectional Study

Gebreyohannes EA, Bhagavathula AS, Gebresillassie BM, Tefera YG, Belachew S, Erku DA

PURPOSE: To assess the prevalence of phosphodiesterase 5 (PDE5) inhibitor use and associated factors among University of Gondar undergraduate students. MATERIALS AND METHODS: An institution-based, cross-sectional study, using a survey questionnaire,...
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The risk factors, diagnosis and treatment guideline of erectile dysfunction

Moon DG

Erectile dysfunction (ED) can negatively impact the quality of life among men, and increasingly affects all age strata. This has led to an explosion of health information on ED both...
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Mirodenafil Prevents Bladder Dysfunction Induced by Chronic Bladder Ischemia in Rats

Choi H, Bae JH, Shim JS, Park JY, Moon DG, Lee JG

PURPOSE: To investigate the protective effect of mirodenafil on bladder function in a rat model of chronic bladder ischemia (CBI). METHODS: Twenty-four Sprague-Dawley rats were randomized to three groups: untreated, sham-operated...
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A Meta-Analysis of Long- Versus Short-Acting Phosphodiesterase 5 Inhibitors: Comparing Combination Use With alpha-Blockers and alpha-Blocker Monotherapy for Lower Urinary Tract Symptoms and Erectile Dysfunction

Choi H, Kim HJ, Bae JH, Kim JH, Moon DG, Cheon J, Yeo JK

PURPOSE: Combination therapy with an alpha-1-adrenergic blocker and phosphodiesterase type 5 inhibitors (PDE5Is) has shown improvements in lower urinary tract symptoms (LUTS) with negligible side effects. Nonetheless, decisive advantages in...
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The Prescribing and Dispensing of Phosphodiesterase Type 5 Inhibitors in South Korea: A Questionnaire Survey of Patient Discomfort

Kim SW, Kim JW, Chae JY, Kim JW, Yoon CY, Oh MM, Park HS, Kim JJ, Moon DG

PURPOSE: This study was performed to investigate the discomfort reported by patients taking phosphodiesterase type 5 inhibitors (PDE5Is) in clinical practice. MATERIALS AND METHODS: From September 2011 to March 2012, we...
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Mirodenafil for the Treatment of Erectile Dysfunction: A Systematic Review of the Literature

Park HJ, Moon KH, Lee SW, Lee WK, Kam SC, Lee JH, Park NC

  • KMID: 2320806
  • World J Mens Health.
  • 2014 Apr;32(1):18-27.
Phosphodiesterase type 5 (PDE5) inhibitors are the most commonly used treatment for erectile dysfunction (ED). Since the launch of sildenafil, several drugs-including mirodenafil, sildenafil citrate (sildenafil), tadalafil, vardenafil HCL (vardenafil),...
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The Efficacy of Mirodenafil for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Middle-Aged Males

Kong DH, Yun CJ, Park HJ, Park NC

PURPOSE: The aim of this study was to investigate the efficacy of mirodenafil in middle-aged male patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). MATERIALS AND METHODS: Eighty-eight males with CP/CPPS...
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Low-Intensity Shock Wave Therapy and Its Application to Erectile Dysfunction

Lei H, Liu J, Li H, Wang L, Xu Y, Tian W, Lin G, Xin Z

  • KMID: 2320816
  • World J Mens Health.
  • 2013 Dec;31(3):208-214.
Although phosphodiesterase type 5 inhibitors (PDE5Is) are a revolution in the treatment of erectile dysfunction (ED) and have been marketed since 1998, they cannot restore pathological changes in the penis....
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