- Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
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Shin DH, Kim OH, Jun HS, Kang MK
- KMID: 1104802
- Exp Mol Med.
- 2008 Oct;40(5):486-494.
- doi: 10.3858/emm.2008.40.5.486
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient of red pepper, has been reported to possess anti-carcinogenic and anti-mutagenic activities. In this study, the anti-migration activity of capsaicin on highly metastatic B16-F10... -
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- Angiotensin II-induced aortic ring constriction is mediated by phosphatidylinositol 3-kinase/L-type calcium channel signaling pathway
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Do KH, Kim MS, Kim JH, Rhim BY, Lee WS, Kim CD, Bae SS
- KMID: 1119322
- Exp Mol Med.
- 2009 Aug;41(8):569-576.
- doi: 10.3858/emm.2009.41.8.062
Angiotensin II (AngII) is a crucial hormone that affects vasoconstriction and exerts hypertrophic effects on vascular smooth muscle cells. Here, we showed that phosphatidylinositol 3-kinase-dependent calcium mobilization plays pivotal roles... -
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- Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
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Oh SY, Park KS, Kim AJ, Choi KY
- KMID: 1093594
- Exp Mol Med.
- 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,... -
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- IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species
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Paek AR, Kim SH, Kim SS, Kim KT, You HJ
- KMID: 964664
- Exp Mol Med.
- 2010 Oct;42(10):696-702.
- doi: 10.3858/emm.2010.42.10.068
Expression of zinc-finger protein 143 (ZNF143), a human homolog of the Xenopus transcriptional activator protein Staf, is induced by various DNA-damaging agents including etoposide, doxorubicin, and gamma-irradiation. ZNF143 binds to... -
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- Interleukin-1 beta Induces MUC2 Gene Expression and Mucin Secretion via Activation of PKC-MEK/ERK,and PI3K in Human Airway Epithelial Cells
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Kim YD, Jeon JY, Woo HJ, Lee JC, Chung JH, Song SY, Yoon SK, Baek SH
- KMID: 648785
- J Korean Med Sci.
- 2002 Dec;17(6):765-771.
- doi: 10.3346/jkms.2002.17.6.765
Interleukin 1 beta (IL-1 beta), a proinflammatory cytokine, is related with inflammatory diseases and it up-regulates MUC2 gene expression and mucin secretion. This study was designed to investigate the... -
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- COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells
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Choi EM, Kwak SJ, Kim YM, Ha KS, Kim JI, Lee SW, Han JA
- KMID: 1056232
- Exp Mol Med.
- 2005 Jun;37(3):199-203.
Cyclooxygenase-2 (COX-2) has been reported to be associated with tumor development and progression as well as to protect cells from apoptosis induced by various cellular stresses. Through a tetracycline-regulated COX-2... -
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