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Repeated Exposure to beta-phenylethylamine Produces Locomotor Sensitization to Amphetamine, but Not Vice Versa, in the Rat

Park HK, Na JC, Jang JK, Kim JH

Repeated administration of amphetamine (AMPH) produces behavioral sensitization, a proposed model for the escalation of drug use characteristic of human addicts. beta-Phenylethylamine (PEA) is an endogenous trace amine found in...
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Caffeine-induced endothelial cell death and the inhibition of angiogenesis

Li H, Jin SY, Son HJ, Seo JH, Jeong GB

Numerous studies have shown that adenosine or adenosine agonists can stimulate angiogenesis. However, the effect of caffeine (a known adenosine receptor antagonist) on angiogenesis has not been previously studied. Accordingly,...
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The Evaluation of Otilonium Bromide Treatment in Asian Patients With Irritable Bowel Syndrome

Chang FY, Lu CL, Luo JC, Chen TS, Chen MJ, Chang HJ

  • KMID: 2325842
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):402-410.
BACKGROUND/AIMS: Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to...
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Comparison of inodilator effect of higenamine, YS49, YS51, tetra-hydroisoquinoline analogs, and dobutamine in the rat

Chong WS, Lee YS, Kang YJ, Lee DH, Ryu JC, Yun-Choi H, Chang KC

  • KMID: 1849840
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):323-330.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series...
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Pharmacological characterization of synthetic tetrahydroisoquinoline alkaloids, YS 51 and YS 55, on the cardiovascular system

Chang KC, Kang YJ, Lee YS, Chong WS, Yun-Choi H, Lee DH, Ryu JC

  • KMID: 2285209
  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):461-469.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions...
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