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The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?

Michelucci A, Chiappetta C, Cacciotti , Veccia N, Astri E, Leopizzi M, Prosperi Porta R, Petrozza V, Della Rocca C, Bevilacqua G, Cavazzana , Di Cristofano C

  • KMID: 2053513
  • Gut Liver.
  • 2013 Jan;7(1):35-40.
BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes constitutive receptor activation leading to the development and growth of tumors;...
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