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A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model

Park I, Hong S, Hwang Y, Kim P

Longitudinal imaging of murine pancreas is technically challenging due to the mechanical softness of the tissue influenced by peristalsis. Here, we report a novel pancreatic imaging window for long-term stabilized...
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Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives

Lin S, Li H, Fang X

  • KMID: 2460478
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):499-507.
  • doi: 10.5056/jnm19081
Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of...
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Early Phase of Achalasia Manifested as an Esophageal Subepithelial Tumor

Lee JH, Lee YJ, Lee JM, Ju MJ, Yang MA, Choi MW, Yun SH

The Chicago classification (CC) defines an esophagogastric junction outflow obstruction (EGJOO) as the presence of several instances of intact or weak peristalsis, elevated median integrated relaxation pressure above 15 mmHg,...
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Management of Achalasia: Expert Consensus Statements

Choe AR, Jung HK

Achalasia is a motility disorder of the esophagus characterized by absence of peristalsis and failure of relaxation of lower esophagus sphincter. The introduction of high resolution manometry (HRM) and per-oral...
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High-resolution Manometry Findings During Solid Swallows Correlate With Delayed Reflux Clearance and Acid Exposure Time in Non-erosive Reflux Disease Patients

Ribolsi M, Biasutto D, Giordano A, Balestrieri P, Cicala M

  • KMID: 2433499
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):68-74.
  • doi: 10.5056/jnm18054
BACKGROUND/AIMS: The role of esophageal motility in determining gastroesophageal reflux disease (GERD) severity has not been completely evaluated. A few studies have investigated high-resolution manometry (HRM) patterns during solid swallows....
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Assessment of Esophageal Motor Disorders Using High-resolution Manometry in Esophageal Dysphagia With Normal Endoscopy

Wang D, Wang X, Yu Y, Xu X, Wang J, Jia Y, Xu H

  • KMID: 2433498
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):61-67.
  • doi: 10.5056/jnm18042
BACKGROUND/AIMS: The distribution and esophageal motor characteristics of Chinese patients with esophageal dysphagia who exhibit no structural abnormalities on esophagogastroduodenoscopy remain unclear. Our aim is to assess the esophageal motor...
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Effect of antispasmodic agents for the treatment of irritable bowel syndrome

Lee SH, Jee SR

Antispasmodics are effective in reducing abdominal pain and controlling spasm. Irritable bowel syndrome (IBS) patients have characteristic key factors such as intestinal motility disorder and visceral hypersensitivity. So antispasmodics have...
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Axial Movements and Length Changes of the Human Lower Esophageal Sphincter During Respiration and Distension-induced Secondary Peristalsis Using Functional Luminal Imaging Probe

Liao D, Lottrup C, Fynne L, McMahon BP, Krogh K, Drewes AM, Zhao J, Gregersen

  • KMID: 2413102
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):255-267.
  • doi: 10.5056/jnm17084
BACKGROUND/AIMS: Efficient transport through the esophago-gastric junction (EGJ) requires synchronized circular and longitudinal muscle contraction of the esophagus including relaxation of the lower esophageal sphincter (LES). However, there is a...
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Acotiamide Has No Effects on Esophageal Motor Activity or Esophagogastric Junction Compliance

Mikami H, Ishimura N, Okada M, Izumi D, Okimoto E, Ishihara S, Kinoshita

  • KMID: 2413100
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):241-247.
  • doi: 10.5056/jnm16111
BACKGROUND/AIMS: The novel prokinetic drug acotiamide is used for treatment of functional dyspepsia. It is still unclear how acotiamide has effects on esophageal motor function. Esophageal peristalsis and esophagogastric junction...
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Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett's Esophagus

Bazin C, Benezech A, Alessandrini M, Grimaud JC, Vitton V

  • KMID: 2413097
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):216-225.
  • doi: 10.5056/jnm17090
BACKGROUND/AIMS: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett's esophagus (BE) is controversial. Our objective...
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A computational model of ureteral peristalsis and an investigation into ureteral reflux

Hosseini G, Ji C, Xu D, Rezaienia , Avital E, Munjiza A, Williams J, Green JS

The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological...
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Factors Determining the Inter-observer Variability and Diagnostic Accuracy of High-resolution Manometry for Esophageal Motility Disorders

Kim JH, Kim SE, Cho YK, Lim CH, Park MI, Hwang JW, Jang JS, Oh M, Motility Study Club of Korean Society of Neurogastroenterology and Motility

  • KMID: 2417273
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):58-69.
  • doi: 10.5056/jnm17064
BACKGROUND/AIMS: Although high-resolution manometry (HRM) has the advantage of visual intuitiveness, its diagnostic validity remains under debate. The aim of this study was to evaluate the diagnostic accuracy of HRM...
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The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine

Kim NH, Park JH, Park JS, Joung YH

  • KMID: 2395430
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):606-615.
  • doi: 10.5056/jnm16201
BACKGROUND/AIMS: Bile acid is an important luminal factor that affects gastrointestinal motility and secretion. We investigated the effect of bile acid on secretion in the proximal and distal rat colon...
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Understanding the Chicago Classification: From Tracings to Patients

Schlottmann F, Herbella F, Patti MG

  • KMID: 2395416
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):487-494.
  • doi: 10.5056/jnm17026
Current parameters of the Chicago classification include assessment of the esophageal body (contraction vigour and peristalsis), lower esophageal sphincter relaxation pressure, and intra-bolus pressure pattern. Esophageal disorders include achalasia, esophagogastric...
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Emergency ultrasonography of the gastrointestinal tract of children

Hwang JY

Ultrasonography (US) is widely used to evaluate most body parts in pediatric patients because it is simple, noninvasive, easy to use, and applicable in a wide variety of clinical situations....
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A Case of Esophageal Achalasia Misconceived as Laryngopharyngeal Reflux Disease

Noh SH, Lee YW, Park JS, Lee SH

Laryngopharyngeal reflux disease (LPRD) is common in laryngologic practice. In Korea, up to 1 out of every 5 patients who visit otorhinolaryngology clinic is supposed to have LPRD with symptoms...
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The Effect of Anti-reflux Therapy on Patients Diagnosed with Minor Disorders of Peristalsis in High-resolution Manometry

Jeong J, Kim SE, Park MI, Park SJ, Moon W, Kim JH, Jung K, Choi YJ, Lee JY, Lee YD

BACKGROUND/AIMS: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy...
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High-resolution Manometry in Patients with Gastroesophageal Reflux Disease Before and After Fundoplication

Rerych K, Kurek J, Klimacka-Nawrot E, Błońska-Fajfrowska B, Stadnicki

  • KMID: 2367456
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):55-63.
  • doi: 10.5056/jnm16062
BACKGROUND/AIMS: The study aimed to determine pre- and post-fundoplication esophagogastric junction (EGJ) pressure and esophageal peristalsis by high-resolution manometry (HRM) in patients with gastroesophageal reflux disease (GERD). METHODS: Pre-operative and post-operative...
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Per Oral Endoscopic Myotomy in Children with Achalasia Cardia

Nabi Z, Ramchandani M, Reddy DN, Darisetty , Kotla R, Kalapala R, Chavan R

  • KMID: 2433453
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):613-619.
  • doi: 10.5056/jnm15172
BACKGROUND/AIMS: Achalasia cardia (AC) is a motility disorder, characterized by impaired lower esophageal sphincter relaxation and absence of esophageal peristalsis. AC is rare in children with unclear optimum management strategies....
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Role of Mixed Reflux and Hypomotility with Delayed Reflux Clearance in Patients with Non-cardiac Chest Pain

Ribolsi M, Balestrieri P, Biasutto D, Emerenziani S, Cicala M

  • KMID: 2433452
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):606-612.
  • doi: 10.5056/jnm15182
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is the most common cause of non-cardiac chest pain (NCCP). Currently available data reveal a weak relationship between NCCP and dysmotility. Moreover, it is unclear...
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