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Inflammatory cytokines in midbrain periaqueductal gray contribute to diabetic induced pain hypersensitivity through phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway

Guo M, Jiang Z, Chen Y, Wang F, Wang Z

Background: Diabetes-related neuropathic pain frequently occurs, and the underpinning mechanism remains elusive. The periaqueductal gray (PAG) exhibits descending inhibitory effects on central pain transmission. The current work aimed to examine...
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Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain

Hosseini M, Parviz M, Shabanzadeh AP, Zamani E

Study Design: In this study, we decided to change the activity of periaqueductal gray (PAG)'s metabotropic glutamate receptors subtype 8 (mGluR8) by means of its specific agonist, (S)-3,4-dicarboxyphenylglycine (DCPG), and...
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Past, Present, and Future in the Study of Neural Control of the Lower Urinary Tract

Kim JW, Kim SJ, Park JM, Na YG, Kim KH

The neurological coordination of the lower urinary tract can be analyzed from the perspective of motor neurons or sensory neurons. First, sensory nerves with receptors in the bladder and urethra...
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Magnetic Resonance Image Texture Analysis of the Periaqueductal Gray Matter in Episodic Migraine Patients without T2-Visible Lesions

Chen Z, Chen X, Liu M, Liu S, Yu S, Ma L

OBJECTIVE: The periaqueductal gray matter (PAG), a small midbrain structure, presents dysfunction in migraine. However, the precise neurological mechanism is still not well understood. Herein, the aim of this study...
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Distribution Patterns of Calbindin-D28K and NADPH-Diaphorase Positive Neurons in the Midbrain Periaqueductal Gray of the Rabbit

Oh HJ, Kim SH, Kim HR, Park SH, Park SH, Shin HR, Jung SY, Lee MI

  • KMID: 2341937
  • J Korean Neuropsychiatr Assoc.
  • 2011 May;50(3):228-235.
OBJECTIVES: We attempted to compartmentalize the periaqueductal gray (PAG) of the rabbit in terms of the different distribution patterns between NADPH-diaphorase (NADPHd)- and calbindin D28K (CB)-positive neurons. METHODS: Immunohistochemistry and immunofluorescent...
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Effects of Herbal Bath "HAC" on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Sciatic Crushed Nerve Injury in Rats

Ryu MS, Lim HH, Song YK, Lee HJ, Seo JH, Lee MH, Shin MS, Kim CJ

Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. c-Fos expression is sometimes used as a marker of increased...
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Modulation of Amygdalin on Glycine- and Glutamate-induced Ion Currents in Rat Periaqueductal Gray Neurons

Lee GJ, Lim HH, Song YK, Shin MC, Shin MS, Kim CJ

Amygdalin is known as vitamain B17, and it was called laetrile. Amygdalin is composed of two molecules of glucose, one molecule of benzaldehyde which induces an analgesic action, and one...
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Inhibitory Mechanism of Periaqueductal Gray Matter on Neuropathic Pain in Rat

Kim BO, Ryu JW, Seo JS, Sohn JH

  • KMID: 2174649
  • J Korean Acad Rehabil Med.
  • 2001 Feb;25(1):110-116.
OBJECTIVE: Using Lee et al (1996) model, we assessed the effect of opioid within the PAG on the manifestations of the neuropathic pain, and we studied the effects of naloxone...
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A Case of Midbrain Hemorrhage Presenting as Bilateral Ptosis with Diurnal Fluctuation

Son IH, Suk SH

  • KMID: 2342805
  • J Korean Neurol Assoc.
  • 2000 May;18(3):326-329.
A 54 year-old woman presented with bilateral fatigable blepharoptosis with diurnal fluctuation and diplopia for 10 days. She had a 3 year history of hypertension and showed symptoms of bilateral...
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Distribution of Neuropeptide mRNA-Containing Neurons and Changes of Their Gene Expression in the Rat Periaqueductal Gray in a Neuropathic Pain Model

Huh SM, Kim JG, Bae MA, Kim DS, Park MJ, Jo HJ

  • KMID: 1529457
  • Korean J Anat.
  • 1997 Jun;30(3):205-214.
The distribution of enkephalin, dynorphin, substance P and neurotensin in the periaqueductal gray[PAG] has been well established by immunohistochemical methods. However, there is little information about the regional distribution of...
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