- Neuronal autophagy and neurodegenerative diseases
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Son JH, Shim JH, Kim KH, Ha JY, Han JY
- KMID: 1120127
- Exp Mol Med.
- 2012 Feb;44(2):89-98.
- doi: 10.3858/emm.2012.44.2.031
Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. The integrity of postmitotic neurons is heavily dependent on high basal... -
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- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
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Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ
- KMID: 1104391
- Exp Mol Med.
- 2011 Apr;43(4):216-222.
- doi: 10.3858/emm.2011.43.4.026
Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have... -
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- A Rat Model of Striatonigral Degeneration Generated by Simultaneous Injection of 6-Hydroxydopamine into the Medial Forebrain Bundle and Quinolinic Acid into the Striatum
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Yoon HH, Kim YH, Shin ES, Jeon SR
- KMID: 2069939
- J Korean Med Sci.
- 2014 Nov;29(11):1555-1561.
- doi: 10.3346/jkms.2014.29.11.1555
A double toxin-double lesion strategy is well-known to generate a rat model of striatonigral degeneration (SND) such as multiple system atrophy-parkinsonian type. However, with this model it is difficult to... -
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