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Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades

Taboada AGM, Lominchar PL, Roman LM, García-Alfonso P, Martin AJM, Rodriguez JAB, Pascual JMA

In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in...
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Human equilibrative nucleoside transporter-1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression; do they have survival impact to pancreatic cancer?

Hwang DW, Shin E, Cho JY, Han HS, Yoon YS

Backgrounds/Aims: Gemcitabine is still one of adjuvant options in chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC). Integral membrane transporter protein and intracellular enzymes including human equilibrative nucleoside transporter 1 (hENT1),...
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Factors of Endoscopic Ultrasound-Guided Tissue Acquisition for Successful Next-Generation Sequencing in Pancreatic Ductal Adenocarcinoma

Park JK, Lee JH, Noh DH, Park JK, Lee KT, Lee JK, Lee KH, Jang KT, Cho J

Background/Aims: Recent advances in understanding the genetics of pancreatic ductal adenocarcinoma (PDAC) have led to the potential for a personalized approach. Several studies have described the feasibility of generating genetic...
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Clinical importance of preoperative and postoperative prognostic nutritional index in patients with pancreatic ductal adenocarcinoma

Ikeguchi M, Goto K, Watanabe J, Urushibara S, Osaki T, Endo K, Tatebe S, Nakamura S

BACKGROUNDS/AIMS: The prognostic nutritional index (PNI) is based on the albumin concentration and absolute lymphocyte count and is designed to assess the nutritional and immunological status of patients. In this...
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Identifying the role of neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio as prognostic markers in patients undergoing resection of pancreatic ductal adenocarcinoma

Giakoustidis A, Neofytou K, Costa Neves M, Giakoustidis D, Louri E, Cunningham D, Mudan S

BACKGROUNDS/AIMS: It is important to point out that the identification of inflammation is an essential component of the pathogenesis and the progression of cancer. In this study, we analysed the...
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Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer

Wang SQ, Liu Y, Yao MY, Jin J

Identifying a target molecule that is crucially involved in pancreatic tumor growth and metastasis is necessary in developing an effective treatment. The study aimed to investigate the role of the...
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Contrast-enhanced endoscopic ultrasound for pancreatobiliary disease

Tang RS

Endoscopic ultrasound (EUS), with or without fine needle aspiration (FNA), has become an essential tool in the evaluation of pancreatobiliary diseases. Although conventional EUS is superior to multidetector computed tomography...
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Clinical role of contrast-enhanced harmonic endoscopic ultrasound in differentiating pancreatic solid lesions

Shim CS, Lee TY, Cheon YK

Accurate diagnosis of pancreatic solid lesions is often difficult using conventional imaging modalities. With the recent introduction of contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS), it is now possible to evaluate the...
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Differentiating Pancreatic Ductal Adenocarcinoma from Pancreatic Serous Cystadenoma, Mucinous Cystadenoma, and a Pseudocyst with Detailed Analysis of Cystic Features on CT Scans: a Preliminary Study

Lv P, Mahyoub R, Lin X, Chen K, Chai W, Xie J

OBJECTIVE: To determine whether or not detailed cystic feature analysis on CT scans can assist in the differential diagnosis of pancreatic ductal adenocarcinoma (PDAC) from serous cystadenoma (SCN), mucinous cystadenoma...
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Precursor Lesions of Pancreatic Cancer

Yonezawa S, Higashi M, Yamada N, Goto M

  • KMID: 2053356
  • Gut Liver.
  • 2008 Dec;2(3):137-154.
This review article describes morphological aspects, gene abnormalities, and mucin expression profiles in precursor lesions such as pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm...
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Two Cases of Pancreatic Ductal Adenocarcinoma, Manifested as Solid Pseudopapillary Tumor and Intraductal Papillary Mucinous Neoplasm

Kim DH, Cho JH, Lee SH, Kim HK, Bang SM, Song SY, Chung JB, Park SW

  • KMID: 782978
  • Korean J Gastroenterol.
  • 2008 Feb;51(2):142-146.
Compared with other types of cancers, pancreatic cancer is one of the most dreadful malignancies and is fifth leading cause of cancer-related death in Korea. It is difficult to expect...
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Clinical Features and Outcomes of Invasive Intraductal Papillary Mucinous Neoplasm: Comparison with Pancreatic Ductal Adenocarcinoma

Paik KY, Jung JC, Heo JS, Choi SH, Choi DW, Kim YI

  • KMID: 2211065
  • J Korean Surg Soc.
  • 2007 Apr;72(4):270-275.
PURPOSE: Histologically, IPMN (intraductal papillary mucinous neoplasm) includes various grades of lesion, from hyperplasia and adenoma to adenocarcinoma. The prognosis is different for each histological grade. The malignant IPMN contain...
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