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Mutations of p53 associated with pancreatic cancer and therapeutic implications

Voutsadakis IA

Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis. Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease is invariably fatal with survival time less than...
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Gemcitabine and Erlotinib with or without Oxaliplatin in Previously Untreated Advanced Pancreatic Cancer: A Randomized Phase II Trial

Lim SH, Yun J, Lee MY, Kim HJ, Kim KH, Kim SH, Lee SC, Bae SB, Kim CK, Lee N, Lee KT, Park SK, Lee YN, Moon JH

Purpose: Erlotinib has been the only targeted agent to show significantly improved outcomes in pancreatic adenocarcinoma when combined with gemcitabine. We aimed to evaluate whether the addition of oxaliplatin to...
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Impact of diabetes mellitus on morbidity and survival after pancreaticoduodenectomy for malignancy

Deo KB, Kulkarni AA, Kumar-M P, Krishnamurthy G, Shenvi S, Rana SS, Kapoor R, Gupta R

Backgrounds/Aims: Diabetes mellitus (DM) is a known risk factor for morbidity, length of hospital stay, or mortality after surgery, however, its impact on postoperative course and long-term survival after pancreaticoduodenectomy...
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Updates of Chemotherapy and Radiotherapy for Pancreatic Cancer

Sung MJ, Bang S

Pancreatic cancer is still one of the most aggressive malignancy, showing 10% of 5-year survival. Among the several reasons of the grave prognosis, the poor response to chemotherapeutic agents and...
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Percutaneous Radiofrequency Ablation for Metachronous Hepatic Metastases after Curative Resection of Pancreatic Adenocarcinoma

Lee SJ, Kim JH, Kim SY, Won HJ, Shin YM, Kim PN

OBJECTIVE: To retrospectively evaluate the safety and efficacy of percutaneous radiofrequency ablation (RFA) in patients with metachronous hepatic metastases arising from pancreatic adenocarcinoma who had previously received curative surgery. MATERIALS AND...
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Prognostic value of COL6A3 in pancreatic adenocarcinoma

Svoronos C, Tsoulfas G, Souvatzi M, Chatzitheoklitos E

BACKGROUNDS/AIMS: Pancreatic cancer is one of the most fatal human malignancies with poor prognosis, despite advances in therapy. Here, we evaluated the potential role of collagen type VI α3 chain...
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Impact of BRCA1/2 gene mutations on survival of patients with pancreatic cancer: A case-series analysis

Navarro EB, López EV, Quijano Y, Caruso R, Ferri V, Durand H, Cabrera IF, Reques ED, Ielpo B, Glagolieva AY, Plaza C

BRCA gene mutations are found in up to 10% of pancreatic adenocarcinoma cases. We present a description of 4 cases along with a review of the current literature regarding pathogenesis,...
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Contemporary management of borderline resectable pancreatic ductal adenocarcinoma

Lekka K, Tzitzi E, Giakoustidis A, Papadopoulos V, Giakoustidis D

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive tumors, with a low rate of survival, likely due to the tendency of the tumor for early local and distant...
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A Case of Agenesis of the Dorsal Pancreas with Concomitant Pancreatic Ductal Adenocarcinoma in an Adult Patient

Park JE, Jung SY, Lee JY, Lee EH, Goag EK, Lee SH, Cha BH

Agenesis of dorsal pancreas (ADP) is an extremely rare congenital anomaly defined as an absence of the dorsal ductal system resulting from failure in the embryologic development of the pancreatic...
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Inflammation and Cancer Development in Pancreatic and Biliary Tract Cancer

Lee SH, Park SW

Chronic inflammation has been known to be a risk for many kinds of cancers, including pancreatic and biliary tract cancer. Recently, inflammatory process has emerged as a key mediator of...
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RE: Atypical Pulmonary Metastases from Pancreatic Adenocarcinoma

Virgilio E, Iannicelli E, Balducci G

No abstract available.
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Is a Preoperative Assessment of the Early Recurrence of Pancreatic Cancer Possible after Complete Surgical Resection?

La Torre M, Nigri G, lo Conte A, Mazzuca F, Tierno SM, Salaj A, Marchetti , Ziparo V, Ramacciato G

  • KMID: 1774535
  • Gut Liver.
  • 2014 Jan;8(1):102-108.
BACKGROUND/AIMS: The prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a prognostic indicator of recurrence and reduced overall survival....
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Transcatheter Arterial Chemoembolization for Hepatic Recurrence after Curative Resection of Pancreatic Adenocarcinoma

Kim JH, Choi EK, Yoon HK, Ko GY, Sung KB, Gwon DI

  • KMID: 1974142
  • Gut Liver.
  • 2010 Sep;4(3):384-388.
BACKGROUND/AIMS: Despite curative resection, hepatic recurrences cause a significant reduction in survival in patients with primary pancreatic adenocarcinoma. Transcatheter arterial chemoembolization (TACE) has recently been used successfully to treat primary...
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Prognostic Factors and Survival Rate of Pancreatic Adenocarcinoma after Curative Surgery

Chang HJ, Lee JG, Kang CM, Kim KS, Choi JS, Kim BR, Lee WJ

  • KMID: 2145103
  • J Korean Surg Soc.
  • 2005 Aug;69(2):152-156.
PURPOSE: This retrospective study aimed to identify the outcomes of resected pancreatic cancers and determine the prognostic factors for long term survival based on a single hospital experience. METHODS: Between...
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Significance of Tumor Angiogenesis and p53 Protein Expression in Pancreatic Adenocarcinoma

Kim SS, Kim MC, Hong SH

  • KMID: 2209425
  • J Korean Surg Soc.
  • 2001 Jul;61(1):86-94.
PURPOSE: This study was designed to examine the microvessel count and p53 protein expression level in pancreatic adenocarcinoma patients and to determine how they correlate with the clinicopathologic factors and...
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Immunohistochemical Evaluation of Ki - 67 , p53 , K - ras Expression in Chronic Pancreatitis and Pancreatic Adenocarcinoma

Kim IH, Lee DH, Lee JW, Choi W, Kim PS, Kim HG, Kwon KS, Cho HG, Shin YW, Kim YS, Kim YB

  • KMID: 2084984
  • Korean J Gastroenterol.
  • 2001 May;37(5):370-378.
BACKGROUND/AIMS: Hyperplasia or dysplasia of pancreatic duct epithelium has been frequently found in the pancreas of pancreatic cancer or chronic pancreatitis. We hypothesized that ductal hyperplasia and dysplasia in the...
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Biliary Tract and Pancreas: Survival and Recurrence Pattern after Curative Resection of Pancreatic Cancer

Whang YW, Jang HJ, Lee JK, Seo JH, Park YS, Lee JH, Lee SJ, Lee JP, Song SY, Chung JB, Kang JK

  • KMID: 2304591
  • Korean J Gastroenterol.
  • 2001 Oct;38(4):276-283.
BACKGROUND/AIMS: The only hope for the cure of pancreatic adenocarcinoma is curative resection. However, the rate of recurrence after curative resection is higher than 50%. The aim, of this study...
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A Case of Umbilical Metastasis as the Presenting Sign of Pancreatic Adenocarcinoma

Chang WI, Han SW, Yoon JG, Lee DH, Sung YJ, Kim BW, Kim JI, Park SH, Oh SH, Song HJ, Choi KY, Sun HS

  • KMID: 2084976
  • Korean J Gastroenterol.
  • 2001 Jan;37(1):60-63.
Metastatic cancer of the umbilicus is very rare and is called Sister Mary Joseph's nodule. The most common primary site of umbilical metastasis is an adenocarcinoma of the stomach and...
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Significance of K-ras mutation, K-ras expression and p53 expression in pancreatic cancer

Kim YC, Choi KH, Kim HG, Lee ES, Son GS

  • KMID: 2244393
  • Korean J Hepatobiliary Pancreat Surg.
  • 2000 Feb;4(1):111-121.
BACKGROUND: Though K-ras mutation and aberrant p53 have been considered the event of the oncogenesis of pancreatic adenocarcinoma, it is controversial that these have been attributed to difference of survival...
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Significance of K-ras Mutation and p53 Protein Expression in Pancreatic Adenocarcinoma

Kim YC, Choi KH

  • KMID: 2145297
  • J Korean Surg Soc.
  • 2000 Feb;58(2):271-279.
BACKGROUND: Activation of the K-ras oncogene by specific point mutations at codon 12 occurs at a remarkably high frequency in pancreatic adenocarcinomas. Also, inactivation of the p53 suppressor gene function...
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