- TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells
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Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS
- KMID: 1103688
- Exp Mol Med.
- 2007 Feb;39(1):121-127.
TNF-alpha plays a variety of biological functions such as apoptosis, inflammation and immunity. PTEN also has various cellular function including cell growth, proliferation, migration and differentiation. Thus, possible relationships between... -
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- PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells
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Hwang PH, Kim SY, Lee JC, Kim SJ, Yi HK, Lee DY
- KMID: 1089448
- Exp Mol Med.
- 2005 Oct;37(5):391-398.
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. Its major function is likely to be the phosphatase activity that regulates the... -
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