- Determination of Repeat Numbers of (CA)n in Mitochondrial D-loop using Polymerase Chain Reaction-single Strand Conformational Polymorphism (PCR-SSCP)
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Kim JY, Kim DK
- KMID: 2429144
- Korean J Phys Anthropol.
- 2018 Sep;31(3):77-82.
- doi: 10.11637/kjpa.2018.31.3.77
Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis is a kind of sensitive mutation detection method that has been usually used in field of medical genetics. A single DNA strand... -
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- p53 Mutation and p53 Protein Expression in Gastric Cancer Tissues
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Ku KB, Park SH, Chung HY, Yu W, Lee MH
- KMID: 2211067
- J Korean Surg Soc.
- 2007 Apr;72(4):283-289.
PURPOSE: Variable changes occur in the progression from normal gastric epithelium to cancer, including many tumor, tumor suppressor and DNA repair genes, as well as growth factor and its receptors.... -
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- Comparision of PCR-RFLP, PCR-SSCP, Amplication Refractory Mutation System (ARMS) in Leu72Met Polymorphism of Ghrelin Gene
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Kang JS, Kim SR, Kim SY, Joo CU, Cho SC, Hwang PH
- KMID: 2279065
- Korean J Pediatr.
- 2005 Oct;48(10):1068-1075.
PURPOSE: The role of ghrelin, which promotes the secretion of growth hormone, was not well known until now. Recently it was found that the mutation of ghrelin gene is related... -
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- The Property of p53 Gene in Cell Lines of Squamous Cell Carcinoma
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Jin Y, Moon YS, Jeong HS, Jang SI, Choi IJ
- KMID: 2224509
- Korean J Anat.
- 2004 Jun;37(3):293-299.
The mutation of p53 tumor suppressor gene is the most common genetic variation of primary malignant tumors. The occurrence, progression and reaction for medical management of cancers can be different... -
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- Study on the expression and detection of the p53 mutation in Korean colon cancer cell lines
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Jung JY, Oh SJ
- KMID: 2054226
- Immune Netw.
- 2001 Aug;1(2):151-161.
- doi: 10.4110/in.2001.1.2.151
BACKGROUND: Inactivation in p53 tumor suppressor gene through a point mutation and deletion is one of the most frequent genetic changes found in human cancer, with 50% of an incidence.... -
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- Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at the early stage of colorectal carcinogenesis
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Cho JH, Roe IH, Lim CY, Park DK, Kim WH, Kim YI
- KMID: 2157547
- J Korean Med Sci.
- 2000 Dec;15(6):667-674.
- doi: 10.3346/jkms.2000.15.6.667
We analyzed the expression of p21, bcl2, and p53 in normal and different pathologic mucosa of the human colorectum using immunohistochemistry and cold polymerase chain reaction-single strand conformation polymorphism. The topography... -
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- Molecular variants of the FSH receptor exon 10 (Thr307Ala; A919G) in premature ovarian failure (POF) women by PCR-SSCP
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Kim NK, Lee SH, Nam YS, Sohn TJ, Park SH, Park C, Ko JJ, Cha KY
- KMID: 2262030
- Korean J Obstet Gynecol.
- 2000 Jul;43(7):1144-1146.
OBJECTIVE: This study was performed to determine whether the FSH receptor mutation is present in infertile Korean patients with 46,XX premature ovarian failure (POF) women. METHODS: The variant of FSH receptor... -
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- Two Case Reports of Spinal Muscular Atrophy(SMA) Confirmed by Molecular Genetic Studies
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Woo HY, Choi KM, Lee MH, Kim BJ, Kim HS, Kim JW
- KMID: 2225956
- Korean J Clin Pathol.
- 2000 Jun;20(3):342-348.
We present two cases of the patients with spinal muscular atrophy(SMA) confirmed by molecular genetic studies. The first one is 1-year-old female child with SMA type II(Dubowitz disease) who visited... -
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- Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer
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Shin JY, Kim HS, Lee KS, Kim JB, Park JB, Won MH, Chae SW, Choi YH, Choi KC, Park YE, Lee JY
- KMID: 1109306
- Exp Mol Med.
- 2000 Jun;32(2):79-83.
Cyclin-dependent kinase inhibitors (CDKI) are negative regulators of cell cycle progression by binding the cyclin-CDK complex and inhibiting the CDK activity. Genetic alteration in the CDKI genes has been implicated... -
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- Identification of Mycobacterium avium complex ( MAC ) clinical Strains to a Species Level by Sequencing and PCR - SSCP Analysis of rpoB DNA
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Kim BJ, Lee SH, Lee KH, Park CK, Choi MS, Kim IS, Choi SB, Hwang ES, Cha CY, Kim SJ, Bai GH, Kook YH
- KMID: 1543612
- J Korean Soc Microbiol.
- 1999 Oct;34(5):491-500.
A recent study showed that comparative sequence analysis of rpoB DNAs could reveal natural relationships in genus Mycobacterium [J Clin Microbiol. 37 (6). 1999]. rpoB DNAs showed interspecies variation and... -
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- Sequencing of p53 Gene Mutations in Primary Breast Cancer Tissues
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Bae JW, Koo BH, Whang CW, Park SH, Kim IS
- KMID: 2329160
- J Korean Cancer Assoc.
- 1999 Aug;31(4):663-669.
PURPOSE: The etiology of breast cancer involves very complex factors such as genetic, hormonal, and dietary. The peak age of Korean breast cancer is much earlier, about ten years, than... -
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- A Case of Glucose-6-phosphate dehydrogenase Riley Causing Hemolytic Anemia
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Park SW, Lee HJ, Lee W, Whang KT
- KMID: 2083383
- Korean J Hematol.
- 1999 May;34(2):334-337.
A glucose-6-phoshate dehydrogenase variant called G6PD Riley was detected in an Korean boy with nonspherocytic hemolytic anemia. Using polymerase chain reaction based single-strand conformation polymorphism (PCR-SSCP) followed by DNA sequence... -
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- A Comparative Study of the Detection of the p53 Abnormality in Breast Cancer by Using PCR-SSCP and Antibody Staining
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Bae JW, Lee ES, Cho MY, Koo BH, Whang CW, Kim IS, Park SH, Lee MJ
- KMID: 2145324
- J Korean Surg Soc.
- 1999 Feb;56(2):167-173.
BACKGROUND: Mutations eliminating or altering the p53 protein function are the single most common genetic alteration in nearly all types of human cancers. The project of the p53 gene is... -
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- Usefulness of PCR-SSCP for tracing the pathogenesis of human papillomavirus-associated malignancy
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Kim JW, Song YS, Park NH, Kang SB, Lee HP
- KMID: 2244991
- Korean J Gynecol Oncol Colposc.
- 1998 Dec;9(4):445-452.
PURPOSE: To set up more simplified detection method for human papillomavirus (HPV) sequence polymorphism which could be used for the study of HPV-related pathogenesis, route of infection, and many... -
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- p53 Mutation in Gastric Carcinoma Detected by PCR - SSCP and Direct - Sequencing
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Lee SS, Kim SP, Sohn EJ, Hwang MS, Sohn SS
- KMID: 2175300
- J Korean Cancer Assoc.
- 1998 Dec;30(6):1069-1077.
PURPOSE: p53 gene mutations, one of the most common alterations found in human tumors, has also been detected in gastric carcinoma, and shown to have a crucial and early role... -
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- A Study of the p53 Tumor Suppressor Gene Mutations in Hepatocellular Carcinomas in Korean Patients
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Jeong JH, Lee KS, Cho YH
- KMID: 2095427
- J Korean Surg Soc.
- 1998 Nov;55(5):726-736.
BACKGROUND: Hepatocellular carcinoma is the second most common cause of death among cancers in Korea. Epidemiological studies have revealed the carrier state of the hepatitis B virus and the dietary... -
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- Mutation of The p53 Gene in Acute Myelogenous Leukemia
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Jung CW, Lee SJ, Kim WS, Ahn MJ, Chung TJ, Kim IS, Choi LY, Kim SY, Yoon HJ, Cho KS, Kim BK, Lee YY
- KMID: 1849135
- Korean J Hematol.
- 1998 Oct;33(3):303-310.
BACKGROUND: A p53 gene is one of the member of tumor suppressor genes involved in the control of cell cycle. The alteration of the p53 gene induces uncontrolled cellular proliferation... -
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- The Study of CDKN2/p16INK4A Mutation in Human Breast Cancer
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Song TJ, Lee ES, Kwon JA, Kim CS, Bae JW, Koo BH
- KMID: 2005574
- J Korean Surg Soc.
- 1998 Aug;55(2):167-175.
The p16 is a cyclin-dependent kinase inhibitor(CDKI) that inhibits cell cycle progression. In recent studies, homozygous deletions of p16 gene have been noted in some cancer cell lines, which implies... -
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- Heterogeneous HBV mutants coexist in Korean hepatitis B patients
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Keum WK, Kim JY, Kim JY, Chi SG, Hong JW, Kim SS, Ha JH, Kang IS
- KMID: 754997
- Exp Mol Med.
- 1998 Jun;30(2):115-122.
Although many hepatitis B virus (HBV) mutants have been found in all open reading frames since the precore defective mutant was initially reported, systematic investigations of diverse HBV mutant populations in hepatitis... -
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- Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
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Kim JR, Kim SY, Kim MJ, Kim JH
- KMID: 754996
- Exp Mol Med.
- 1998 Jun;30(2):109-114.
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers.... -
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