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A Novel Approach to Improving the Reliability of Manual Semen Analysis: A Paradigm Shift in the Workup of Infertile Men

Douglas C, Parekh N, Kahn LG, Henkel R, Agarwal A

Conventional semen analysis (SA) is an essential component of the male infertility workup, but requires laboratories to rigorously train and monitor technicians as well as regularly perform quality assurance assessments....
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Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein

Choi S, Joo HK, Jeon BH

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 functions in...
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Studies on In Vivo Function of Peroxiredoxins in Knockout Mice

Yu DY

Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions,...
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Autophagy in Redox Signalling

Choi TG, Kim SS

Autophagy is a major catabolic process that is involved in cellular degradation of unnecessary or dysfunctional cellular components via the lysosomal machinery. Autophagy is involved in a variety of biological...
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Dual effect of oxidative stress on NF-kappaB activation in HeLa cells

Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM

  • KMID: 755204
  • Exp Mol Med.
  • 2002 Nov;34(5):332-339.
Reactive oxygen species (ROS) has been implicated as an inducer of NF-kappaB activity in numbers of cell types where exposure of cells to ROS such as H2O2 leads to NF-kappaB...
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