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Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation

Choi MS, Ze EY, Park JY, Shin TS, Kim JG

Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the...
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Outer membrane proteins of Salmonella typhimurium as an adjuvant in rabies vaccine

Negm II, Ragab YM, Mohamed AF

Purpose The objective of the present study was to evaluate the immune-enhancing potential of Salmonella typhimurium outer membrane protein (OMP) and alum as adjuvants towards inactivated Vero cells rabies vaccine (FRV/K2). Materials...
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Immunogenicity of antigens from outer membrane vesicles of Neisseria meningitidis associated with bilayer fragment of dioctadecyldimethylammonium in Swiss adult mice

Rinaldi FM, Gaspar EB, Brito LT, Gaspari ED

Purpose In the present study, meningococcal serogroup B outer membrane vesicles (OMVs) were associated with bilayer fragments of a cationic lipid, dioctadecyldimethylammonium (DDA-BF), used as adjuvant, in an antigenic preparation tested...
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Proteins in Outer Membrane Vesicles Produced by Burkholderia cepacia are Responsible for Pro-inflammatory Responses in Epithelial Cells

Kim SY, Kim SI, Yun SH, Shin M, Lee YC, Lee JC

Gram-negative bacterial pathogens produce outer membrane vesicles (OMVs) and this secreted cargo plays a role in host-pathogen interactions. OMVs isolated from Burkholderia cepacia induce the cytotoxicity and pro-inflammatory responses both...
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Reverse vaccinology approach for the identification and characterization of outer membrane proteins of Shigella flexneri as potential cellular- and antibody-dependent vaccine candidates

Leow CY, Kazi A, Hisyam Ismail CMK, Chuah C, Lim BH, Leow CH, Banga Singh KK

PURPOSE: In the developing world, bacillary dysentery is one of the most common communicable diarrheal infections. There are approximately 169 million cases of shigellosis reported worldwide. The disease is transmitted...
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Comparative proteomic analysis of outer membrane protein 43 (omp43)-deficient Bartonella henselae

Kang JG, Lee HW, Ko S, Chae JS

Outer membrane proteins (OMPs) of Gram-negative bacteria constitute the first line of defense protecting cells against environmental stresses including chemical, biophysical, and biological attacks. Although the 43-kDa OMP (OMP43) is...
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Surface interactions between two of the main periodontal pathogens: Porphyromonas gingivalis and Tannerella forsythia

Zhu W, Lee SW

PURPOSE: Porphyromonas gingivalis and Tannerella forsythia have been implicated as the major etiologic agents of periodontal disease. These two bacteria are frequently isolated together from the periodontal lesion, and it...
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Identification of Outer Membrane Vesicles Derived from Orientia tsutsugamushi

Lee SM, Kwon HY, Im JH, Baek JH, Kang JS, Lee JS

Orientia tsutsugamushi, a causative pathogen of Scrub typhus, is a gram-negative intracellular bacterium. Outer membrane vesicles (OMVs) are produced from the membrane of bacteria and play many roles related to...
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Roles of Outer Membrane Vesicles (OMVs) in Bacterial Virulence

Lim S, Yoon H

Outer membrane vesicles (OMVs) are ubiquitous membranous structures in all Gram-negative bacteria, including pathogens and non-pathogens. Gram-positive bacteria also release membrane-derived vesicles (MV). Originating from the cell envelope, OMVs are...
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Preparation and Evaluation of a New Lipopolysaccharide-based Conjugate as a Vaccine Candidate for Brucellosis

Siadat SD, Vaziri F, Eftekhary M, Karbasian M, Moshiri A, Aghasadeghi MR, Ardestani MS, Alitappeh MA, Arsang A, Fateh A, Peerayeh SN, Bahrmand AR

Objectives Development of an efficacious vaccine against brucellosis has been a challenge for scientists for many years. At present, there is no licensed vaccine against human brucellosis. To overcome this problem,...
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Identification of Helicobacter pylori Strain 51 Major Outer Membrane Proteins by Quadrupole Time of Flight Mass Spectrometry

Kim KM, Lee SG, Cho YA, Song YG, Song JY, Kang HL, Lee WK, Cho MJ, Rhee KH, Baik SC

As part of an initial inquiry into the function of the outer membrane proteins (OMPs) of Helicobacter pylori Korean strain 51, we have conducted an extensive proteome analysis via quadrupole...
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Mechanisms of Acquiring Carbapenem-resistance in Acinetobacter Species

Jeong SH

A rapid dissemination of carbapenem-resistant Acinetobacter spp. represents a significant clinical threat. Production of OXA carbapenemases and metallo-beta- lactamases (MBLs) is the most important mechanism in acquiring carbapenem resistance in...
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Proteomic analysis of Helicobacter pylori J99 Outer Membrane Protein by Tandem Mass Spectrometry

Kim KM, Lee SG, Joo JS, Kwon YC, Bea DW, Song JY, Kang HL, Lee WK, Cho MJ, Rhee KH, Youn HS, Baik SC

The protein identity of sarcosine-insoluble outer membrane proteins (OMPs) of Helicobacter pylori J99 was determined with the basic study of understanding the function of proteins. A sarcosine-insoluble OMPs was resolved...
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The Attachment of Detergent-Extracted Outer Membrane Proteins of Orientia tsutsugamushi to the Host Cell Surface

Kim MK, Kim MJ, Lim BU, Kang JS

  • KMID: 1579122
  • J Bacteriol Virol.
  • 2004 Dec;34(4):283-289.
Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular parasite. The mechanisms by which O. tsutsugamushi invade host cells are unknown. Given the importance of surface-exposed proteins...
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Effects of Chlorhexidine Digluconate on Rotational Rate of n- (9-Anthroyloxy) stearic Acid in Porphyromonas ginginvalis Outer Membranes

Jang HO, Cha SK, Lee C, Choi MG, Huh SR, Shin SH, Chung IK, Yun I

  • KMID: 2071586
  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):125-130.
The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n- (9-anthroyloxy) stearic acid was used...
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Isolation and Detection of Vibrio vulnificus from the Southern Sea of Korea for the Prevention of V. vulnificus Infection (The Characteristics of Vibrio vulnificus Isolates from the Southern Sea of Korea)

Ju JW, Kim KS, Hoe MS, Jung CR

  • KMID: 2146926
  • J Korean Soc Microbiol.
  • 1998 Aug;33(4):361-372.
Vibrio vulnificus, which causes serious septicemia, has been isolated from the Southern Sea of Korea. Five strains were identified by Farmer's biochemical test and API 20E kit. V. vulnificus ATCC...
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Immunogenecity of Outer Membrane Proteins of vibro vulnificus

Kim HS, Park WJ, Lee NG, Ju JW, Hoe MS, Jung CR

  • KMID: 2146925
  • J Korean Soc Microbiol.
  • 1998 Aug;33(4):353-360.
To provide basic information on the pathogengenesis of Vibrio vulnificus infection and for the manufacture of effective vaccine, outer membrane proteins (OMPs) were extracted from V. vulnificus ATCC 27562 strain...
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Safety and Immunogenicity of a Pseudomonas aeruginosa Outer Membrane Protein Vaccine(CFC-101) : a Phase I/IIa Clinical Trial

Jang IJ, Kim IS, Yu KS, Yim DS, Kim HK, Shin SG, Chang WH, Park WJ, Lee NG, Jung SB, Ahn DH, Cho YJ, Ahn BY, Lee Y, Kim YG, Nam SW, Kim HS

  • KMID: 2248574
  • Korean J Infect Dis.
  • 1998 Jun;30(3):267-277.
BACKGROUND: We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine, CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and...
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Histopathologic Study of the Outer Membrane of Chronic Subdural Hematoma Related to Membrane Permeability

Park YK, Lee KC, Lee HK

  • KMID: 1955163
  • J Korean Neurosurg Soc.
  • 1995 Apr;24(4):444-449.
Permeability of membrane of chronic SDH is a unique characteristic. And various types of attenuation of chronic subdural hematoma(SDH) appearing on computerized tomography(CT) scans are related to the changes occurring...
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The Difference of Membrane Permeability of Chronic Subdural Hematoma Related to Attenuation on computerized Tomography

Park YK, Chung HS, Lee KC, Chu JW, Lee HK

  • KMID: 1673181
  • J Korean Neurosurg Soc.
  • 1994 Mar;23(3):269-275.
No abstract available.
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