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Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1

Song MK, Lee ZH, Kim HH

Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone...
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Serum amyloid A inhibits RANKL-induced osteoclast formation

Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS

When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator...
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High extracellular Ca2+ alone stimulates osteoclast formation but inhibits in the presence of other osteoclastogenic factors

Shin MM, Kim YH, Kim SN, Kim GS, Baek JH

  • KMID: 1094697
  • Exp Mol Med.
  • 2003 Jun;35(3):167-174.
High ambient Ca2+ at bone resorption sites have been implicated to play an important role in the regulation of bone remodeling. The present study was performed to clarify the mode...
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