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Intranasal Vaccination with OuterMembrane Protein of Orientia tsutsugamushi induces Protective Immunity Against Scrub Typhus

Park SM, Gu MJ, Ju YJ, Cheon IS, Hwang KJ, Gill B, Shim BS, Jeong HJ, Son YM, Choi S, Jeung W, Han SH, Chu H, Yun CH

Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub...
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Erythematous Patch in Tsutsugamushi Disease – An Atypical Form of Eschar

Chung MH, Kang JS

Tsutsugamushi disease is caused by the bacterium, Orientia tsutsugamushi and transmitted by chigger mites. In addition to the typical dark eschar, various forms of the eschar, including papules and vesicles,...
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Acute Cholangitis Caused by Boryong Strain of Orientia tsutsugamushi

Lee KH, Heo ST, Jeong SU, Kim My, Jeong WS, Hyun CL, Kim YK, Yoo JR

Scrub typhus present with a variety clinical manifestations caused by Orientia tsutsugamushi, it is sometimes accompanied by severe complications. The clinical course of this complication is not well clear. Herein,...
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History of Tsutsugamushi Disease in Korea

Chung MH, Kang JS

Tsutsugamushi disease or scrub typhus in Korea was first officially reported in foreign soldiers in 1951 and in indigenous persons in 1986. However, the history is further prolonged. The book...
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Survey of Rickettsia spp. and Orientia tsutsugamushi Pathogens Found in Animal Vectors (Ticks, Fleas, Chiggers) in Bangkaew District, Phatthalung Province, Thailand

Sanprick A, Yooyen T, Rodkvamtook W

Rickettsial infections (Rickettsioses) are the causes of acute fever found in Thailand. It is classified as acute febrile illnesses transmitted by bloodsucking arthropod vectors (tick, flea, and chigger). This research...
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Annual Fluctuation in Chigger Mite Populations and Orientia Tsutsugamushi Infections in Scrub Typhus Endemic Regions of South Korea

Kim SY, Gill B, Song BG, Chu H, Park WI, Lee HI, Shin EH, Cho SH, Roh JY

OBJECTIVES: Chigger mites are vectors for scrub typhus. This study evaluated the annual fluctuations in chigger mite populations and Orientia tsutsugamushi infections in South Korea. METHODS: During 2006 and 2007, chigger...
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The Eschar Size and Early Inoculation Lesion of Tsutsugamushi Disease on Jeju Island, Korea

Kim YH, Hyun W, Kim DP, Chung MH, Im JH, Baek JH, Lee JS, Kang JS

BACKGROUND: Tsutsugamushi disease, or scrub typhus, is an acute febrile illness caused by Orientia tsutsugamushi, which is followed by chronic latent infection. People who reside in areas endemic of tsutsugamushi...
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A Case of Scrub Typhus complicated with a Splenic Infarction

Durey A, Kwon HY, Park YK, Baek J, Han SB, Kang JS, Lee JS

We present a patient with scrub typhus complicated with a splenic infarction. A 40-year-old man visited the emergency medical center complaining of fever for the previous week. He had no...
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Clinical Evaluation of Rapid Diagnostic Test Kit for Scrub Typhus with Improved Performance

Kim YJ, Park S, Premaratna R, Selvaraj S, Park SJ, Kim S, Kim D, Kim MS, Shin DH, Choi KC, Kwon SH, Seo W, Lee NT, Kim SH, Kang HK, Kim YW

Diagnosis of scrub typhus is challenging due to its more than twenty serotypes and the similar clinical symptoms with other acute febrile illnesses including leptospirosis, murine typhus and hemorrhagic fever...
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In Vitro Activity of Tigecycline Against Orientia tsutsugamushi

Lee SM, Kwon HY, Im JH, Baek JH, Hwang SS, Kang JS, Chung MH, Lee JS

Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant...
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Seroepidemiological Survey of Zoonotic Diseases in Small Mammals with PCR Detection of Orientia tsutsugamushi in Chiggers, Gwangju, Korea

Park JW, Chung JK, Kim SH, Cho SJ, Ha YD, Jung SH, Park HJ, Song HJ, Lee JY, Kim DM, Pyus J, Ha DR, Kim ES, Lee JI

Serosurveillance for zoonotic diseases in small mammals and detection of chiggers, the vector of Orientia tsutsugamushi, were conducted from September 2014 to August 2015 in Gwangju Metropolitan Area. Apodemus agrarius...
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Leukocytoclastic Vasculitis Associated with Orientia tsutsugamushi Infection: A Report of Two Cases

Park HK, Choi HS, Kim YG, Yu HJ, Kim JS

  • KMID: 2368907
  • Korean J Dermatol.
  • 2016 Dec;54(10):839-841.
No abstract available.
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Isolation and Genetic Characterization of Orientia tsutsugamushi from Scrub Typhus Patients in Gyeongsangnam-do, Korea

Ha JH, Lee DH, Park JS, Cho OH, Kim DH, Ha NY, Cho NH, Hwang KJ, Cho YG, Lee HS, Lee WK, Lee YC, Cho MJ, Lee WK, Shin MK

Orientia tsutsugamushi (O. tsutsugamushi), which is endemic to an Asia-Pacific region, has increased its incidence and caused annually around 10 thousand patients infected with scrub typhus in Korea in the...
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Identification of Outer Membrane Vesicles Derived from Orientia tsutsugamushi

Lee SM, Kwon HY, Im JH, Baek JH, Kang JS, Lee JS

Orientia tsutsugamushi, a causative pathogen of Scrub typhus, is a gram-negative intracellular bacterium. Outer membrane vesicles (OMVs) are produced from the membrane of bacteria and play many roles related to...
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In vitro Antagonism between Cefotaxime and Anti-Rickettsial Antibiotics against Orientia tsutsugamushi

Lee OH, Baek JH, Lee JS, Chung MH, Lee SM, Kang JS

We have investigated the in vitro antimicrobial effects of antibiotic combinations against Orientia tsutsugamushi, the causative agent of scrub typhus. ECV304 cells were infected with the Boryong strain of O....
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In vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi

Son D, Chung MH

BACKGROUND: To investigate whether chloroquine enhances the effect of antibiotics against Orientia tsutsugamushi, the causative organism of scrub typhus, we compared the effect of antibiotics in combination with chloroquine with...
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A Review of the Electrocardiography Changes and Clinical Manifestations of Scrub Typhus in a Single Center

Kim JM, Hyun M, Kim HA, Kim MK, Kim JY, Kwon KY, Ryu SY

BACKGROUND/AIMS: Most scrub typhus patients have normal electrocardiography (ECG) findings. Recently, however, several cases with ECG changes were reported. However, few studies have examined the ECG changes in scrub typhus. METHODS:...
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A Review of Electrocardiography Changes and Clinical Manifestations in Scrub Typhus in a Single Center

Hong SP, Kim DM

The mechanism of electrocardiography (ECG) changes in patients with scrub typhus is still not clear. Orientia tsutsugamushi causes vasculitis in scrub typhus patients, which result in non-specific damage to the...
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Diagnosis of scrub typhus: introduction of the immunochromatographic test in Korea

Lee KD, Moon C, Oh WS, Sohn KM, Kim BN

No abstract available.
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In Vitro Bacteriostatic Effects of Rifampin on Orientia tsutsugamushi

Im JH, Baek JH, Lee JS, Chung MH, Lee SM, Kang JS

We performed an in vitro cell culture experiment to ascertain whether rifampin exhibits bactericidal effects against Orientia tsutsugamushi, the causative agent of scrub typhus. ECV304 cells were infected with the...
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