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The effects of wild type p53 tumor suppressor gene expression on the normal human cervical epithelial cells or human epidermal keratinocytes transformed with human papillomavirus type 16 DNA

Kim KH, Park TK, Yoon DJ, Kim YS

The inactivation of p53 and p105RB by viral proteins or by mutations plays a key role in the oncogenesis of cervical carcinoma. The E6 and E7 proteins of HPV type...
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DNA vaccines for cervical cancer: from bench to bedside

Hung CF, Monie A, Alvarez RD, Wu TC

  • KMID: 1091062
  • Exp Mol Med.
  • 2007 Dec;39(6):679-689.
More than 99% of cervical cancers have been associated with human papillomaviruses (HPVs), particularly HPV type 16. The clear association between HPV infection and cervical cancer indicates that HPV serves...
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Human Papillomavirus 16/18 Expression of Endocervical Glandular Lesions: Relationship with p53 and MIB-1 Expressions

Yoon HK, Kim YJ, Kang MS

The pathogenesis of endocervical glandular lesions are not clearly understood. The aims of this study are to evaluate the etiologic role of human papillomavirus (HPV) 16/18 and the relationship of...
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Characterization of Immortalized Human Corneal Endothelial Cell Line using HPV 16 E6/E7 on Lyophilized Human Amniotic Membrane

Kim HJ, Ryu YH, Ahn JI, Park JK, Kim JC

PURPOSE: To establish the immortalized human corneal endothelial cell line (IHCEn) by transducing human papilloma virus (HPV) 16 E6/E7 oncogenes, and to identify their characteristics when cultivated on a...
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Immunocytochemical detection of HPV16 E7 in cervical smear

Jeon JH, Shin DM, Cho SY, Song KY, Park NH, Kang HS, Kim YD, Kim IG

  • KMID: 1090965
  • Exp Mol Med.
  • 2007 Oct;39(5):621-628.
Cervical cancer is characterized by a long period of preclinical dysplasia or carcinoma in situ progressing into invasive cancer. Although Papanicolaou (Pap) smear test has contributed significantly to the early...
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