- Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin
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Kim YS, Seol CH, Jung JW, Oh SJ, Hwang KE, Kim HJ, Jeong ET, Kim HR
- KMID: 2380394
- Cancer Res Treat.
- 2015 Jan;47(1):90-100.
- doi: 10.4143/crt.2013.194
PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) and statins are potential chemopreventive or chemotherapeutic agents. The mechanism underlying the deregulation of survivin by NSAIDs and statins in human non-small cell lung cancer... -
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- Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
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Tran P, Nguyen C, Klempner S
- KMID: 2362506
- Int Neurourol J.
- 2016 Nov;20(Suppl 2):S131-S140.
- doi: 10.5213/inj.1632740.370
Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies. Therapeutic targeting of PI3K pathway components has improved outcomes in chronic lymphocytic leukemia, kidney cancer,... -
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- Genistein activates endothelial nitric oxide synthase in broiler pulmonary arterial endothelial cells by an Akt-dependent mechanism
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Yang Y, Nie W, Yuan J, Zhang B, Wang Z, Wu Z, Guo Y
- KMID: 994400
- Exp Mol Med.
- 2010 Nov;42(11):768-776.
- doi: 10.3858/emm.2010.42.11.078
Deregulation of endothelial nitric oxide synthase (eNOS) plays an important role in the development of multiple cardiovascular diseases. Our recent study demonstrated that genistein supplementation attenuates pulmonary arterial hypertension in... -
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- Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
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Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH
- KMID: 964666
- Exp Mol Med.
- 2010 Oct;42(10):712-720.
- doi: 10.3858/emm.2010.42.10.070
Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum... -
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- Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling
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Cucuzza LS, Motta M, Miretti S, Accornero , Baratta M
- KMID: 1072945
- Exp Mol Med.
- 2008 Dec;40(6):647-657.
- doi: 10.3858/emm.2008.40.6.647
Curcumin (from the rhizome of Curcuma longa) is well documented for its medicinal properties in Indian and Chinese systems of medicine where it is widely used for the treatment of... -
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