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Reversal of Olfactory Disturbance in Allergic Rhinitis Related to OMP Suppression by Intranasal Budesonide Treatment

Jung AY, Kim YH

PURPOSE: We evaluated the severity of olfactory disturbance (OD) in the murine model of allergic rhinitis (AR) and local allergic rhinitis (LAR) in mice. We also investigated the therapeutic effect...
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Clinical Usefulness of Trasseptal Transsphenoidal Approach for Pituitary Tumors with Septal Cartilage Removal and Replacement via Modified Killian Incision: Review of 42 Cases

Kim SY, Yang BW, Lee YW, Lee KC

BACKGROUND AND OBJECTIVES: The conventional transseptal transsphenoidal approach can inhibit visualization of the surgical field and may change the shape of external nose. We used the transseptal transsphenoidal technique to...
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A novel CHD7 mutation in an adolescent presenting with growth and pubertal delay

Antoniou M, Bouthors T, Xu C, Phan-Hug F, Elowe-Gruau E, Stoppa-Vaucher S, van der Sloot A, Acierno J, Cassatella D, Richard C, Dwyer A, Pitteloud , Hauschild

Mutations in the CHD7 gene, encoding for the chromodomain helicase DNA-binding protein 7, are found in approximately 60% of individuals with CHARGE syndrome (coloboma, heart defects, choanal atresia, retarded growth...
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The Effects of Olfactory Training with Intranasal Corticosteroid Spray in Korean Patients with Olfactory Dysfunction

Jung YD, Kim DS, Kang BJ, Shin SH, Ye MK

BACKGROUND AND OBJECTIVES: Olfactory training is an alternative treatment based on modulation of the regeneration process of the olfactory system via repeated exposure to odors. Our study aimed to investigate...
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Altered Functional Brain Networks in Patients with Traumatic Anosmia: Resting-State Functional MRI Based on Graph Theoretical Analysis

Park M, Chung J, Kim JK, Jeong Y, Moon WJ

OBJECTIVE: Traumatic anosmia is a common disorder following head injury; however, little is known regarding its neural basis and influence on the functional networks. Therefore, we aimed to investigate the...
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Do Eosinophilic Polyps Act as a Reliable Predictor of Olfactory Dysfunction and Postoperative Recovery in Chronic Rhinosinusitis?

Im D, Yang YS, Choi HR, Han K, Hong SC, Cho JH, Kim JK

BACKGROUND AND OBJECTIVES: The purpose of this study was 1) to assess differences in categories of olfactory dysfunction according to the pathological classification of chronic rhinosinusitis with nasal polyp (CRSwNP)...
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Clinical Feasibility of Scent Survey for Screening Test for Olfactory Function

Yang Y, Choi HR, Cho JH, Hong SC, Kim JK

BACKGROUND AND OBJECTIVES: The scent survey for screening (SSS) test is a subjective olfactory questionnaire devised for this study. We demonstrated the correlation of the SSS test with other olfactory...
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The Predictive Factors of Olfactory Changes after Endoscopic Sinus Surgery

Ye MK

Olfactory dysfunction is one of the most common complaints of patients with chronic rhinosinusitis. Patients who suffer from olfactory dysfunction report a negative effect on their overall quality of life....
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The Effect of Olfactory Training Using Korean Version Odorants: A Preliminary Study

Kim BG, Kim BY, Shin JH, Kim SW, Kim SW

BACKGROUND AND OBJECTIVES: Several studies have reported the benefits of olfactory training (OT) for patients with olfactory dysfunction. However, training odorants should be customized according to the characteristics of individual...
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Work-related olfactory disorder: a case series and review

Park SW, Kang YJ, Eom H, Cho HJ, Ahn J, Lee SG

BACKGROUND: The olfactory bulb is anatomically exposed and thus can be directly damaged by external stimulation. This can occur as an occupational injury owing to contact with organic solvents or...
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Olfaction and Alzheimer Disease

Lee JE

Olfactory deficits have been reported to be associated with neurological disorders such as Alzheimer's disease (AD), idiopathic Parkinson's disease and several other types of dementia. There has been increasing interest...
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The Effect of Sleep Disordered Breathing on Olfactory Functions: Analysis by Apnea-Hypopnea Index

Shin DH, Ahn SH, Yang Y, Choi S, Cho JH, Hong SC, Kim JK

OBJECTIVES: One hypothesis of obstructive sleep apnea syndrome (OSAS) is that long-standing snoring vibrations and hypoxia of the nerves cause a local neuropathy in the upper airway during sleep. The...
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Subfrontal Schwannoma Extended Broadly to Nasal Cavity Treated by Gamma Knife Radiosurgery Following Surgical Excision: A Case Report

Kim SH, Lee JH, Sung SK, Choi CH

Subfrontal schwannomas are rarely reported. They are usually found only in the subfrontal area, but some extend to the nasal cavity. In these cases, prevention of postoperative cerebrospinal fluid (CSF)...
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Complex Anterior Skullbase Fracture Caused by a Bottle Cap: A Case Report and Review of the Literature

Cho J, Kim JH, Hong SD

We report a case of foreign body presence in the ethmoid sinus cavity with anterior skull base fracture and visual loss. A 42-year-old male had an uncertain history of trauma...
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Feasibility and Efficacy of Olfactory Protection Using Gelfoam and Fibrin Glue during Anterior Communicating Artery Aneurysm Surgery

Cho H, Jo KI, Yeon JY, Hong SC, Kim JS

OBJECTIVE: Patients treated with surgical clipping for anterior communicating artery (A-com) aneurysm often complain of anosmia, which can markedly impede their quality of life. We introduce a simple and useful...
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Clinical, endocrinological, and molecular characterization of Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: a single center experience

Shin SJ, Sul Y, Kim JH, Cho JH, Kim GH, Kim JH, Choi JH, Yoo HW

PURPOSE: Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is classified as Kallmann syndrome (KS) with anosmia and normosmic idiopathic hypogonadotropic hypogonadism (nIHH). This study was undertaken to investigate the clinical, endocrinological,...
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Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future

Kim SH

The proper development and coordination of the hypothalamic-pituitary-gonadal (HPG) axis are essential for normal reproductive competence. The key factor that regulates the function of the HPG axis is gonadotrophin-releasing hormone...
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The Current Status of Evaluation Technologies for the Function of Human Olfaction

Kim WS, Jang DP, Kim IY

The sense of smell is one of the essential tools for all living things to survive. With recent increase in diseases associated with olfactory dysfunction, the evaluation of olfactory function...
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Clinical Diagnosis and Treatment of Olfactory Dysfunction

Cho SH

Olfactory dysfunction is a relatively common disorder that is often under-recognized by both patients and clinicians. It occurs more frequently in older ages and men, and decreases patients' quality of...
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Application of Mesenchymal Stem Cells in Rhinologic Fields

Cho KS

Mesenchymal stem cells (MSCs) are adult stem cells which are present in a variety of adult tissues and reside in essentially all post-natal organs and tissues. MSCs represent an important...
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