- Okadaic Acid, RK682 and Calyculin Modulate TcR - Mediated Signaling Events
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Lee SK, Lim JH, Cho KM, Kim HJ, Kim SW, Song YS
- KMID: 2082998
- Korean J Immunol.
- 1997 Sep;19(3):327-336.
The T cell antigen receptor (TcR) in combination with costimulatory signals triggered by accessory molecules present on the surface of the antigen-presenting cells (APC) regulates the activation and growth of... -
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- Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells
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Nam EJ, Lee HS, Lee YJ, Joo WS, Maeng S, Im HI, Park CW, Kim YS
- KMID: 1615193
- Korean J Physiol Pharmacol.
- 2002 Dec;6(6):281-286.
To understand the cytotoxic mechanism of MPP+, we examined the involvement of ceramide in MPP+ -induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP+, MPP+... -
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- Role of Ca2+ in the stimulation of glucose transport by insulin in adipocytes
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Chang SH, Jang YJ, Park KK, Kim GS, Ryu HJ, Park CS
- KMID: 2285230
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):357-364.
We investigated the role of Ca2+ and protein kinases/phosphatases in the stimulatory effect of insulin on glucose transport. In isolated rat adipocytes, the simple omission of CaCl2 from the incubation medium significantly reduced,... -
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- Protein Kinase C Activates ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes
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Kim N, Youm JB, Joo H, Kim H, Kim E, Han J
- KMID: 1600067
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):187-193.
Several signal transduction pathways have been implicated in ischemic preconditioning induced by the activation of ATP-sensitive K+ (KATP) channels. We examined whether protein kinase C (PKC) modulated the activity of... -
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- Rapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
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Park CE, Ko SM, Kim JM, Yoon MY, Kim JY, Kang IS, Kim SS, Ha JH
- KMID: 754991
- Exp Mol Med.
- 1998 Jun;30(2):73-79.
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, alpha and beta, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-alpha is highly expressed in lipogenic tissues whereas... -
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- Modulation of Ca2+ activated potassium channels by cGMP-dependent signal transduction mechanism in cerebral arterial smooth muscle cells of the rabbit
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Han J, Kim N, Lee K, Kim E
- KMID: 1581022
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):445-453.
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2+-activated potassium channel (KCa channel) and is involved in the activation of KCa channel... -
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- Effect of serum and hydrogen peroxide on the Ca2+/calmodulin-dependent phosphorylation of eukaryotic elongation factor 2(eEF-2) in Chinese hamster ovary cells
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Kang KR, Lee SY
- KMID: 1457530
- Exp Mol Med.
- 2001 Dec;33(4):198-204.
Eukaryotic elongation factor eEF-2 mediates regulatory steps important for the overall regulation of mRNA translation in mammalian cells and is activated by variety of cellular conditions and factors. In this... -
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- Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser¹¹â·â¹ Dephosphorylation
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Cho DH
- KMID: 2461172
- J Korean Med Sci.
- 2019 Nov;34(42):e266.
- doi: 10.3346/jkms.2019.34.e266
BACKGROUND: Apart from its blood pressure-lowering effect by blocking the renin-angiotensin-aldosterone system, telmisartan, an angiotensin II type 1 receptor blocker (ARB), exhibits various ancillary effects including cardiovascular protective effects in... -
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