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Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation

Lee KH, Park HW

In the last decade, non-vitamin K antagonist oral anticoagulants (NOACs), a new generation of OACs, were introduced to prevent thromboembolism in patients with atrial fibrillation. Although vitamin K-dependent anticoagulants have...
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Two-year Clinical Outcomes Following Everolimus-eluting Stent Use for Off-label Versus On-label Indications: From the Korean Multicenter Drug-eluting Stent Registry

Pae JY, Lee CH, Choi JY, Park HS, Kim DK, Hyun DW, Jeong YS, Lee SK, Kim YJ, Kim KB

BACKGROUND: Everolimus-eluting stent (EES) implantations have a relatively low rate of major adverse cardiac event (MACE) and target lesion revascularization (TLR) in patients with off-label use. However, the clinical outcome...
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Safety and Efficacy of Off-label and Unlicensed Medicines in Children

Lee JH, Byon HJ, Choi S, Jang YE, Kim EH, Kim JT, Kim HS

BACKGROUND: The aim of this study was to explore the use of off-label/unlicensed drugs to confirm the safety and efficacy of their prescription in children in Korea. METHODS: In this retrospective...
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Appropriate off-label drug use

Lee SM

After new drugs are introduced into an area of medical practice through the regulatory approval process, clinicians gain further experience using the drugs and amass real-world evidence regarding their efficacy....
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Gemcitabine and Docetaxel Combination for Advanced Soft Tissue Sarcoma: A Nationwide Retrospective Study

Choi Y, Yun MS, Lim SH, Lee J, Ahn JH, Kim YJ, Park KH, Park YS, Lim HY, An H, Suh DC, Kim YH

PURPOSE: This nationwide retrospective study was conducted to evaluate the efficacy and safety of combined gemcitabine and docetaxel (GD) as an off-label therapy for advanced soft tissue sarcoma, which has...
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Prescription Pattern of Antidepressants for Children and Adolescents in Korea Based on Nationwide Data

Chon MW, Lee J, Chung S, Kim Y, Kim HW

Antidepressant prescription for youths has recently been on the increase. There is a growing concern over the increasing off-label usage of antidepressants. Current data on off-label antidepressant usage vary across...
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Five-year clinical outcomes of drug-eluting stents according to on-label and off-label use

Park KH, Kim U, Lee CH, Son JW, Park JS, Shin DG, Kim YJ, Cho JH

BACKGROUND/AIMS: To compare the clinical outcomes of 'on-label' and 'off-label' drug-eluting stents (DESs) over a 5-year follow-up period. METHODS: A total of 929 patients that underwent percutaneous coronary intervention with DESs...
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Off-label or Unlicensed Drug Prescriptions in Child and Adolescent Psychiatry

Lee SI

  • KMID: 2291680
  • J Korean Acad Child Adolesc Psychiatry.
  • 2011 Jun;22(2):67-73.
The purpose of licensing system is to ensure that the medicines are examined for safety, efficacy and quality. Nevertheless, off-label or unlicensed drug usages in pediatric practice is widespread in...
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