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Safety and Effectiveness of Darunavir in Korean Patients with Human Immunodeficiency Virus 1 Infection: A Post-Marketing Observational Study

Kim H, Kim Y, Kang J

We aimed to evaluate the safety and effectiveness of darunavir (DRV) in the treatment of human immunodeficiency virus-1 (HIV-1) infection in Korea. From October 29, 2010, 225 eligible patients with...
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5-HT1A Partial Agonist Tandospirone for Behavioral and Psychological Symptoms in Oldest-old Patients with Dementia at a Special Elderly Nursing Home

Ochi S, Mori T, Iga Ji, Ueno Si

Objective: To investigate the efficacy of tandospirone, an azapirone anxiolytic similar to buspirone that is used in Japan, for behavioral and psychological symptoms of dementia (BPSD), especially in oldest-old patients. Methods:...
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The role of percutaneous neurolysis in lumbar disc herniation: systematic review and meta-analysis

Manchikanti L, Knezevic E, Knezevic NN, Sanapati MR, Kaye AD, Thota S, Hirsch JA

Background: Recalcitrant disc herniation may result in chronic lumbar radiculopathy or sciatica. Fluoroscopically directed epidural injections and other conservative modalities may provide inadequate improvement in some patients. In these cases,...
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Screening for sarcopenia and obesity by measuring thigh muscle and fat thickness by ultrasound in patients with rheumatoid arthritis

Tada M, Yamada Y, Mandai K, Hidaka N

Objectives: Sarcopenia is relatively common in rheumatoid arthritis (RA) patients. Thicknesses of the quadriceps muscle and fat are easily measured by ultrasound (US) and are known to be related to...
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Drug treatment patterns and work productivity in chronic kidney disease patients with anemia in China: cross sectional analysis of real-world data

Haalen Hv, Sloand J, Moon R, Palaka E, Milligan G, Allum A, Jackson J

Background: We explored the association of anemia severity in patients with chronic kidney disease (CKD) and anemia treatment with work productivity in China. Methods: Cross-sectional survey data from Chinese physicians and...
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A brief introduction to propensity score for anesthesiologists

De Cassai A, Andreatta G, Boscolo A, Munari M, Navalesi P

Intergroup comparability is of paramount importance in clinical research since it is impossible to draw conclusions on a treatment if populations with different characteristics are compared. While an adequate...
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Prognostic factors related with outcomes in traumatic out-of-hospital cardiac arrest patients without prehospital return of spontaneous circulation:a nationwide observational study

Jun GS, Kim JG, Choi HY, Kang GH, Kim W, Jang YS, Kim HT

Objective To evaluate the prognostic factors associated with the sustained return of spontaneous circulation (ROSC) and survival to hospital discharge in traumatic out-of-hospital cardiac arrest (TOHCA) patients without prehospital ROSC. Methods...
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Efficacy and Safety of Pitavastatin in a Real-World Setting: Observational Study Evaluating SaFety in Patient Treated with Pitavastatin in Korea (PROOF Study)

Jeong IK, Kim SR

Background: While randomized controlled trials provide useful information about drug safety and efficacy, they do not always reflect the observed results in the real world. The prospective, observational, non-comparative trial...
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Pervasive Misclassification and Misconception of Study Designs in Asian Dermatology Journals Listed in Science Citation Index-Expanded

Choi S, Yoon HS

Background: Misclassification of study designs of journals can hinder the readers from assessing the strengths and weaknesses of the study and evaluating the applicability of the study in the real-world...
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Dietary Intake of Omega-3 fatty acids and Endocrine-related Gynecological Cancer: A Meta-Analysis of Observational Studies

Hoang T, Myung SK, Pham TT

PURPOSE: Previous observational epidemiological studies have reported inconsistent findings on the association between dietary intake of omega-3 fatty acids and endocrine-related gynecological cancer such as ovarian cancer and endometrial cancer....
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The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study

Cho JH, Rhee EJ, Park SE, Kwon H, Jung JH, Han KD, Park YG, Park HS, Kim YH, Yoo SJ, Lee WY, on behalf of Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity

BACKGROUND: Waist circumference (WC) is a well-known obesity index that predicts cardiovascular disease (CVD). We studied the relationship between baseline WC and development of incident myocardial infarction (MI) and ischemic...
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Effectiveness of monthly intravenous ibandronate injections in a real-world setting: Subgroup analysis of a postmarketing observational study

Takeuchi Y, Hashimoto , Kakihata H, Nishida Y, Kumagai M, Yamagiwa C

OBJECTIVES: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis. Here, we present subgroup...
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Hand Hygiene Compliance among Visitors at a Long-term Care Hospital in Korea: A Covert Observation Study

Jung MY, Kang J

PURPOSE: This study aimed to assess hand hygiene (HH) compliance among visitors at a long-term care hospital in South Korea. METHODS: The study was conducted at a 502-bed long-term care hospital...
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The Multi-Institutional Health Screening Records Database of South Korea: Description and Evaluation of Its Characteristics

Noh Y, Jeong HE, Kim HJ, Ko H, Nah EH, Shin JY

This study sought to describe and to evaluate the characteristics of the Health Screening Records Database (HSRD) of the Korea Association of Health Promotion as a data source for epidemiologic...
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Preventive Effect of an SGLT2 Inhibitor on Cardiovascular Disease in an Observational Study: Results from a Korean Population

Ha KH, Kim DJ

The sodium-glucose cotransporter-2 inhibitor (SGLT2i) is a new anti-hyperglycemic agent that have function to concomitantly inhibit the reabsorption of glucose and sodium in the renal proximal convoluting tubule. Recent two...
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Use of Hypnotics and Risk of Cancer: A Meta-Analysis of Observational Studies

Kim DH, Kim HB, Kim YH, Kim JY

BACKGROUND: Previous observational epidemiological studies have shown inconsistent results on the relationship between hypnotics use and risk of cancer. To determine the association between hypnotics use and risk of cancer,...
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Use of hypnotics and the risk of or mortality from heart disease: a meta-analysis of observational studies

Kim YH, Kim HB, Kim DH, Kim JY, Shin HY

BACKGROUND/AIMS: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using...
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The MAKE Biomarker Discovery for Enhancing anTidepressant Treatment Effect and Response (MAKE BETTER) Study: Design and Methodology

Kang HJ, Kim JW, Kim SY, Kim SW, Shin HY, Shin MG, Kim JM

OBJECTIVE: Depression is associated with a major disease burden, and many individuals suffer from depressive symptoms due to an insufficient response to ostensibly adequate antidepressant treatment. Therefore, it is important...
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Safety and effectiveness of monthly intravenous ibandronate injections in a prospective, postmarketing, and observational study in Japanese patients with osteoporosis

Takeuchi Y, Hashimoto , Nishida Y, Yamagiwa C, Tamura T, Atsumi A

OBJECTIVES: This postmarketing, observational study evaluated the safety and effectiveness of monthly intravenous (IV) ibandronate in Japanese patients with osteoporosis. METHODS: Eligible patients received monthly IV ibandronate 1mg for 12 months....
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Real-World Treatment Patterns among Patients with Advanced Gastric Cancer in South Korea

Carter GC, Kaltenboeck A, Ivanova J, Liepa AM, San Roman , Koh M, Rajan N, Cheng R, Birnbaum H, Kim JS, Bang YJ

PURPOSE: The purpose of this study was to understand patient treatment patterns, outcomes, and healthcare resource use in cases of metastatic and/or locally recurrent, unresectable gastric cancer (MGC) in South...
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