- Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins
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Oh KS, Kim EY, Yoon M, Lee CM
- KMID: 1047090
- Exp Mol Med.
- 2007 Jun;39(3):385-394.
Leptin receptor deficiency causes morbid obesity and hyperlipidemia in mice. Since physical exercise enhances energy expenditure, it is an important part of successful weight-control regimens. We investigated the mechanism by... -
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- Association of UCP1 Genetic Polymorphisms with Blood Pressure among Korean Female Subjects
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Cha MH, Kang BK, Suh D, Kim KS, Yang Y, Yoon Y
- KMID: 1783060
- J Korean Med Sci.
- 2008 Oct;23(5):776-780.
- doi: 10.3346/jkms.2008.23.5.776
Recent studies have provided some clues with regard to the relationship existing between uncoupling protein 1 (UCP1) and blood pressure in animal experiments. In an attempt to determine the genetic... -
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- Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet
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Kim BH, Won YS, Kim EY, Yoon M, Nam KT, Oh GT, Kim DY
- KMID: 1089604
- J Vet Sci.
- 2003 Dec;4(3):239-244.
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha(PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic... -
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- Peroxisome Proliferator-Activated Receptor-Gamma Expression in the Lung Tissue of Obese Rats
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Hwang SJ, Kim JH, Shim JW, Kim DS, Jung HL, Park MS, Lee WY, Kim SY, Shim JY
- KMID: 1777023
- Yonsei Med J.
- 2011 May;52(3):495-501.
- doi: 10.3349/ymj.2011.52.3.495
PURPOSE: Obesity is a risk factor for asthma and type II diabetes. Peroxisome proliferator-activated receptor (PPAR)-gamma has been suggested to regulate inflammatory responses in diabetes and asthma. We investigated whether... -
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- Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation
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Jhun JY, Yoon BY, Park MK, Oh HJ, Byun JK, Lee SY, Min JK, Park SH, Kim HY, Cho ML
- KMID: 1397446
- Exp Mol Med.
- 2012 Jul;44(7):424-431.
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-alpha. Rheumatoid arthritis... -
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- Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes
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Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, Kim EH, Yoo HJ, Lee CH, Park IS, Lee KU, Koh EH
- KMID: 1389736
- Exp Mol Med.
- 2012 Sep;44(9):562-570.
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER stress response, resulting... -
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