- Immunohistochemical detection of Prion protein (PrP-Sc) and epidemiological study of BSE in Korea
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Koo HC, Park YH, Lee BC, Chae C, O'Rourke K, Baszler TV
- KMID: 1103502
- J Vet Sci.
- 2001 Apr;2(1):25-31.
Though the aetiology of transmissible spongiform encephalopathies (TSEs) remains uncertain, proteinase resistant prion protein (PrP-Sc), a converted form of the normal cellular prion protein (PrP-C), accumulates in the lysosome of... -
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- Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays
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Dassanayake RP, Truscott T, Zhuang D, Schneider , Madsen-Bouterse SA, Young AJ, Stanton JB, Davis WC, O'Rourke K
- KMID: 2164527
- J Vet Sci.
- 2015 Jun;16(2):179-186.
- doi: 10.4142/jvs.2015.16.2.179
Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a)... -
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