- Isolation and Structure Determination of an Imidazo-pyrimidine, 5-Chlorocavernicolin, Maleimide oximes and Nucleosides from a Marine Sponge Extract
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Kulkarni R, Kim JH, Kim YH, Oh S, Na M
- KMID: 2409595
- Nat Prod Sci.
- 2015 Mar;21(1):25-29.
- doi: 10.0000/nps.2015.21.1.25
In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation... -
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- Metabolite Profiling during Fermentation of Makgeolli by the Wild Yeast Strain Saccharomyces cerevisiae Y98-5
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Kim HR, Kim JH, Ahn BH, Bai DH
- KMID: 2408966
- Mycobiology.
- 2014 Dec;42(4):353-360.
- doi: 10.5941/MYCO.2014.42.4.353
Makgeolli is a traditional Korean alcoholic beverage. The flavor of makgeolli is primarily determined by metabolic products such as free sugars, amino acids, organic acids, and aromatic compounds, which are... -
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- In Vitro Perfusion Studies on Coronary Function of Cardiac Ischemia-Reperfusion in Spontaneously Hypertensive Rat Heart
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Kim EJ, Kang YH
- KMID: 2228957
- Korean Circ J.
- 1995 Feb;25(1):59-67.
- doi: 10.4070/kcj.1995.25.1.59
BACKGROUND: Myocardial ischemia in human hypertension and in various animal models of hypertension may be due to abnormal maximal coronary vasodilator reserve and disturbaces of coronary vasomotion. The vascular reactivity... -
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- Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity
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Kim YS, Lee IK, Seok SJ, Yun BS
- KMID: 2411406
- Mycobiology.
- 2008 Jun;36(2):110-113.
During a continuing search for antimicrobial substances from Korean native wild mushroom extracts, we found that the methanolic extract of the fruiting body of Clitocybe nebularis exhibited mild antifungal activity... -
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- Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade
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Yim HJ, Hwang SG
- KMID: 1705199
- Clin Mol Hepatol.
- 2013 Sep;19(3):195-209.
- doi: 10.3350/cmh.2013.19.3.195
Although much advancement has been achieved in the treatment of chronic hepatitis B, antiviral resistance is still a challenging issue. Previous generation antiviral agents have already developed resistance in a... -
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- Purification and Characterization of Guanine Aminohydrolase from Rat Cerebrum
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Cha HJ, Jung HW, Koh YC, Sim BS, Park JB, Kim SW
- KMID: 1953539
- J Korean Neurosurg Soc.
- 1984 Dec;13(4):611-625.
Guanine aminohydrolase(GAH;EC 3. 5. 4. 3.) was partially purified 122-fold from rat cerebrum to a specific activity of 7.22 in its per mg protein with a recovery of 7.47% by... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- Efficacy of Tenofovir-based Rescue Therapy for Patients with Drug-resistant Chronic Hepatitis B
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Choi K, Lee HM, Jun BG, Lee SH, Kim HS, Kim SG, Kim YS, Kim BS, Jeong SW, Jang JY, Kim YD, Cheon GJ
- KMID: 2373178
- Korean J Gastroenterol.
- 2015 Jan;65(1):35-42.
- doi: 10.4166/kjg.2015.65.1.35
BACKGROUND/AIMS: Tenofovir disoproxil fumarate (TDF) plays a pivotal role in the management of drug-resistant chronic hepatitis B. However, it remains unclear whether TDF-nucleoside analogue combination therapy provides better outcomes than... -
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- New Insight for HBV DNA and HBsAg Quantitation during Antiviral Therapy in Patients with Chronic Hepatitis B
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Cho YK, Song BC
- KMID: 1128352
- Korean J Gastroenterol.
- 2011 Mar;57(3):144-149.
- doi: 10.4166/kjg.2011.57.3.144
Over the past decade, advances in the antiviral therapy in patients with chronic hepatitis B have enabled the sustained suppression of hepatitis B viral replication and the prevention of progressive... -
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- Management of Antiviral-Resistant Chronic Hepatitis B Virus Infection
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Yim HJ
- KMID: 1767539
- Korean J Gastroenterol.
- 2008 Jun;51(6):346-359.
Substantial progress has been made in the treatment of chronic hepatitis B during the past decade. Nucleos(t)ide analogues are now widely used due to their convenience, less side effects, and... -
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- High efficacy of adefovir and entecavir combination therapy in patients with nucleoside-refractory hepatitis B
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Chae HB, Kim MJ, Seo EG, Choi YH, Lee HS, Han JH, Yoon SM, Park SM, Youn SJ
- KMID: 1372654
- Korean J Hepatol.
- 2012 Mar;18(1):75-83.
- doi: 10.3350/kjhep.2012.18.1.75
BACKGROUND/AIMS: Newly developed and potent antiviral agents suffer from the problem of drug resistance. Multidrug resistance is a major impediment in the treatment of patients with chronic hepatitis B (CHB).... -
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- The Efficacy and Safety of Telbivudine in Korean Patients with Chronic Hepatitis B
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Moon YM, Hwang SG, Kim BS, Rim KS, Cho M, Kim DJ, Han JY, Kim YS, Choi HS, Ahn SH
- KMID: 1776826
- Korean J Hepatol.
- 2007 Dec;13(4):503-512.
- doi: 10.3350/kjhep.2007.13.4.503
BACKGROUND AND AIMS: Telbivudine is an L-nucleoside analogue with potent antiviral activity against hepatitis B virus (HBV). Clinical trials have shown that telbivudine is more potent than lamivudine for... -
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