- Long-Term Outcomes of Deep Brain Stimulation in Pantothenate Kinase-Associated Neurodegeneration-Related Dystonia
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Woo KA, Kim HJ, Jeon SH, Park HR, Park KW, Lee SH, Chung SJ, Chae JH, Paek SH, Jeon B
- KMID: 2533688
- J Mov Disord.
- 2022 Sep;15(3):241-248.
- doi: 10.14802/jmd.22002
Objective To investigate the long-term clinical outcomes of pallidal deep brain stimulation (GPi-DBS) in patients with pantothenate kinase-associated neurodegeneration (PKAN). Methods We reviewed the records of patients with genetically confirmed PKAN... -
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- Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum in vivo
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Hong AR, Jang JG, Chung YC, Won SY, Jin BK
- KMID: 2526965
- Exp Neurobiol.
- 2022 Feb;31(1):42-53.
- doi: 10.5607/en21032
To explore the potential function of interleukin-13 (IL-13), lipopolysaccharide (LPS) or PBS as a control was unilaterally microinjected into striatum of rat brain. Seven days after LPS injection, there was... -
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- Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury
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Lee SE, Yang H, Sung Y, Kim Y, Park SA
- KMID: 2519890
- Exp Neurobiol.
- 2021 Aug;30(4):285-293.
- doi: 10.5607/en21022
Apolipoprotein E (apoE) plays a role in various physiological functions including lipid transport, synaptic plasticity, and immune modulation. Epidemiological studies suggest that the apoE4 allele increases the risk of post-traumatic sequelae.... -
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- Asymmetric Amyloid-β Burden and Neurodegeneration in Late-Onset Alzheimer’s Disease Dementia
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Lee J, Kim HN, Kim MH, Shin IJ, Lee K, Kim YS, Lee SM, Moon SY
- KMID: 2518941
- J Korean Neurol Assoc.
- 2021 Aug;39(3):197-201.
- doi: 10.17340/jkna.2021.3.15
We report herein a 78-year-old woman with insidiously progressive cognitive impairment and asymmetric amyloid deposition and neurodegeneration. Brain magnetic resonance imaging revealed remarkable atrophy in the right-sided temporal lobe and... -
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- Microvasculature and Nerve Fiber Layer-Ganglion Cell Inner Plexiform Layer Thickness in Type 2 Diabetes
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Seo JS, Cho YW, Seo SW, Kim SJ, Chung IY, Yoo WS
- KMID: 2516803
- J Korean Ophthalmol Soc.
- 2021 Jun;62(6):769-776.
- doi: 10.3341/jkos.2021.62.6.769
Purpose: To investigate thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and vessel density of the superficial and deep retinal vessels and choriocapillaris using swept source... -
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- Changes in Cerebral Gray and White Matter in Patients with Pantothenate Kinase-Associated Neurodegeneration: A Long-Term Magnetic Resonance Imaging Follow-Up Study
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Roa-Sanchez P, Bido P, Oviedo J, Huppertz HJ, Speckter H, Stoeter P
- KMID: 2516388
- J Mov Disord.
- 2021 May;14(2):148-152.
- doi: 10.14802/jmd.20102
Objective To determine the volume changes in gray and white matter during a long-term follow-up in patients suffering from pantothenate kinase-associated neurodegeneration (PKAN). Methods Magnetic resonance imaging was repeated in 13... -
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- Alpha-Synuclein Inclusion Formation in Human Oligodendrocytes
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Yoon YS, Ahn WJ, Ricarte D, Ortiz D, Shin CY, Lee SJ, Lee HJ
- KMID: 2510128
- Biomol Ther.
- 2021 Jan;29(1):83-89.
- doi: 10.4062/biomolther.2020.081
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by presence of α-synuclein-positive inclusions in the cytoplasm of oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are considered an integral part of... -
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- Lead acetate- induced neurodegenerative changes in the dorsolateral prefrontal cortex of mice: the role of Vitexin
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Amedu NO, Omotoso GO
- KMID: 2501919
- Environ Anal Health Toxicol.
- 2020 Mar;35(1):e2020001.
- doi: 10.5620/eaht.e2020001
This study was aimed at investigating the neuroprotective effect of Vitexin against lead (Pb) induced neurodegenerative changes in the dorsolateral prefrontal cortex (DLPFC) and working memory in mice. Thirty-two adolescent... -
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- Methyl-CpG Binding Protein 2 in Alzheimer Dementia
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Kim B, Choi Y, Kim HS, Im HI
- KMID: 2467315
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S72-S81.
- doi: 10.5213/inj.1938196.098
Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)... -
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- Cholesterol Metabolism in the Brain and Its Association with Parkinson's Disease
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Jin U, Park SJ, Park SM
- KMID: 2463711
- Exp Neurobiol.
- 2019 Oct;28(5):554-567.
- doi: 10.5607/en.2019.28.5.554
Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the aging population after Alzheimer’s disease (AD). Defects in the lysosomal systems and mitochondria have been suspected to cause... -
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- Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy
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Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H
- KMID: 2451072
- Exp Neurobiol.
- 2019 Jun;28(3):362-375.
- doi: 10.5607/en.2019.28.3.362
Chronic traumatic encephalopathy (CTE) is a distinct neurodegenerative disease that associated with repetitive head trauma. CTE is neuropathologically defined by the perivascular accumulation of abnormally phosphorylated tau protein in the... -
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- A Patient with Beta-Propeller Protein-Associated Neurodegeneration: Treatment with Iron Chelation Therapy
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Lim SY, Tan AH, Ahmad-Annuar A, Schneider , Bee PC, Lim JL, Ramli N, Idris MI
- KMID: 2413381
- J Mov Disord.
- 2018 May;11(2):89-92.
- doi: 10.14802/jmd.17082
We present a case of beta-propeller protein-associated neurodegeneration, a form of neurodegeneration with brain iron accumulation. The patient harbored a novel mutation in the WDR45 gene. A detailed video and... -
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- Botulinum Toxin-A Injection in the Treatment of Spasticity in a Infantile-Onset Neurodegeneration With Brain Iron Accumulation: A Case Report
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Do HK, Jo GY, Kwon JK, Kim WJ
- KMID: 2432209
- Ann Rehabil Med.
- 2018 Apr;42(2):363-367.
- doi: 10.5535/arm.2018.42.2.363
Pantothenate kinase-associated neurodegeneration (PKAN) is a neurodegenerative disorder characterized by iron accumulation in the globus pallidus (GP) of the brain (neurodegeneration with brain iron accumulation [NBIA]), which is characterized by... -
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- Odor Enrichment Increases Hippocampal Neuron Numbers in Mouse
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Rusznák Z, Sengul G, Paxinos G, Kim WS, Fu Y
- KMID: 2410470
- Exp Neurobiol.
- 2018 Apr;27(2):94-102.
- doi: 10.5607/en.2018.27.2.94
The hippocampus and olfactory bulb incorporate new neurons migrating from neurogenic regions in the brain. Hippocampal atrophy is evident in numerous neurodegenerative disorders, and altered hippocampal neurogenesis is an early... -
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- Morphine-alcohol treatment impairs cognitive functions and increases neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats
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Adedayo AD, Aderinola , Adekilekun TA, Olaolu OO, Olanike AM, Olayemi IK
- KMID: 2418394
- Anat Cell Biol.
- 2018 Mar;51(1):41-51.
- doi: 10.5115/acb.2018.51.1.41
In the developed and developing world, opioid consumption in combination with alcohol has become one of the substances abused. In this experiment, we examined the effects of alcohol, morphine, and... -
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- In Vivo Assessment of Neurodegeneration in Type C Niemann-Pick Disease by IDEAL-IQ
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Guo RM, Li QL, Luo ZX, Tang W, Jiao J, Wang J, Kang Z, Chen SQ, Zhang Y
- KMID: 2425114
- Korean J Radiol.
- 2018 Feb;19(1):93-100.
- doi: 10.3348/kjr.2018.19.1.93
OBJECTIVE: To noninvasively assess the neurodegenerative changes in the brain of patients with Niemann-Pick type C (NPC) disease by measuring the lesion tissue with the iterative decomposition of water and... -
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- PSEN1 p.Met233Val in a Complex Neurodegenerative Movement and Neuropsychiatric Disorder
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Appel-Cresswell S, Guella I, Lehman A, Foti D, Farrer MJ
- KMID: 2405202
- J Mov Disord.
- 2018 Jan;11(1):45-48.
- doi: 10.14802/jmd.17066
Mutations in presenilin 1 (PSEN1) are the most common cause of autosomal dominant Alzheimer's disease. Here, we report a Canadian-Vietnamese family carrying a PSEN1 p.Met233Val mutation with an exceptionally early... -
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- Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling
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Jiang T, Wang XQ, Ding C, Du XL
- KMID: 2395252
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):579-589.
- doi: 10.4196/kjpp.2017.21.6.579
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies... -
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- Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
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Kocahan S, DoÄŸan Z
- KMID: 2367656
- Clin Psychopharmacol Neurosci.
- 2017 Feb;15(1):1-8.
- doi: 10.9758/cpn.2017.15.1.1
The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment, neuronal death and the loss of synapses, all... -
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- Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
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Kim C, Lee HJ, Masliah E, Lee SJ
- KMID: 2308636
- Exp Neurobiol.
- 2016 Jun;25(3):113-119.
- doi: 10.5607/en.2016.25.3.113
Synucleinopathies are a collection of neurological diseases that are characterized by deposition of α-synuclein aggregates in neurons and glia. These diseases include Parkinson's disease (PD), dementia with Lewy bodies, and... -
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