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Association of chloride-rich fluids and medication diluents on the incidence of hyperchloremia and clinical consequences in aneurysmal subarachnoid hemorrhage

Barlow B, Thompson Bastin ML, Shadler A, Cook AM

Background: Chloride-rich fluid administration is frequently employed in the management of aneurysmal subarachnoid hemorrhage (aSAH). However, the incidence and consequences of hyperchloremia in aSAH remain poorly defined. This study aimed...
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Prevalence and prediction of augmented renal clearance in the neurocritical care population

Cook AM, Li D, Nestor MA, Bastin MLT

Background: Augmented renal clearance (ARC; creatinine clearance [CrCl] >130 mL/min/1.73 m2) is prevalent in patients with neurological injuries and may influence their exposure to important pharmacological therapies. Little is known...
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Gut microbiome and neurocritically ill patients

Dono A, Esquenazi Y, Choi HA

Since the times of Rokitansky and Cushing, we have been fascinated by the connections between the gut and the brain. Recent advances in next-generation sequencing techniques have shown that this...
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Brain-lung interaction: a vicious cycle in traumatic brain injury

Chacón-Aponte AA, Durán-Vargas , Arévalo-Carrillo JA, Lozada-Martínez ID, Bolaño-Romero MP, Moscote-Salazar LR, Grille P, Janjua T

The brain-lung interaction can seriously affect patients with traumatic brain injury, triggering a vicious cycle that worsens patient prognosis. Although the mechanisms of the interaction are not fully elucidated, several...
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Basic considerations on magnesium in the management of neurocritical patients

Lozada-Martinez ID, Padilla-Durán TJ, González-Monterroza JJ, Aguilar-Espinosa DA, Molina-Perea KN, Camargo-Martinez W, Llamas-Medrano L, Hurtado-Pinillos M, Guerrero-Mejía A, Janjua T, Moscote-Salazar LR

Magnesium is an essential chemical element in human life. In the brain, it is physiologically responsible for a large number of processes involved in intracellular homeostasis, blood-brain barrier integrity, protein...
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Utility of medical simulation in neurovascular critical care education

Mass-Ramírez S, Vergara-Burgos H, Sierra-Ochoa C, Lozada-Martinez ID, Moscote-Salazar LR, Janjua T, Rahman MM, Rahman S, Picón-Jaimes YA

Simulation has shown good results in medical scenarios in which the patient's problem can be solved by following protocols previously established in clinical practice guidelines. Therefore, the implementation of simulation...
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Hiccups in neurocritical care

Rajagopalan V, Sengupta D, Goyal K, Dube SK, Bindra A, Kedia S

Hiccups are usually self-limiting and benign but can be distressing when they become persistent or intractable and produce significant morbidity. In the intubated patients in neurocritical care, persistent hiccups may...
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Targeted temperature management for postcardiac arrest syndrome

Kuroda Y, Kawakita K

Neurocritical care management to improve neurologic outcome for postcardiac arrest syndrome (PCAS) has focused considerably on targeted temperature management (TTM). TTM attenuates the destructive processes following ischemia/reperfusion in PCAS. The...
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