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Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2

Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH

  • KMID: 1110121
  • Exp Mol Med.
  • 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12...
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Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG

  • KMID: 1105280
  • Exp Mol Med.
  • 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,...
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