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Induced neural stem cells from human patient-derived fibroblasts attenuate neurodegeneration in Niemann-Pick type C mice

Hong S, Lee SE, Kang I, Yang J, Kim H, Kim J, Kang KS

Background: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive...
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Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an In Vitro Model of Alzheimer's Disease by Reducing NLRP-3 Inflammasome

Hwang M, Song Sh, Chang MS, Koh SH

Background and Purpose: Neural stem cells (NSCs) have the ability to regenerate, proliferate, and differentiate, enabling them to play important roles in the recovery of the damaged nervous system. However,...
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The Role of Lysophosphatidic Acid in Adult Stem Cells

Lee D, Kim YH, Kim JH

Stem cells are undifferentiated multipotent precursor cells that are capable both of perpetuating themselves as stem cells (self-renewal) and of undergoing differentiation into one or more specialized types of cells....
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Cellular Response of Ventricular-Subventricular Neural Progenitor/Stem Cells to Neonatal Hypoxic-Ischemic Brain Injury and Their Enhanced Neurogenesis

Shin JE, Lee H, Jung K, Kim M, Hwang K, Han J, Lim J, Kim IS, Lim KI, Park KI

Purpose: To elucidate the brain’s intrinsic response to injury, we tracked the response of neural stem/progenitor cells (NSPCs) located in ventricular-subventricular zone (V-SVZ) to hypoxic-ischemic brain injury (HI). We also...
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Intracerebral Transplantation of BDNF-overexpressing Human Neural Stem Cells (HB1.F3.BDNF) Promotes Migration, Differentiation and Functional Recovery in a Rodent Model of Huntington’s Disease

Kim HS, Jeon I, Noh JE, Lee H, Hong KS, Lee N, Pei Z, Song J

  • KMID: 2500524
  • Exp Neurobiol.
  • 2020 Apr;29(2):130-137.
  • doi: 10.5607/en20011
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by abnormally expanded CAG repeats in the huntingtin gene. The huntingtin gene mutation leads to the progressive degeneration of striatal...
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Robust and Reproducible Generation of Induced Neural Stem Cells from Human Somatic Cells by Defined Factors

Kwak TH, Hali S, Kim S, Kim J, La H, Kim KP, Hong KH, Shin CY, Kim NH, Han DW

Background and Objectives: Recent studies have described direct reprogramming of mouse and human somatic cells into induced neural stem cells (iNSCs) using various combinations of transcription factors. Although iNSC technology...
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Current Status and Future Strategies to Treat Spinal Cord Injury with Adult Stem Cells

Jeong SK, Choi I, Jeon SR

Spinal cord injury (SCI) is one of the most devastating conditions and many SCI patients suffer neurological sequelae. Stem cell therapies are expected to be beneficial for many patients with...
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Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions

Yun Y, Baek D, Lee D, Cheong E, Kim J, Oh J, Ha Y

Background: Gene therapy shows the ability to restore neuronal dysfunction via therapeutic gene expression. The efficiency of gene expression and delivery to hypoxic injury sites is important for successful gene...
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Notch Signaling Controls Oligodendrocyte Regeneration in the Injured Telencephalon of Adult Zebrafish

Kim HK, Lee Dw, Kim E, Jeong I, Kim S, Kim BJ, Park HC

  • KMID: 2510504
  • Exp Neurobiol.
  • 2020 Dec;29(6):417-424.
  • doi: 10.5607/en20050
The myelination of axons in the vertebrate nervous system through oligodendrocytes promotes efficient axonal conduction, which is required for the normal function of neurons. The central nervous system (CNS) can...
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A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models

Heo JR, Hwang KA, Kim SU, Choi KC

PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into...
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Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells

Ha S, Jeong SH, Yi K, Chu JJ, Kim S, Kim EK, Yu SW

Neural stem cells (NSCs) have the ability to self-renew and differentiate into neurons, oligodendrocytes, and astrocytes. Highly dynamic nature of NSC differentiation requires the intimate involvement of catabolic processes such...
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Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation

Lee HJ, Choi NY, Lee SW, Lee Y, Ko K, Kim GJ, Hwang HS, Ko K

BACKGROUND AND OBJECTIVES: Genomic imprinting modulates growth and development in mammals and is associated with genetic disorders. Although uniparental embryonic stem cells have been used to study genomic imprinting, there...
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Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

Shin JE, Han J, Lim JH, Eun HS, Park KI

Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury...
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Regulation of Neural Stem Cell Fate by Natural Products

Kim HJ

Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent...
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Neural Stem Cell Differentiation Using Microfluidic Device-Generated Growth Factor Gradient

Kim JH, Sim J, Kim HJ

Neural stem cells (NSCs) have the ability to self-renew and differentiate into multiple nervous system cell types. During embryonic development, the concentrations of soluble biological molecules have a critical role...
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Role of Carbon Monoxide in Neurovascular Repair Processing

Choi YK

Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In...
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The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro

Moon BS, Ammothumkandy A, Zhang N, Peng L, Ibrayeva A, Bay M, Pratap A, Park HJ, Bonaguidi , Lu W

OBJECTIVES: Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown....
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Candesartan Restores the Amyloid Beta-Inhibited Proliferation of Neural Stem Cells by Activating the Phosphatidylinositol 3-Kinase Pathway

Choi H, Choi NY, Lee KY, Lee YJ, Koh SH

BACKGROUND AND PURPOSE: Neurogenesis in the adult brain is important for memory and learning, and the alterations in neural stem cells (NSCs) may be an important aspect of Alzheimer's disease...
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Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells

Eghlidospour M, Ghanbari A, Mortazavi , Azari H

Due to the importance of neural stem cells (NSCs) in plasticity of the nervous system and treating neurodegenerative diseases, the main goal of this study was to evaluate the effects...
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Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor

Hwang Y, Kim D, Chang D, Ahn B, Kim YB, Kim G

This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared...
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