- Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs
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Rajasekaran S, Soundararajan DCR, Nayagam SM, Tangavel C, Raveendran M, K S SVA, Shetty AP, Kanna RM
- KMID: 2539740
- Asian Spine J.
- 2023 Feb;17(1):17-29.
- doi: 10.31616/asj.2021.0535
Study Design: Profiling proteins expressed in the nucleus pulposus (NP) of intervertebral discs (IVDs) in five different biological states. Purpose: To evaluate the molecular complexity of the collagen (COL) framework and... -
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- Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma
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Rajasekaran S, Tangavel C, Soundararajan DCR, Nayagam SM, Matchado MS, Muthurajan R, Anand KSV, Rajendran S, Shetty AP, Kanna RM, Kuppamuthu D
- KMID: 2503418
- Neurospine.
- 2020 Jun;17(2):426-442.
- doi: 10.14245/ns.2040056.028
Objective: To catalog and characterize the proteome of normal human intervertebral disc (IVD). Methods: Nine magnetic resonance imaging (MRI) normal IVDs were harvested from 9 different brain dead yet alive voluntary... -
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- Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
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Rajasekaran S, Soundararajan DCR, Tangavel C, K. S. SVA, Nayagam SM, Matchado MS, Muthurajan R, Shetty AP, Kanna RM, Dharmalingam K
- KMID: 2505234
- Asian Spine J.
- 2020 Aug;14(4):409-420.
- doi: 10.31616/asj.2019.0217
Study Design: Profiling proteins expressed in the nucleus pulposus of fetal intervertebral disc (IVD). Purpose: To evaluate the molecular complexity of fetal IVDs not exposed to mechanical, traumatic, inflammatory, or infective... -
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