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Natural Products Targeting Wnt/β-catenin Signaling Pathway

Kim D, Lee SK

The canonical Wnt/β-catenin signaling pathways play an important role in the embryonic development, cell proliferation, differentiation, and adhesion. Therefore, the abnormal activation and repression have been associated with uncontrolled homeostasis...
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NMR Assignments of Rotameric Aporphine Alkaloids from Liriodendron tulipifera

Park I, Na M

Liriodendron tulipifera, belonging to the family Magnoliaceae, is commonly called tulip tree. Four N-acetylated aporphine alkaloids, N-acetylnornuciferine (1), N-acetylanonaine (2), N-acetyl-3-methoxynornuciferine (3), and N-acetyl-3-methoxynornantenine (4) were isolated from the roots...
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Terpenoids from Citrus unshiu Peels and Their Effects on NO Production

Vu TO, Seo W, Lee JH, Min BS, Kim JA

Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1ʺ→2ʹ)-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels ofCitrus unshiu Markov. Their structures were elucidated based on extensive NMR...
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Anti-Helicobacter pylori Activity of Compounds Isolated from Fraxinus mandshurica Bark

Akter KM, Kim HJ, Park WS, Khalil AAK, Ahn MJ

Helicobacter pylori is a well-known pathogen that is responsible for gastric disorders. Overcoming of the antibiotic-resistance is a main barrier to treat H. pylori infection. In our search for anti-H....
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Mushrooms: An Important Source of Natural Bioactive Compounds

Ha JW, Kim J, Kim H, Jang W, Kim KH

Mushrooms are known for their various attributes in the fields of nutrition and therapeutics. With exceptional taste, aroma, and nutritional value, they are considered ‘functional food’-improving health and providing nutritional...
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Presence of Two Apocarotenoids in Volatile Constituents of Onosma dichroanthum

Mousavi SP, Motamed SM

Volatile constituents obtained by water distillation from the aerial parts and root of Onosma dichroanthum Boiss (Boraginaceae) native to the north of Iran were investigated by GC and GC/MS for...
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Phytochemical Constituents of Phyllanthus urinaria

Cha JM, Park JE, Choi SU, Lee KR

Extensive column chromatography separation of the MeOH extract from the aerial parts of Phyllanthus urinaria afforded seventeen compounds (1 - 17). The structures of the compounds were elucidated by physicochemical...
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Chemical Constituents of Nauclea vanderguchtii

Nkouayeb BMN, Azebaze AGB, Tabekoueng GB, Tekapi Tsopgni WD, Lenta BN, Frese M, Sewald N, Vardamides JC

Phytochemical investigation of leaves, barks and roots of Nauclea vanderguchtii led to the isolation of sixteen compounds, which includes one citric acid derivative (2), one alkaloid (16), one peptide derivative...
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Butyrylcholinesterase Inhibitory Activity and GC-MS Analysis of Carica papaya Leaves

Khaw KY, Yeou Chear NJ, Maran S, Yeong KY, Ong YS, Goh BH

Carica papaya is a medicinal and fruit plant owing biological activities including antioxidant, antiviral, antibacterial and anticancer. The present study aims to investigate the acetyl (AChE) and butyryl (BChE) cholinesterase...
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Persicaria senticosa Ameliorates Imiquimod-induced Psoriasis-like Skin Lesions in Mice via Suppression of IL-6/STAT3 Expression and Proliferation of Keratinocytes

Jung S, Park JR, Ra M, Kim YH, Yu JH, Lee Y

Psoriasis is one of the most common inflammatory skin disorders, with a global prevalence of 2% – 3%. It is an autoimmune skin disorder characterized by excessive generation of plaques...
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