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Establishment of a eNOS Gene Therapy Model Using PLGA Nanosphere in Spontaneous Hypertensive Rat

Shim TJ, Choi EJ, Park KJ, Kim YJ, Kim SJ, Lee SY, Kim SM, Bae JW, Hwang KK, Kim DW, Cho MC

  • KMID: 2012310
  • J Korean Soc Hypertens.
  • 2010 Jun;16(2):28-38.
BACKGROUND: Poly(lactic-co-glycolic acid) (PLGA) has been studied for many years as a suitable drug delivery material, because of its chemical biocompatibility, total biodegradability, and non-toxic degradation products. The aim of...
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A Case of Warfarin-Induced Bleeding in a Patient with CYP2C9 and VKORC1 Gene Polymorphism, Detected by a Point-of-Care Gene Test Device

Kim BS, Lee DH, Park HK, Kim M, Kim SH, Kim KH, Kim MH

  • KMID: 2267834
  • Korean J Med.
  • 2013 Jul;85(1):87-91.
A 69-year-old female Korean patient was initially prescribed warfarin for the prevention of systemic thromboembolism due to atrial fibrillation. One month later, multiple bruises and subcutaneous hematomas were evident, and...
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Evaluation of the Verigene Warfarin Metabolism Nucleic Acid Test Kit for the Rapid Detection of CYP2C9 and VKORC1 Polymorphisms

Lee H, Kim J, Lee GD, Park J, Chae H, Kim M, Kim Y, Oh YS

BACKGROUND: Warfarin is a widely used oral agent for anticoagulation therapy. Warfarin has a narrow therapeutic index and a wide variation in the interindividual therapeutic dosage. Recently, genotypes of CYP2C9...
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Safety and efficacy of polycaprolactone copolymer nanosphere hydrogel injected into the scalp dermal tissue of rats

Lee SJ, Lee WS, Chung CH

BACKGROUND: Currently, dermal fillers need to be 25 µm or larger to reduce in vivo degradation by macrophages. However, the large size of fillers may cause side effects, including interruption...
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