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A Case of Multicentric Castleman's Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab

Higuchi T, Nakanishi , Takada K, Matsumoto , Okada M, Horikoshi , Suzuki K

This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with...
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A case report of a long-term abandoned torn lingual nerve injury repaired by collagen nerve graft induced by lower third molar extraction

Fujita S, Mizobata N, Nakanishi , Tojyo I

BACKGROUND: The lingual nerve plays an important role in multiple functions, including gustatory sensation and contact sensitivity and thermosensitivity. Misdiagnosed conservative treatments for serious lingual nerve (LN) injuries can induce...
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Effect of Biopsy Technique on the Survival Rate of Malignant Melanoma Patients

Yamashita , Hashimoto , Abe Y, Seike T, Okawa K, Senzaki Y, Murao K, Kubo Y, Nakanishi

BACKGROUND: Cutaneous malignant melanoma has a poor prognosis. The detrimental effect of incisional biopsies on the outcome of malignant melanoma has been debated. The aim of this study was to...
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Novel Hybrid Hydroxyapatite Spacers Ensure Sufficient Bone Bonding in Cervical Laminoplasty

Tanaka N, Nakanishi , Kamei N, Nakamae T, Kotaka S, Fujimoto Y, Ochi M, Adachi N

STUDY DESIGN: Prospective observational study. PURPOSE: This prospective analysis aimed to evaluate the efficacy and bone-bonding rate of hybrid hydroxyapatite (HA) spacers in expansive laminoplasty. OVERVIEW OF LITERATURE: Various types of spacers...
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Risk of lingual nerve injuries in removal of mandibular third molars: a retrospective case-control study

Tojyo I, Nakanishi , Shintani Y, Okamoto K, Hiraishi Y, Fujita S

BACKGROUND: Through the analysis of clinical data, we attempted to investigate the etiology and determine the risk of severe iatrogenic lingual nerve injuries in the removal of the mandibular third...
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Effect of duration from lingual nerve injury to undergoing microneurosurgery on improving sensory and taste functions: retrospective study

Nakanishi , Yamamoto Y, Tanioka K, Shintani Y, Tojyo I, Fujita S

BACKGROUND: The prognosis of recovery following microneurosurgery for injured lingual nerves varies among individual cases. This study aimed to investigate if recovery ratios of sensory and taste functions are improved...
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Luteal lifespan and fertility after estrus synchronization in goats

Chao LM, Takayama K, Nakanishi , Hamana K, Takagi M, Kubota C, Kojima T

The present experiment aims to examine the efficiency of estrus synchronization using progesterone and equine chorionic gonadotrophin (eCG) and to look at luteal function. During the non-breeding and breeding season,...
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Evaluation of the results of oral food challenges conducted in specialized and general hospitals

Sakai K, Sasaki K, Furuta T, Sugiura S, Watanabe Y, Kobayashi , Kawabe T, Morishita , Nakanishi , Ito K

BACKGROUND: Oral food challenge (OFC) tests are conducted in both specialized institutions and general hospitals. We aimed to compare the severity of the conditions of the patients between these 2...
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PD-L1 expression correlated with p53 expression in oral squamous cell carcinoma

Tojyo I, Shintani Y, Nakanishi , Okamoto K, Hiraishi Y, Fujita S, Enaka M, Sato F, Muragaki Y

BACKGROUND: Programmed cell death ligand 1 (PD-L1) is an immune checkpoint molecule that attenuates the immune response. PD-L1 contributes to failed antitumor immunity; thereby, blockade of PD-L1 with monoclonal antibody...
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iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia

Li L, Roh JH, Chang EH, Lee Y, Lee S, Kim M, Koh W, Chang JW, Kim HJ, Nakanishi , Barker RA, Na DL, Song J

Disease modeling of Alzheimer's disease (AD) has been hampered by the lack of suitable cellular models while animal models are mainly based on the overexpression of AD-related genes which often...
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Associations between Japanese schoolchildren's involvement in at-home meal preparation, their food intakes, and cooking skills

Nozue M, Ishida H, Hazano S, Nakanishi , Yamamoto T, Abe A, Nishi N, Yokoyama T, Murayama N

BACKGROUND/OBJECTIVES: This study aimed to examine the association of Japanese schoolchildren's involvement in at-home meal preparation with food intake and cooking skill. SUBJECTS/METHODS: We included 1,207 fifth-grade children aged 10-11 years...
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Risk Factors for Complications after Reconstructive Surgery for Sternal Wound Infection

Hashimoto , Takaku M, Matsuo S, Abe Y, Harada H, Nagae H, Fujioka Y, Anraku K, Inagawa K, Nakanishi

BACKGROUND: Although the utility of flaps for the treatment of sternal wound infections following median sternotomy has been reported for 30 years, there have been few reports on the risk...
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The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction

Li L, Roh JH, Kim HJ, Park HJ, Kim M, Koh W, Heo H, Chang JW, Nakanishi , Yoon T, Na DL, Song J

Alzheimer's Disease (AD) is a progressive neurodegenerative disease, which is pathologically defined by the accumulation of amyloid plaques and hyper-phosphorylated tau aggregates in the brain. Mitochondrial dysfunction is also a...
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