- Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase
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Xu Z, Liang H, Zhang M, Tao X, Dou D, Hu L, Kang T
- KMID: 2395255
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):609-616.
- doi: 10.4196/kjpp.2017.21.6.609
Ardipusilloside-I is a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in... -
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- Role of Rho-Kinase Activity in Angiotensin II-Induced Contraction of Corpus Cavernosum Smooth Muscle in the Rabbit
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Kim MK, Park JK
- KMID: 2145847
- Korean J Androl.
- 2003 Apr;21(1):32-37.
PURPOSE: RhoA/Rho-kinase regulates vascular tone via a calcium sensitization mechanism. Stimulation of the AT1 receptor by angiotensin (ANG) II activates the Rho A/Rho-kinase signaling pathway. However, its role in corpus... -
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- Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
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Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
- KMID: 1111411
- Exp Mol Med.
- 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the... -
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- Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase
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Zhang J, Qiao Y, Le J, Sun D, Guan Y, Li Z
- KMID: 2316621
- Psychiatry Investig.
- 2016 Mar;13(2):232-238.
- doi: 10.4306/pi.2016.13.2.232
OBJECTIVE: To study whether the effects of olanzapine on gastrointestinal motility is related to the serotonin antagonism and myosin light chain kinase. METHODS: Male Sprague-Dawley rats were randomly divided into four... -
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- Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats
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Yu C, Xiong Y, Chen D, Li Y, Xu B, Lin Y, Tang Z, Jiang C, Wang L
- KMID: 2371062
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):1-9.
- doi: 10.4196/kjpp.2017.21.1.1
Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal inflammation and co-occurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is used to... -
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- Altered Gene Expression in Cerulein-Stimulated Pancreatic Acinar Cells: Pathologic Mechanism of Acute Pancreatitis
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Yu JH, Lim JW, Kim H
- KMID: 2285374
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):409-416.
- doi: 10.4196/kjpp.2009.13.6.409
Acute pancreatitis is a multifactorial disease associated with the premature activation of digestive enzymes. The genes expressed in pancreatic acinar cells determine the severity of the disease. The present study... -
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- G protein-coupled receptor signaling in gastrointestinal smooth muscle
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Sohn UD, Kim DS, Murthy KS
- KMID: 2071568
- Korean J Physiol Pharmacol.
- 2001 Aug;5(4):287-297.
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2+ leading to activation of Ca2+/calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms... -
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- Changes in cytosolic Ca2+ but not in cGMP contents may be more important to nitric oxide-mediated relaxation in depolarized vascular smooth muscle
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Lee HS, Chang KC
- KMID: 2071525
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):63-68.
Nitric oxide (NO)-mediated relaxation in vascular smooth muscle involves not only activation of guanylate cyclase but also hyperpolarization of the membrane. It has been shown that depolarization decreases the (Ca2+) sensitivity of myosin... -
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- MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle
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Park SY, Shim JH, Kim M, Sun YH, Kwak HS, Yan X, Choi BC, Im C, Sim SS, Jeong JH, Kim IK, Min YS, Sohn UD
- KMID: 1457698
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):29-35.
- doi: 10.4196/kjpp.2010.14.1.29
We have shown that myosin light chain kinase (MLCK) was required for the off-contraction in response to the electrical field stimulation (EFS) of feline esophageal smooth muscle. In this study,... -
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- Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages
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Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB
- KMID: 1116203
- Exp Mol Med.
- 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis... -
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