- Decreased inward rectifier and voltage-gated K⺠currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats
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Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ
- KMID: 2466575
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):111-119.
- doi: 10.4196/kjpp.2020.24.1.111
In vascular smooth muscle, K⺠channels, such as voltage-gated K⺠channels (Kv), inward-rectifier K⺠channels (Kir), and big-conductance Ca²âº-activated K⺠channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the... -
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- Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
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Jorgensen , Ro S
- KMID: 2454636
- J Neurogastroenterol Motil.
- 2019 Jul;25(3):377-386.
- doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has... -
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- Benefits of Angiotensin Receptor Blockade: Preventing Smooth Muscle Cell Senescence and Beyond
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Song P, Kim JH
- KMID: 2450394
- Korean Circ J.
- 2019 Jul;49(7):627-628.
- doi: 10.4070/kcj.2019.0164
No abstract available. -
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- Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells
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Lee DK, Min YS, Yoo SS, Shim HS, Park SY, Sohn UD
- KMID: 2427507
- Biomol Ther.
- 2018 Nov;26(6):546-552.
- doi: 10.4062/biomolther.2018.053
A comprehensive collection of proteins senses local changes in intracellular Ca²⺠concentrations ([Ca²âº](i) and transduces these signals into responses to agonists. In the present study, we examined the effect of... -
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- Inhibition of voltage-dependent K⺠current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
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An JR, Li H, Seo MS, Park WS
- KMID: 2419009
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):597-605.
- doi: 10.4196/kjpp.2018.22.5.597
In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent K⺠(Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits.... -
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- Overexpression of miR-155-5p Inhibits the Proliferation and Migration of IL-13-Induced Human Bronchial Smooth Muscle Cells by Suppressing TGF-β-Activated Kinase 1/MAP3K7-Binding Protein 2
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Shi Y, Fu X, Cao Q, Mao Z, Chen Y, Sun Y, Liu Z, Zhang Q
- KMID: 2409061
- Allergy Asthma Immunol Res.
- 2018 May;10(3):260-267.
- doi: 10.4168/aair.2018.10.3.260
PURPOSE: Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease... -
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- Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent Kâ» channels in coronary arterial smooth muscle cells
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Kim HS, Li H, Kim HW, Shin SE, Seo MS, An JR, Ha KS, Han ET, Hong SH, Choi IW, Choi G, Lee DS, Park WS
- KMID: 2384455
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):415-421.
- doi: 10.4196/kjpp.2017.21.4.415
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K⺠(Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application... -
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- Cyclic Stretch Effects on Adipose-Derived Stem Cell Stiffness, Morphology and Smooth Muscle Cell Gene Expression
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Rabbani M, Tafazzoli-Shadpour M, Shokrgozar MA, Janmaleki , Teymoori M
- KMID: 2395084
- Tissue Eng Regen Med.
- 2017 Jun;14(3):279-286.
- doi: 10.1007/s13770-017-0033-6
Recent investigations consider adipose-derived stemcells (ASCs) as a promising source of stemcells for clinical therapies. To obtain functional cells with enhanced cytoskeleton and aligned structure, mechanical stimuli are utilized during... -
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- Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
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Shin SE, Li H, Kim HS, Kim HW, Seo MS, Ha KS, Han ET, Hong SH, Firth AL, Choi IW, Bae YM, Park WS
- KMID: 2371041
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):225-232.
- doi: 10.4196/kjpp.2017.21.2.225
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K⺠(Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a... -
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- Long Term Effect of High Glucose and Phosphate Levels on the OPG/RANK/RANKL/TRAIL System in the Progression of Vascular Calcification in rat Aortic Smooth Muscle Cells
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Kang YH, Jin JS, Son SM
- KMID: 2285562
- Korean J Physiol Pharmacol.
- 2015 Mar;19(2):111-118.
- doi: 10.4196/kjpp.2015.19.2.111
Osteoprotegerin (OPG), receptor activator of NF-kappaB ligand (RANKL)/receptor activator of NF-kappaB (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high... -
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- The Role of MicroRNAs in Vascular Diseases; Smooth Muscle Cell Differentiation and De-Differentiation
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Hwang KC
- KMID: 2223881
- Korean Circ J.
- 2014 Jul;44(4):218-219.
- doi: 10.4070/kcj.2014.44.4.218
No abstract available. -
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- Effects of Phytoestrogen on Potassium Channel Activities of Smooth Muscle Cells of Rabbit Seminal Vesicle
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Choi J, Ki SH, Kim YC, Kim TH
- KMID: 2226602
- Korean J Androl.
- 2007 Aug;25(2):72-78.
PURPOSE: This study was performed to determine the effects of phytoestrogen on seminal vesicle excitability. MATERIALS AND METHODS: Single smooth muscle cells of seminal vesicle were obtained from rabbits using... -
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- The Effect of Midazolam on Outward K+ Channel Currents in Rabbit Cerebral Arterial Smooth Muscle Cells
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Shin YC, Shim JH, Jeon WJ, Cho SY, Shin WJ, Kim KH, Yeom JH
- KMID: 2236645
- Korean J Anesthesiol.
- 2007 Jan;52(1):67-71.
- doi: 10.4097/kjae.2007.52.1.67
BACKGROUND: Midazolam has a direct relaxing effect on vascular smooth muscle, but the mechanisms that this agent produces muscle relaxation are not fully understood. The current study was performed to... -
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- Isolation of Endothelial Cells and Smooth Muscle Cells from Rat Aort
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Yun YE, Song IH, Sung EK, Kim JY
- KMID: 2049774
- Yeungnam Univ J Med.
- 2006 Dec;23(2):182-192.
- doi: 10.12701/yujm.2006.23.2.182
BACKGROUND: Atherosclerosis has emerged as the leading cause of death in developed countries. At present, human umbilical vein endothelial cells (HUVEC) are most commonly used for the investigation of Endothelial... -
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- Dexamethasone Attenuates PDGF- and TGF-beta-enhanced Vascular Endothelial Growth Factor Production in Cultured Human Bronchial Smooth Muscle Cells
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Yoo MH, Shim JY, Seo BG, Kim DS, Shim JW, Jung HL, Park MS
- KMID: 2314413
- Pediatr Allergy Respir Dis.
- 2006 Jun;16(2):142-149.
PURPOSE: Human bronchial smooth muscle cell(HBSMC) plays an important role in the remodeling of the airways in asthma. Vascular endothelial growth factor(VEGF) is a multifunctional cytokine, which induces edema, angiogenesis,... -
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- The Effect of Tyrosine Kinase Inhibitors on the L-type Calcium Current in Rat Basilar Smooth Muscle Cells
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Bai GY, Yang TK, Gwak YG, Kim CJ
- KMID: 1822236
- J Korean Neurosurg Soc.
- 2006 Mar;39(3):215-220.
OBJECTIVE: Tyrosine kinase inhibitors may be useful in the management of cerebral vasospasm. It has not yet been reported whether L-type Ca2+ channels play a role in tyrosine kinase inhibitors-induced... -
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- Conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death
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Bu MH, Lee KA, Kim KH, Rhim BY
- KMID: 2071613
- Korean J Physiol Pharmacol.
- 2005 Dec;9(6):315-322.
In this study, the authors investigated whether death of vascular smooth muscle cell (VSMC) had a pathological pertinence. Conditioned media obtained from rat aorta smooth muscle cell (SMC) that were... -
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- The Effect of Papaverine on the Calcium-dependent K+ Current in Rat Basilar Smooth Muscle Cells
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Bai GY, Cho JW, Han DH, Yang TK, Gwak YG, Kim CJ
- KMID: 1882180
- J Korean Neurosurg Soc.
- 2005 Nov;38(5):375-379.
OBJECTIVE: Papaverine has been used in treating vasospasm following subarachnoid hemorrhage(SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium channels are closely related to the contraction... -
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- Alpha-Lipoic acid Inhibits TNF-alpha-Induced Fractalkine Expression in Rat aortic Smooth Muscle Cells
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Park KG, Kim HS, Ryu SY, Nam CW, Chae BK, Jung ED, Kim JG, Kim BW, Lee IK
- KMID: 2008233
- J Korean Diabetes Assoc.
- 2005 Sep;29(5):409-417.
BACKGOUND: The induction of vascular inflammation via the proinflammatory cytokine/ nuclear factor (NF)-kappaB pathway is one of the key mechanisms in the development and progression of atherosclerosis. Accumulating evidence suggests... -
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- Ascochlorin Derivative, AS-6, Inhibits TNF-alpha-Induced fractalkine, MCP-1 and VCAM-1 Expression in Rat Aortic Smooth Muscle Cells
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Jang YY, Kim SY, Kim NK, Kim MK, Kim HK, Kim HS, Nam CW, Ryu SY, Nam SI, Park KG
- KMID: 2008232
- J Korean Diabetes Assoc.
- 2005 Sep;29(5):401-408.
BACKGOUND: Inflammation is one of the key mechanisms in the development and progression of atherosclerosis. Accumulating evidence suggests that peroxisome proliferators- activated receptorgamma(PPARgamma) plays an important role in the prevention... -
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