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Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats

Choi HS, Kim EJ, Kim MS, Myung JY, Yu MH, Kim YS, Lee MY

Background/Aims: Studies in healthy humans have reported that the addition of mosapride to acid suppressants resulted in higher intragastric pH than acid suppressant administration alone. We investigated the effect of...
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Multicenter, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of a Controlled-release, Once-daily UIC201609/UIC201610 Combination Therapy for Functional Dyspepsia: Preliminary Study

Lee JW, Youn YH, Choi SC, Lee KJ, Kim N

Background/Aims: Functional dyspepsia is a disease involving a range of upper gastrointestinal symptoms derived from various pathophysiologies. Tablets containing a combination of rabeprazole and controlled-release (CR) mosapride were recently developed. To...
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Efficacy and Safety of DWJ1252 Compared With Gasmotin in the Treatment of Functional Dyspepsia: A Multicenter, Randomized, Double-blind, Active-controlled Study

Park JH, Lee KN, Lee OY, Choi MG, Chung H, Choi SC, Kim N, Park H, Sung IK, Sohn CI, Jee SR, Jang JY, Rhee PL, Park MI, Kwon JG, Park KS, Lee KJ, Lee JS

  • KMID: 2510066
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):87-96.
  • doi: 10.5056/jnm20061
Background/Aims Prokinetics such as mosapride citrate CR (conventional-release; Gasmotin) are commonly used in functional dyspepsia (FD). This study aims to evaluate the efficacy and safety of once-a-day mosapride citrate SR (DWJ1252),...
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Mosapride Improves Lower Esophageal Sphincter and Esophageal Body Function in Patients With Minor Disorders of Esophageal Peristalsis

Kim SE, Park MI, Park SJ, Moon W, Kim JH, Jung K, Kwon HJ, Kim GM, Joo HK

  • KMID: 2500680
  • J Neurogastroenterol Motil.
  • 2020 Apr;26(2):232-240.
  • doi: 10.5056/jnm19062
Background/Aims High-resolution manometry (HRM) has broadened the awareness of minor esophageal peristaltic disorders. However, the treatments for these minor disorders are limited and the role of prokinetics has been controversial....
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Gastroprokinetic agent, mosapride inhibits 5-HT₃ receptor currents in NCB-20 cells

Park YS, Sung KW

Mosapride accelerates gastric emptying by acting on 5-hydroxytryptamine type 4 (5-HTâ‚„) receptor and is frequently used in the treatment of gastrointestinal (GI) disorders requiring gastroprokinetic efficacy. We tested the effect...
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Efficacy and Safety of UI05MSP015CT in Functional Dyspepsia: A Randomized, Controlled Trial

Yoon H, Lee DH, Lee YH, Jeong JC, Lee ST, Choi MG, Jeon SW, Shim KN, Baik GH, Kim JG, Moon JS, Sung IK, Lee SK, Rhee PL, Jung HY, Lee BE, Kim HS, Kim SG, Lee KM, Seong JK, Jang JS, Park JJ

BACKGROUND/AIMS: To evaluate the efficacy and safety of a controlled release, once-daily formulation of mosapride (UI05MSP015CT) in patients with functional dyspepsia (FD). METHODS: Patients with FD were randomly assigned (1:1) to...
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Symmetrical Drug-Related Intertriginous and Flexural Exanthema: Two Cases and Brief Literature Review

Seok J, Kim JM, Park KY, Seo SJ

It has been reported that there are a range of causative drugs related to symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). The causative drugs reported so far include the following:...
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Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay

Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM

Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA...
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The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut

Takaki M, Goto K, Kawahara I

  • KMID: 2381146
  • J Neurogastroenterol Motil.
  • 2014 Jan;20(1):17-30.
We explored a novel effect of 5-hydroxytryptamine 4 receptor (5-HT4R) agonists in vivo to reconstruct the enteric neural circuitry that mediates a fundamental distal gut reflex. The neural circuit insult...
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Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

Lim HC, Kim JH, Youn YH, Lee EH, Lee BK, Park H

  • KMID: 2325770
  • J Neurogastroenterol Motil.
  • 2013 Oct;19(4):495-502.
BACKGROUND/AIMS: Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used...
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Effects of 5-HT4 selective receptor agonist, mosapride citrate on electrocardiogram in dogs

Chae JS, Ahn JO, Coh YR, Park CW, Youn HY

  • KMID: 1435829
  • Korean J Vet Res.
  • 2012 Sep;52(3):163-167.
Mosapride stimulated dietary motility was introduced because of the arrhythmogenic effect of cisapride. Cisapride, 5-HT receptor agonist, induces prolongation of QT interval. Additionally, this condition can raise the possibility of...
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Effects of the Oral Administration of Mosapride Citrate on Capsule Endoscopy Completion Rate

Ida Y, Hosoe N, Imaeda H, Bessho R, Ichikawa R, Naganuma M, Kanai T, Hibi T, Ogata H

  • KMID: 2053496
  • Gut Liver.
  • 2012 Jul;6(3):339-343.
BACKGROUND/AIMS: In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate,...
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Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)

Sakamoto Y, Sekino Y, Yamada E, Ohkubo H, Higurashi , Sakai E, Iida H, Hosono K, Endo H, Nonaka T, Ikeda T, Fujita K, Yoneda M, Koide T, Takahashi , Goto A, Abe Y, Gotoh E, Maeda S, Nakajima A, Inamori M

  • KMID: 2325841
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):395-401.
BACKGROUND/AIMS: The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still...
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Endoscopic Evaluation of Gastric Emptying and Effect of Mosapride Citrate on Gastric Emptying

Jung IS, Kim JH, Lee HY, Park H, Lee SI

PURPOSE: Gastric emptying has been evaluated by scintigraphy in spite of its limitations of time consumption, cost, and danger of radioisotope. Endoscopy is a simple technique, however, its validation for...
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Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy

Okamura K, Sasaki N, Kikuchi T, Murata A, Lee I, Yamada H, Inokuma H

The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after...
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Effects of Mosapride Citrate on the Motility of Stomach, Ileum and Colon in Conscious Guinea Pigs

Park CI, Jung IS, Lim JH, Kim NK, Kim H, Park H

  • KMID: 2307471
  • Korean J Neurogastroenterol Motil.
  • 2007 Jun;13(1):53-60.
BACKGROUND/AIMS: Mosapride citrate (Mosapride) is a relatively new selective 5-HT4 receptor agonist. Several studies have reported that mosapride selectively stimulates the upper GI motility, but not lower GI motility. However,...
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Effect of Mosapride Citrate and Combined Treatment with Ondansetron on Postoperative Ileus in Rats

Kim YS, Oh JT, Kang DB, Kim KH, Choi CS, Lee MY, Choi SC

  • KMID: 2307457
  • Korean J Neurogastroenterol Motil.
  • 2007 Dec;13(2):138-145.
BACKGROUND/AIMS: Postoperative ileus (POI) is a transient impairment of gastrointestinal motility after surgery. The mechanisms of POI are not completely understood, but it has been accepted that an activation of...
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Effects of Mosapride on Upper Gastrointestinal Symptoms and Gastric Emptying in Patients with Functional Dyspepsia

Ji SW, Park H, Lee PR, Lee OY, Kim DK

  • KMID: 2255867
  • Korean J Neurogastroenterol Motil.
  • 2004 Jun;10(1):27-34.
BACKGROUND/AIMS: Mosapride is a new, prokinetic, 5-HT4 agonistic agent free of dopamine D2 receptor antagonist properties. The aim of this study was to evaluate the effects of mosapride on upper...
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The Effect of Mosapride on Quality of Life in Functional Dyspepsia

Cho YK, Choi MG, Kim SH, Lee IS, Kim SW, Chung IS, Lee SY, Choi SC, Seol SY

  • KMID: 772622
  • Korean J Gastroenterol.
  • 2004 Mar;43(3):160-167.
BACKGROUND/AIMS: It is unknown whether the prokinetics improve the quality of life in patients with functional dyspepsia. Thus, we evaluate the effect of the mosapride, selective 5-HT4 agonist, on...
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Investigation into the Effects of Mosapride on Motility of Guinea Pig Stomach, Ileum, and Colon

Ji SW, Park HJ, Cho JS, Lim JH, Lee SI

Mosapride citrate (Mosapride) is a new prokinetic agent that enhances the gastrointestinal (GI) motility by stimulation of 5-HT4 receptors. This agent stimulates acetylcholine release from enteric cholinergic neurons in the...
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