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Role of nitric oxide and molsidomine in the management of pulmonary hypertension in Takayasu's arteritis

Chin JY, Lee SS, Lee SS, Shim TS, Lim CM, Koh YS, Kim WS, Kim DS, Kim WD, Lee SD

We report three patients with pulmonary hypertension in Takayasu's arteritis, who showed long-term favorable response, clinically and hemodynamically, to the nitric oxide donor, molsidomine. In these patients, the inhaled nitric...
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The Effects of Oral Nitric Oxide Donor (Molsidomine) in Patients with Variant Angina Unresponsive to Conventional Anti-Anginal Drugs

Cho JH, Jeong MH, Park WS, Kim NH, Kim SH, Kim JW, Bae Y, Ahn YK, Park JH, Cho JG, Park JC, Kang JC

BACKGROUND: We observed the changes of clinical characteristics after oral Molsidomine, a nitric oxide donor, in patients who have documented coronary artery spasm by ergonovine coronary angiogram and refractory to...
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A Systematic Review on Drug Safety for Molsidomine, Nicorandil and Trimetazidine

Jeong KH, Lee E

BACKGROUND: Ischemic heart disease is the most common type of heart disease and an important cause of death in Korea. Among marketed anti-anginal medications, molsidomine, nicorandil, and trimetazidine are approved...
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The effects of antiproliferative drugs at stenotic area associated with primary atherosclerotic lesions in apoE knockout mouse - Change of vascular remodeling

Seo HS, Lee EM, Ahn JC, Kim SM, Hwang IH, Hwang KS, Song WH, Lim DS, Park CG, Kim YH, Shim WJ, Oh DJ, Ro YM

Apolipoprotein (apo) E deficient mouse can produce reproducible fixed stenotic primary atherosclerotic lesion, which reveals failure to remodel of vascular lumen, in the ascending aorta, external carotid, common carotid, iliac,...
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Nitric oxide-induced immune switching in experimental inflammatory autoimmune diseases

Kwak HJ, Kim HJ, Park JS, Jun CD, Lee MY, Shin TK, Chung HT

BACKGROUND: Nitric oxide (NO) production has been described as a double-edged sword eliciting both pro-and anti-inflammatory effect s in different immune reactions. This work was undertaken to investigate the immunoregulatory...
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Modulation of Ca2+ activated potassium channels by cGMP-dependent signal transduction mechanism in cerebral arterial smooth muscle cells of the rabbit

Han J, Kim N, Lee K, Kim E

  • KMID: 1581022
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):445-453.
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2+-activated potassium channel (KCa channel) and is involved in the activation of KCa channel...
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