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Follicular lymphoma: updates for pathologists

Khanlari M, Chapman JR

Follicular lymphoma (FL) is the most common indolent B-cell lymphoma and originates from germinal center B-cells (centrocytes and centroblasts) of the lymphoid follicle. Tumorigenesis is believed to initiate early in...
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Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group

Yoon S, Kim M, Hong YS, Kim HS, Kim ST, Kim J, Yun H, Yoo C, Ahn HK, Kim HS, Lee IH, Kim IH, Park I, Jeong JH, Cheon J, Kim JW, Yun J, Lim SM, Cha Y, Jang SJ, Zang DY, Kim TW, Kang JH, Kim JH

Next-generation sequencing (NGS) is becoming essential in the fields of precision oncology. With implementation of NGS in daily clinic, the needs for continued education, facilitated interpretation of NGS results and...
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Head-to-Head Comparison between Xpert MTB/RIF Assay and Real-Time Polymerase Chain Reaction Assay Using Bronchial Washing Specimens for Tuberculosis Diagnosis

Son E, Jang J, Kim T, Jang JH, Chung JH, Seol HY, Yeo HJ, Yoon SH, Lee SE, Cho WH, Kim YS, Jeon D

Background: With the introduction of Xpert MTB/RIF assay (Xpert), its incorporation into tuberculosis (TB) diagnostic algorithm has become an important issue. The aim of this study was to evaluate the...
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Comparison of the Data of a Next-Generation Sequencing Panel from K-MASTER Project with That of Orthogonal Methods for Detecting Targetable Genetic Alterations

Choi YJ, Choi JY, Kim JW, Lim AR, Lee Y, Chang WJ, Lee S, Sung JS, Chung HJ, Lee JW, Kang EJ, Kim JS, Lim T, Kim HS, Kim YJ, Ahn MS, Kim YS, Park JH, Lim S, Cho SS, Cho JH, Shin SW, Park KH, Kim YH

Purpose K-MASTER project is a Korean national precision medicine platform that screened actionable mutations by analyzing next-generation sequencing (NGS) of solid tumor patients. We compared gene analyses between NGS panel...
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β-Patchoulene: Conversion from Patchouli Alcohol by Acid Catalysts and its In silico Anti-inflammatory Study

F, Soekamto NH, Firdausiah S, Rasyid H, Rifai A

β-patchoulene (β-PAE) is a tricyclic sesquiterpene which performed many potential bioactivities and can be found in patchouli oil but in very low concentration. This study aimed to obtained β-PAE in...
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Systemic therapy for advanced hepatocellular carcinoma: consideration for selecting second-line treatment

Kim BH, Park JW

Several molecular-targeted agents have been tested as first- or second-line therapies for hepatocellular carcinoma (HCC) but failed to improve clinical outcomes; sorafenib has been the only approved systemic agent for...
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Report of the Korean Association of External Quality Assessment Service on Qualitative Testing of Molecular Virology (2016–2020)

Park , K, Kim MN, Sung H

For this study, we reviewed the surveys on qualitative testing of molecular virology conducted by the Korean Association of External Quality Assessment Service from 2016 to 2020. For this proficiency...
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Detection and molecular characteristics of bovine rotavirus A in dairy calves in China

Liu X, Yan N, Yue H, Wang Y, Zhang B, Tang C

Background Bovine group A rotavirus (BoRVA) is a major cause of severe gastroenteritis in newborn dairy calves. Only one study has investigated the G and P genotypes among dairy calves in...
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Metastasis prognostic factors and cancer stem cell-related transcription factors associated with metastasis induction in canine metastatic mammary gland tumors

Kim S, Bok E, Lee S, Lee HJ, Choe Y, Kim NH, Lee WJ, Rho GJ, Lee SL

Background Canine mammary gland tumor (MGT) is the most common cancer in aged female dogs. Although it's important to identify reliable metastasis or prognostic factors by evaluating related to cell division,...
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Molecular Identification of Cryptosporidium viatorum Infection in a Patient Suffering from Unusual Cryptosporidiosis in West Bengal, India

Sardar SK, Ghosal A, Saito-Nakano Y, Dutta S, Nozaki T, Ganguly S

In this study, we have collected and screened a total of 268 stool samples from diarrheal patients admitted to an Infectious disease hospital in Kolkata for the presence of Cryptosporidium...
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Distinctive morphological and molecular features of urothelial carcinoma with an inverted growth pattern

Sanguedolce F, Calò B, Chirico M, Falagario U, Busetto GM, Zanelli M, Bisagni A, Zizzo M, Ascani S, Carrieri G, Cormio L

Urothelial carcinoma with an inverted growth pattern (UC-IGP) is a peculiar entity within the spectrum of urothelial lesions. While efforts have been made over the last few decades to unravel...
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Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

Meng Q, Ning C, Wang L, Ren Y, Li J, Xiao C, Li Y, Li Z, He Z, Cai X, Qiao J

Background: Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a...
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Dynamic Contrast Enhanced MRI and Intravoxel Incoherent Motion to Identify Molecular Subtypes of Breast Cancer with Different Vascular Normalization Gene Expression

Tsai WC, Chang KM, Kao KJ

Objective: To assess the expression of vascular normalization genes in different molecular subtypes of breast cancer and to determine whether molecular subtypes with a higher vascular normalization gene expression can...
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Ononis spinosa alleviated capsaicin-induced mechanical allodynia in a rat model through transient receptor potential vanilloid 1 modulation

Jaffal SM, Al-Najjar BO, Abbas MA

Background: Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel implicated in pain sensation in response to heat, protons, and capsaicin (CAPS). It is well established that TRPV1...
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Implications of the simple chemical structure of the odorant molecules interacting with the olfactory receptor 1A1

Oh SJ

G protein–coupled receptors (GPCRs), including olfactory receptors, account for the largest group of genes in the human genome and occupy a very important position in signaling systems. Although olfactory receptors,...
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In Silico Analysis of Potential Antidiabetic Phytochemicals from Matricaria chamomilla L. against PTP1B and Aldose Reductase for Type 2 Diabetes Mellitus and its Complications

Hariftyani AS, Kurniawati LA, Khaerunnisa S, Veterini AS, Setiawati Y, Awaluddin R

Type 2 diabetes mellitus (T2DM) and its complications are important noncommunicable diseases with high mortality rates. Protein tyrosine phosphatase 1B (PTP1B) and aldose reductase inhibitors are recently approached and advanced...
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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics

Yoon JH, Kwon KS

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement...
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Blocking the interactions between human ACE2 and coronavirus spike glycoprotein by selected drugs: a computational perspective

Duru CE, Umar HIU, Duru IA, Enenebeaku UE, Ngozi-Olehi LC, Enyoh CE

The coronavirus disease of 2019 (COVID-19) has become a global pandemic with rapid rate of transmission and fatalities worldwide. Scientists have been investigating a host of drugs that may be...
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An Updated Review of Chronic Lymphocytic Leukemia

Cho HJ, Sohn SK

Chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cell accumulation and highly variable clinical manifestations that range from an indolent to an aggressive course, is rare in Korea. Asymptomatic patients with...
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Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience

Lee MY, Yoon SY, Kim KH, Lee N, Kim HY, Hwang JH, Won JH

Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment...
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