- Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide
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Nam HS
- KMID: 2449892
- J Stroke.
- 2019 May;21(2):151-159.
- doi: 10.5853/jos.2019.00472
Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases... -
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- Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
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Kant R, Bali A, Singh N, Jaggi AS
- KMID: 1429381
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):111-120.
- doi: 10.4196/kjpp.2013.17.2.111
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well... -
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- Cytochrome P-450 Dependent Hydroxylation of Chemical Carcinogens
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Hong YS
- KMID: 1969639
- Ewha Med J.
- 1979 Jun;2(2):75-82.
- doi: 10.12771/emj.1979.2.2.75
A large number of chemicals have the ability to induce cancer in a variety of tissues of various hosts, including man. Despite current interest in the viral etiology of a... -
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- Enhancement of O-dealkylation in Mouse Liver by Dietary Administrations of BHA and BHT: Studies with Isolated Perfused Livers and Hepatic Microsomes
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Ji SC, Conway JG, Thurman RG, Cha YN
- KMID: 693021
- Yonsei Med J.
- 1986 Jun;27(2):106-113.
- doi: 10.3349/ymj.1986.27.2.106
Effects of feeding 2(3)-tert-butyl 4-hydroxyanisole (BHA) and 3, 5-di-tert-butyl 4-hydroxytoluene (BHT) on the rates of mixed function oxidation and conjugation enzyme reactions have been determined using isolated hepatic microsomal fractions... -
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- CYP2C9 Mutation Affecting the Individual Variability of Warfarin Dose Requirement
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Kim YB, Ko MJ, Lee DG, Do JG, Hwang JH
- KMID: 2383663
- Ann Rehabil Med.
- 2012 Dec;36(6):857-860.
Warfarin is a frequently prescribed anticoagulant in rehabilitation patients. Adverse drug reactions of warfarin were reported as bleeding and cutaneous microvascular thrombosis. Major bleeding, such as intracranial hemorrhage and psoas... -
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- CYP1A2 activity as a risk factor for bladder cancer
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Lee SW, Jang IJ, Shin SG, Lee KH, Yim DS, Kim SW, Oh SJ, Lee SH
- KMID: 644840
- J Korean Med Sci.
- 1994 Dec;9(6):482-489.
- doi: 10.3346/jkms.1994.9.6.482
CYP1A2, CYP2D6 and N-acetyltransferase activities were estimated in 100 patients with bladder cancer and 84 control subjects from measurements of theophylline, metoprolol and isoniazid and their metabolites in urine, respectively.... -
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- Study on the Protective Effects of 6R-Tetrahydrobiopterin on the Oxidative Neuronal Injury in Mouse Cortical Cultures
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Moon KS, Lee JH, Kang SS, Kim SH, Kim JH, Jung S, Kim TS, Lee JK
- KMID: 2188696
- J Korean Neurosurg Soc.
- 2001 Sep;30(9):1059-1064.
OBJECTIVE: 6R-Tetrahydrobiopterin(BH4) is a cofactor for the aromatic amino acid hydroxylases which is essential for the biosynthesis of catecholamines and serotonin. It also acts as a cofactor for nitric oxide... -
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- Efficacy of Triple Therapy with Rabeprazole for Helicobacter pylori Infection in relation to CYP2C19 Genotype
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Lee SB, Park SJ, Ryu JK, Lee JK, Kim HJ, Bae JS, Jung HS, Park SM
- KMID: 1066037
- Korean J Gastroenterol.
- 2003 Dec;42(6):468-475.
BACKGROUND/AIMS: Genetic polymorphism of cytochrome P450 CYP2C19 influences the efficacy of proton pump inhibitor (PPI) in Helicobacter pylori (H. pylori) eradication therapy. We investigated the difference in the cure... -
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