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Expression and Regulation of Endothelial Nitric Oxide Synthase by Vascular Endothelial Growth Factor in ECV 304 Cells

Park JS, Hong GR, Baek SW, Shin DG, Kim YJ, Shim BS

Nitric oxide (NO) seems to play a pivotal role in the vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. This study was designed to investigate the role and intracellular signal...
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Dysferlin in a hyperCKaemic patient with caveolin 3 mutation and in C2C12 cells after p38 MAP kinase inhibition

Capanni C, Sabatelli , Mattioli E, Ognibene A, Columbaro , Lattanzi G, Merlini L, Minetti C, Maraldi NM, Squarzoni

  • KMID: 1119336
  • Exp Mol Med.
  • 2003 Dec;35(6):538-544.
Dysferlin is a plasma membrane protein of skeletal muscle whose deficiency causes Miyoshi myopathy, limb girdle muscular dystrophy 2B and distal anterior compartment myopathy. Recent studies have reported that dysferlin...
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JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis

Moon DO, Kim MO, Kang CH, Lee JD, Choi YH, Kim GY

The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related...
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Ionizing radiation induces blockade of c-Jun N-terminal kinasedependent cell death pathway in amanner correlated with p21Cip/WAF1 induction in primary cultured normal human fibroblasts

Cho ES, Lee SB, Bae IH, Lee YS, Lee SJ, Um HD

  • KMID: 1093463
  • Exp Mol Med.
  • 2005 Aug;37(4):282-289.
During radiotherapy of cancer, neighboring normal cells may receive sub-lethal doses of radiation. To investigate whether such low levels of radiation modulate normal cell responses to death stimuli, primary cultured...
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