- Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax
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Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG
- KMID: 983956
- Exp Mol Med.
- 2010 Sep;42(9):639-650.
- doi: 10.3858/emm.2010.42.9.063
An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and... -
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- Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts
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Kim BW, Choo HJ, Lee JW, Kim JH, Ko YG
- KMID: 1123769
- Exp Mol Med.
- 2004 Oct;36(5):476-485.
Mitochondrial biogenesis is known to accompany adipogenesis to complement ATP and acetyl-CoA required for lipogenesis. Here, we demonstrated that mitochondrial proteins such as ATP synthase alpha and beta, and cytochrome... -
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- Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
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Koo SH
- KMID: 1705200
- Clin Mol Hepatol.
- 2013 Sep;19(3):210-215.
- doi: 10.3350/cmh.2013.19.3.210
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the... -
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- Activation of PPARgamma induces profound multilocularization of adipocytes in adult mouse white adipose tissues
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Koh YJ, Park BH, Park JH, Han J, Lee IK, Park JW, Koh GY
- KMID: 1099865
- Exp Mol Med.
- 2009 Dec;41(12):880-895.
- doi: 10.3858/emm.2009.41.12.094
We sought to determine the effects of activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male C57BL/6 normal, db/db, and ob/ob mice... -
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- CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation
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Cho B, Cho HM, Kim HJ, Jeong J, Park SK, Hwang EM, Park JY, Kim WR, Kim H, Sun W
- KMID: 2155370
- Exp Mol Med.
- 2014 Jul;46(7):e105.
- doi: 10.1038/emm.2014.36
Mitochondrial functions are essential for the survival and function of neurons. Recently, it has been demonstrated that mitochondrial functions are highly associated with mitochondrial morphology, which is dynamically changed by... -
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- Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells
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Seo SR, Seo JT
- KMID: 1088602
- Exp Mol Med.
- 2009 Apr;41(4):269-276.
- doi: 10.3858/emm.2009.41.4.030
Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic... -
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- Identification and Molecular Characterization of Parkin in Clonorchis sinensis
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Bai X, Kim TI, Lee JY, Dai F, Hong SJ
- KMID: 2381798
- Korean J Parasitol.
- 2015 Feb;53(1):65-75.
- doi: 10.3347/kjp.2015.53.1.65
Clonorchis sinensis habitating in the bile duct of mammals causes clonorchiasis endemic in East Asian countries. Parkin is a RING-between-RING protein and has E3-ubiquitin ligase activity catalyzing ubiquitination and degradation... -
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- Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2
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Kim BE, Lee JH, Kim HS, Kwon OJ, Jeong SW, Kim IK
- KMID: 1123765
- Exp Mol Med.
- 2004 Oct;36(5):444-453.
delta12-Prostaglandin (PG) J2 is known to elicit an anti-neoplastic effects via apoptosis induction. Previous study showed delta12-PGJ2-induced apoptosis utilized caspase cascade through cytochrome c-dependent pathways in HeLa cells. In this... -
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- Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death
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Choi YK, Kim TK, Kim CJ, Lee JS, Oh SY, Joo HS, Foster DN, Hong KC, You S, Kim H
- KMID: 1105272
- Exp Mol Med.
- 2006 Feb;38(1):11-17.
The mitochondrial pathway of swine influenza virus (SIV)-induced apoptosis was investigated using porcine kidney (PK-15) cells, swine testicle (ST) cells, and HeLa cervical carcinoma cells which are known not to... -
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- HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing
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Cho CW, Poo H, Cho YS, Cho MC, Lee KA, Lee SJ, Park SN, Kim IK, Jung YK, Choe YK, Yeom YI, Choe IS, Yoon DY
- KMID: 1081466
- Exp Mol Med.
- 2002 May;34(2):159-166.
Cervical cancer is known to be highly associated with viral oncogene E6 and E7 of human papilloma virus. Down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied.... -
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- Nonalcoholic steatohepatitis: Pathogenesis and treatment
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Park SH
- KMID: 1073326
- Korean J Hepatol.
- 2008 Mar;14(1):12-27.
- doi: 10.3350/kjhep.2008.14.1.12
Nonalcoholic fatty liver disease (NAFLD) is characterized by a wide spectrum of liver damage spanning steatosis, nonalcoholic steatohepatitis (NASH), cryptogenic liver cirrhosis, and even to hepatocellular carcinoma. Investigations in the... -
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