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Germline Variants in MLH1, MSH2, and MSH6 in Korean Patients with Lynch Syndrome

Park KJ, Chang DK, Kim HC, Kim JW

BACKGROUND: The phenotypic and genetic spectrum of Lynch syndrome (LS) seems to differ according to ethnicity. The aim of this study was to investigate the clinical, pathological, and genetic features...
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Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans

Lee SY, Kim DW, Shin YK, Ihn MH, Lee SM, Oh HK, Ku JL, Jeong SY, Lee JB, Ahn S, Won S, Kang SB

PURPOSE: Lynch syndrome, the commonest hereditary colorectal cancer syndrome, is caused by germline mutations in mismatch repair (MMR) genes. Three recently developed prediction models for MMR gene mutations based on...
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Clinical significance of mismatch repair genes immunohistochemical expression of complex endometrial hyperplasia

Han SJ, Kim MK

OBJECTIVE: Women with Lynch syndrome have an increased risk of developing colorectal and gynecologic malignancies such as endometrial cancer. Complex hyperplasia has about a 30% risk of developing into endometrial...
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Hereditary Colon Cancer: Lynch Syndrome

Jang E, Chung DC

  • KMID: 2284180
  • Gut Liver.
  • 2010 Jun;4(2):151-160.
Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is...
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Expression Pattern of DNA Mismatch Repair Genes in Tumors of Microsatellite Mutator Phenotype

Kim JJ, Baek MJ, Kim NG, Kim YH, Kim JE, Kim H, Park C

  • KMID: 1725720
  • Korean J Pathol.
  • 2000 Sep;34(9):609-614.
Microsatellite mutator phenotype (MMP) tumors were reported in a subset of gastrointestinal carcinomas. The molecular pathogenesis of MMP tumors shows defects in the DNA mismatch repair genes, and also many...
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Expression of hMSH2, hMLH1 Protein in Sporadic Colorectal Cancer and Corresponding Normal Tissue

Jung JY, Park DK, Shin JH

  • KMID: 1835109
  • J Korean Soc Coloproctol.
  • 1998 Dec;14(4):709-718.
PURPOSE: DNA mismatch repair gene is responsible for hereditary nonpolyposis colorectal cancer. But it is not well known its role in sporadic colorectal cancer patients. We analysed normal hMSH2, hMLH1...
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