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pH-sensitive Polymeric Micelles for the Effective Delivery of Anti-cancer Drug

Na K

  • KMID: 782863
  • Korean J Gastroenterol.
  • 2007 May;49(5):314-319.
Polymeric micelles from pH-sensitive block copolymers have been designed for targeting tumor acidity or endosomal pH in tumor cells. The micelles are core-shell types formed by self-organization of the blocks...
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Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats

Jang SB, Kim D, Kim SY, Park C, Jeong JH, Kuh HJ, Lee J

The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion...
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Vesicular Cholesterol in Bile with Cholesterol Gallstones

Yoo JG, Ki IH, Lee JW, Kwon KS, Choi W, Lee DH, Cho HG, Kim PS, Kim HG, shin YW, Kim YS, Lee KY, Hong KC

  • KMID: 1548548
  • Korean J Gastroenterol.
  • 1999 Oct;34(4):503-509.
BACKGROUND/AIMS: This study was performed to characterize the mode of cholesterol transport in human gallbladder bile with cholesterol gallstone. METHODS: Subjects were 29 patients with cholesterol gallstone, and controls were...
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Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma

Staroverov SA, Sidorkin V, Fomin AS, Shchyogolev SY, Dykman LA

In this work, we used a preparation of diminazene, which belongs to the group of aromatic diamidines. This compound acts on the causative agents of blood protozoan diseases produced by...
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Advent of Novel Phosphatidylcholine-Associated Nonsteroidal Anti-Inflammatory Drugs with Improved Gastrointestinal Safety

Lim YJ, Dial EJ, Lichtenberger LM

  • KMID: 2053509
  • Gut Liver.
  • 2013 Jan;7(1):7-15.
The mucosa of the gastrointestinal (GI) tract exhibits hydrophobic, nonwettable properties that protect the underlying epithelium from gastric acid and other luminal toxins. These biophysical characteristics appear to be attributable...
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Delivery of Photosensitizers for Photodynamic Therapy

Park S

  • KMID: 782862
  • Korean J Gastroenterol.
  • 2007 May;49(5):300-313.
Photodynamic therapy (PDT) has been used to treat several types of cancer, and comprises intravascular administration of photosensitizer, uptake by cancer cells, and followed by irradiation of light of appropriate...
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An open-label, multicenter, phase I trial of a cremophor-free, polymeric micelle formulation of paclitaxel combined with carboplatin as a first-line treatment for advanced ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG-3016)

Lee SW, Kim YM, Kim YT, Kang SB

OBJECTIVE: This phase I study aimed to determine the maximum tolerated dose (MTD) of Genexol-PM, when combined with carboplatin, as a first-line treatment in patients with advanced ovarian cancer. METHODS: This...
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