- Studies on the protective effect of metallothionein induction against nephrotoxicity of aminoglycoside antibiotic
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Chung HY, Kim JS, Rho YJ, Kim JS, Chung HY
- KMID: 1694796
- Korean J Nephrol.
- 1992 Mar;11(1):40-48.
No abstract available. -
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- The Effect of Metallothionein on the Resistance to Cisplatin in Transfected Mouse NIH/3T3 Cells
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Sohn MH, Kwak JY, Yim CY
- KMID: 2059121
- J Korean Cancer Assoc.
- 1997 Aug;29(4):576-583.
PURPOSE: Metallothionein is an intracellular cystein-rich thiol-containing protein. Increased metallothionein content in tumor cells has been suggested to be a mechanism of resistance to cisplatin. In most of previous studies... -
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- Induction Of Metallothionein And Toxicity In Acute Cadmium Intoxicated Rat
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Min KJ, Park JD, Hong YP, Chang IW
- KMID: 2282633
- Korean J Prev Med.
- 1993 Jun;26(2):231-250.
Thirty five male Sprague-Dawley rats were treated with cadmium chloride solution ranging from 0.2 to 3.2mg CdCl2/kg by intravenous single injection. At 48 hours after administration of cadmium, total cadmium,... -
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- Expression of Metallothionein-1, 2 in Folliculostellate Cells of Rat Anterior Pituitary Gland
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Lee SH, Cho MH, Kim MY, Lee YI, Park KH
- KMID: 1566754
- Korean J Anat.
- 2004 Feb;37(1):61-66.
Metallothionein (MT) family, intracellular zinc binding proteins, has been suggested to play an important regulatory role in zinc metabolism. The present study utilized light and confocal microscopic methods to investigate... -
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- Effect of Sodium Selenite on Metallothionem Induction by the Treatment of Mercuric Chloride to Rats
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Yang YH, Lee HM, Shin DC, Chung Y
- KMID: 1658679
- Korean J Occup Environ Med.
- 1989 Nov;1(2):236-259.
This study was conducted to investigate the metallothionein induction by sodium selenite in mercuric Chloride intoxication. Mercuric chloride of 3.0 mg/kg of body weight was administered simultaneously with sodium selenite... -
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- Biological Indices for Early Detection of Cadmium Poisoning: Significance of Urinary Metallothionein
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Park JD, Hong YP, Chang IW
- KMID: 2141572
- Korean J Occup Environ Med.
- 1997 Jun;9(2):230-243.
Metallothionein(MT) is a low molecular weight protein that is induced as a defence mechanism for cadmium (Cd) toxicity. In present study, urinary MT was determined using a competitive ELISA in... -
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- Multivariable Analysis of Glutathione S-Transferase-pi, P-glycoprotein, and Metallothionein as Indicator of Resistance to Chemotherapy in Epithelial Ovarian Cancer
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Kim KT, Nah DS, Hwang YY, Park MH, Lee SY, Lee SW
- KMID: 1675682
- Korean J Gynecol Oncol Colposc.
- 1996 Jun;7(2):135-144.
BACKGROUND: Several molecular-genetic alterations in epithelial ovarian cancer, including expression of glutathione S-transferase-pi(GST-pi), p-glycoprotein(p-gly), and metallothionein(MT), have been associated with drug resistance and poor prognosis. To deterrmine the importance of... -
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- Biological Index for Cadmium Exposure: Assay of Metallothionein by Competitive ELISA
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Park JD, Lee WS, Kong Y, Hong YP, Chang IW
- KMID: 2027939
- Korean J Occup Environ Med.
- 1996 Sep;8(2):258-271.
Metallothionein (MT) is a cadmium binding protein that played major' roles in protective mechanism for cadmium toxicity. In the present study, competitive ELISA was established to assay the MT expression... -
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- Role of Inducibility of Superoxide Dismutases and Metallothionein of Mouse Lungs by Paraquat in Aging
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Lee TB, Park YH, Choi CH
- KMID: 2160200
- Tuberc Respir Dis.
- 2001 May;50(5):579-590.
- doi: 10.4046/trd.2001.50.5.579
BACKGROUND: The aging process may be induced, at least in part, by reactive oxygen species(ROS). It has been though that the lung could be a good source of ROS because... -
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- Effect of Dexamethasone and Epinephrine on Metallothionein Level in the Perfused Rat Liver
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Lee HS, Oh SH
- KMID: 692893
- Yonsei Med J.
- 1980 Jun;21(1):18-23.
- doi: 10.3349/ymj.1980.21.1.18
The effect of dexamethasone (10(-5)M) and epinephrine (10(-6)M) on the biosynthesis of metallothionein (MT) in the perfused rat liver was investigated. MT synthesis was determined by measuring the incorporation of... -
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- Immunohistochemical Study of Metallothionein Expression in Colonic Adenocarcinoma: Correlation with p53, Topoisomerase II-alpha Expression and Apoptosis
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Park YK, Lee DI, Lee TJ, Yoo JH
- KMID: 2096252
- J Korean Surg Soc.
- 2005 May;68(5):388-395.
PURPOSE: Although immunohistochemically detectable metallothionein (MT) overexpression has been described in proliferation epithelial tumor cells, the clinical significance of the expression remains to be elucidated. Therefore, the present article is... -
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- Effect of Chlorella intake on Cadmium metabolism in rats
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Shim JA, Son YA, Park JM, Kim MK
- KMID: 2313372
- Nutr Res Pract.
- 2009 Mar;3(1):15-22.
This study was performed to investigate the effect of chlorella on cadmium (Cd) toxicity in Cd- administered rats. Sixty male Sprague-Dawley rats (14 week-old) were blocked into 6 groups. Cadmium... -
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- Effect of Vitamin E on Cadmium Accumulation and Excretion in Chronic Cadmium Poisoned Rats
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Kim MJ, Hong JH, Rhee SJ
- KMID: 2269685
- Korean J Nutr.
- 2003 Sep;36(7):691-698.
The purpose of this study was to investigate the effect of vitamin E on the cadmium accumulation in body, cadmium excretion and detoxification functions in chronic cadmium poisoned rats. Sprague-Dawley... -
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- Metallothionein induction and its protective effect in liver and kidney of rats exposed to cadmium chloride
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Kim NS, Lee JH, Koh DH, Ki NS, Hwang ID
- KMID: 2282570
- Korean J Prev Med.
- 1991 Sep;24(3):287-304.
Tolerance to several toxic effects of cadmium, including lethality has been shown following pretreatment with cadmium and zinc. This study was designed to determine if tolerance also develops to Cd-induced... -
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- Effect of metal ions on the stability of metallothionein in the degradation by cellular fractions in vitro
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Hahn SH, Yoo OJ, Gahl WA
- KMID: 755115
- Exp Mol Med.
- 2001 Mar;33(1):32-36.
Metallothioneins (MT), small molecular weight metal binding proteins are known to play an important protective role against heavy metal toxicity, either as antioxidants or pre-oxidants. However, the mode of metabolic... -
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- Inducibility of superoxide dismutases and metallothionein in the liver and kidney of mice by paraquat with age
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Lee TB, Park YH, Min YD, Choi CH
- KMID: 1985005
- Korean J Med.
- 2001 Oct;61(4):430-438.
BACKGROUND: A number of theories have been proposed to explain the nature of aging process. Unfortunately, there is so far no theory that can completely explain all aging processes. In... -
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- Induction of Metallothionein and Manganese-Containing Superoxide Dismutase by Paraquat in Peripheral White Blood Cells of Patients with Gastric Cancer
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Moon SP, Choi CH, Cha YJ, Chang JH, Kim CY, Min YD
- KMID: 2209327
- J Korean Surg Soc.
- 2000 Dec;59(6):751-758.
PURPOSE: It is known that deficiency of metallothionein (MT) and manganese-containing superoxide dismutase (Mn-SOD), scavengers of reactive oxygen species, results in aging and carcinogenesis by inducing DNA damage. Paraquat can... -
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- Effect of Grape Intake on Cadmium Metabolism of Rats during Aging
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Choi SJ, Kim MK
- KMID: 2269707
- Korean J Nutr.
- 2003 Dec;36(10):997-1012.
This study was carried out to investigate the effect of whole grape, grape pomace and grape juice intake on cadmium (Cd) metabolism during aging in thirteen-month-old Sprague-Dawley male rats. One... -
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- Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model
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Heo JH, Lee SH, Chang KH, Han EH, Lee SG, Choi DW, Kim SW
- KMID: 1502514
- Biomol Ther.
- 2013 Mar;21(2):126-131.
Neuropathic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that... -
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- Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation
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Kim JR, Ryu HH, Chung HJ, Lee JH, Kim SW, Kwun WH, Baek SH, Kim JH
- KMID: 1111409
- Exp Mol Med.
- 2006 Apr;38(2):162-172.
People with upper body or visceral obesity have a much higher risk of morbidity and mortality from obesity-related metabolic disorders than those with lower body obesity. In an attempt to... -
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