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Bioprospecting of Endophytic Fungi as Promising Anti-MRSA Agents

Wei YM, Tan JS, Tang HW, Tong WY, Leong CR, Tan WN

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are...
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Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris

Huang Y, Liu L, Chen L, Zhou L, Xiong X, Deng Y

Background: The gut microbial dysbiosis and gender differences in the pathogenesis of acne vulgaris have long been postulated respectively. However, there was no data about a genderrelated discrepancy in gut...
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Draft Genome Sequence of Xylaria grammica EL000614, a Strain Producing Grammicin, a Potent Nematicidal Compound

Park SY, Jeon J, Kim JA, Jeon MJ, Yu NH, Kim S, Park AR, Kim JC, Lee Y, Kim Y, Choi ED, Jeong MH, Lee YH, Kim S

An endolichenic fungus,Xylaria grammica strain EL000614, showed strong nematicidal effects against plant pathogenic nematode, Meloidogyne incognita by producing grammicin. We report genome assembly of X. grammica EL000614 comprised of 25...
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Draft Genome Sequence of Xylaria grammica EL000614, a Strain Producing Grammicin, a Potent Nematicidal Compound

Park SY, Jeon J, Kim JA, Jeon MJ, Yu NH, Kim S, Park AR, Kim JC, Lee Y, Kim Y, Choi ED, Jeong MH, Lee YH, Kim S

An endolichenic fungus, Xylaria grammica strain EL000614, showed strong nematicidal effects against plant pathogenic nematode, Meloidogyne incognita by producing grammicin. We report genome assembly of X. grammica EL000614 comprised of 25...
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Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine

Deyrup ST, Stagnitti NC, Perpetua MJ, Wong-Deyrup SW

Traditional Chinese medicine (TCM) was the primary source of medical treatment for the people inhabiting East Asia for thousands of years. These ancient practices have incorporated a wide variety of...
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Chemicals Constituents from Leaves of Diospyros iturensis (Gürke) Letouzey & F. White and their Biological Activities

Feumo Feusso HM, Dongmo Jdd, Djomkam HLM, Akak CM, Lateef M, Ahmed A, Blaise Azebaze AG, Kamdem Waffo AF, Shaiq Ali M, Vardamides JC

he chemical investigation of the methanolic crude extract of leaves of Diospyros iturensis gave us 15 known secondary metabolites identified as mixture of α-amyrenone (1) and β-amyrenone (2), β-amyrin (3),...
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Global Regulators to Activate Silent Biosynthetic Gene Clusters

Shim SH

Genome mining has recently emerged as a powerful strategy to discover novel microbial secondary metabolites. However, more than 50% of biosynthetic gene clusters are not transcribed under standardized laboratory culture...
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Mushrooms: An Important Source of Natural Bioactive Compounds

Ha JW, Kim J, Kim H, Jang W, Kim KH

Mushrooms are known for their various attributes in the fields of nutrition and therapeutics. With exceptional taste, aroma, and nutritional value, they are considered ‘functional food’-improving health and providing nutritional...
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Metabolomics profiling in hypertension and blood pressure regulation: a review

Onuh JO, Aliani M

Hypertension is a chronic health condition in which blood pressure is usually elevated beyond normal levels. It can progress with serious complications if left undetected and untreated. Incidence of hypertension...
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Endophytic Fungi Inhabiting Medicinal Plants and Their Bioactive Secondary Metabolites

Lee C, Shim SH

Endophytes are defined as microorganisms that spend part of lifetime interior of plant tissues without causing negative effects. They have been used for agricultural purpose, biofuel production, bioremediation, medication, etc....
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Specific urinary metabolites in canine mammary gland tumors

Marcela VR, Peter O, Aneta S, Radka T, Zuzana K

The identification of biomarkers that distinguish diseased from healthy individuals is of great interest in human and veterinary fields. In this research area, a metabolomic approach and its related statistical...
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Identification and Characterization of Two New S-Adenosylmethionine-Dependent Methyltransferase Encoding Genes Suggested Their Involvement in Stipe Elongation of Flammulina velutipes

Huang Q, Mukhtar I, Zhang Y, Wei Z, Han X, Huang R, Yan J, Xie B

Two new SAM-dependent methyltransferase encoding genes (fvsmt1 and fvsmt2) were identified from the genome of Flammulina velutipes. In order to make a comprehensive characterization of both genes, we performed in...
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Association between Abdominal Obesity and Oxidative Stress in Korean Adults

Na IJ, Park JS, Park SB

BACKGROUND: Obesity causes several changes in the body and is associated with both inflammation and oxidative stress. However, the relationship between abdominal obesity, diacron-reactive oxygen metabolites (d-ROMs), and biological antioxidant...
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Evaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Study

Erbay MF, Zayman EP, Erbay LG, Ãœnal S

OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study evaluated the antidepressant effect of rTMS and examined how it affected N-asetyl aspartate...
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Bioactive Compound Produced by Endophytic Fungi Isolated From Pelargonium sidoides Against Selected Bacteria of Clinical Importance

Manganyi M, Tchatchouang CDK, Regnier T, Bezuidenhout CC, Ateba CN

Endophytic fungi have the ability to live inside the host plant tissues without causing neither symptoms of diseases/or harm. Opportunistic infections are accountable for majority of the outbreaks, thereby putting...
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Association between urinary phthalate metabolites and obesity in adult Korean population: Korean National Environmental Health Survey (KoNEHS), 2012–2014

Kang Y, Park J, Youn K

BACKGROUND: Phthalate is a chemical that is commonly used as a plasticizer in processing plastic products and as a solvent in personal care products. Although previous experimental studies have reported...
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Metabolites profiling and hypolipidemic/hypocholesterolemic effects of persimmon (Diosyros kaki Thumb.) by different processing procedures: in vitro and in vivo studies

Park SY, Oh EK, Lim Y, Shin JY, Jung HA, Park SY, Lee JH, Choe JS, Kwon O

PURPOSE: Our previous study demonstrated that persimmon (Diospyros kaki Thumb.) at different stages of ripening provided different protective effects against high-fat/cholesterol diet (HFD)-induced dyslipidemia in rats. In this study, we...
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Evaluation of Stability of Thiopurine Metabolites Using a Validated LC-MS/MS Method

Yoo IY, Lee K, Ji OJ, Woo HI, Lee SY

Measurement of thiopurine metabolites is helpful to monitor adverse effects and assess compliance in patients on thiopurine treatment. The purpose of this study was to develop and validate an analytical...
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Regulation of Allergic Immune Responses by Microbial Metabolites

Park HJ, Lee SW, Hong S

Emerging evidence demonstrates that the microbiota plays an essential role in shaping the development and function of host immune responses. A variety of environmental stimuli, including foods and commensals, are...
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Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure

Kamo T, Akazawa H, Suzuki JI, Komuro I

Patients with heart failure (HF) have structural and functional changes of the gut as a result of microcirculatory disturbances. A disrupted gut epithelial barrier may lead to translocation of microbial...
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