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Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study

Yang JH, Kweon SS, Lee YH, Choi SW, Ryu SY, Nam HS, Park KS, Kim HY, Shin MH

Background: Several studies have reported conflicting results regarding the relationship between alcohol consumption and cortisol levels. However, the causality between alcohol consumption and cortisol levels has not been evaluated. Methods: This...
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The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study

Lee YH, Song GG

Objective: The aim of this study was to examine if the intestinal microbiome is causally correlated with osteoarthritis (OA) incidence. Methods: A two-sample Mendelian randomization (MR) study was conducted using...
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Clinical and genetic relationships between the QTc interval and risk of a stroke among atrial fibrillation patients undergoing catheter ablation

Hong M, Chun K, Hwang I, Yu H, Kim T, Uhm J, Joung B, Lee M, Pak H

Background and objectives: A prolonged QTc interval is associated with an increased risk of a stroke or atrial fibrillation (AF). However, its direct causal relationship with AF associated a stroke...
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The Uric Acid and Gout have No Direct Causality With Osteoarthritis: A Mendelian Randomization Study

Lee YH, Song GG

OBJECTIVE: To examine whether uric acid level or gout is causally associated with the risk of osteoarthritis. METHODS: We performed a two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW), MR-Egger...
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Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses

Spiller W, Jung KJ, Lee JY, Jee SH

Cardiovascular disease (CVD) is considered a primary driver of global mortality and is estimated to be responsible for approximately 17.9 million deaths annually. Consequently, a substantial body of research related...
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Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease

Lee SH, Lee JY, Kim Gh, Jung KJ, Lee S, Kim HC, Jee SH

Background and Objectives: Associations between blood lipids and risk of ischemic heart disease (IHD) have been reported in observational studies. However, due to confounding and reverse causation, observational studies are...
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Genetically Mediated Lipid Metabolism and Risk of Insulin Resistance: Insights from Mendelian Randomization Studies

Bu SY

Dysregulated lipid metabolism, characterized by higher levels of circulating triglycerides, higher levels of small, low density lipoprotein, and accumulation of intracellular lipids, is linked to insulin resistance and related complications...
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Mendelian Randomization Analysis in Observational Epidemiology

Lee K, Lim CY

Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease....
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Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea

Shin MJ, Cho Y, Davey Smith G

Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme...
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