- Mendelian Randomization Analysis in Observational Epidemiology
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Lee K, Lim CY
- KMID: 2458376
- J Lipid Atheroscler.
- 2019 Sep;8(2):67-77.
- doi: 10.12997/jla.2019.8.2.67
Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease.... -
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- Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses
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Spiller W, Jung KJ, Lee JY, Jee SH
- KMID: 2468035
- Korean Circ J.
- 2020 Feb;50(2):91-111.
- doi: 10.4070/kcj.2019.0293
Cardiovascular disease (CVD) is considered a primary driver of global mortality and is estimated to be responsible for approximately 17.9 million deaths annually. Consequently, a substantial body of research related... -
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- Causal Association between Rheumatoid Arthritis with the Increased Risk of Type 2 Diabetes: A Mendelian Randomization Analysis
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Lee YH, Song GG
- KMID: 2442024
- J Rheum Dis.
- 2019 Apr;26(2):131-136.
- doi: 10.4078/jrd.2019.26.2.131
OBJECTIVE: This study aimed to examine whether rheumatoid arthritis (RA) is causally associated with type 2 diabetes (T2D). METHODS: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted... -
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- The Uric Acid and Gout have No Direct Causality With Osteoarthritis: A Mendelian Randomization Study
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Lee YH, Song GG
- KMID: 2471949
- J Rheum Dis.
- 2020 Apr;27(2):88-95.
- doi: 10.4078/jrd.2020.27.2.88
OBJECTIVE: To examine whether uric acid level or gout is causally associated with the risk of osteoarthritis. METHODS: We performed a two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW), MR-Egger... -
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- Genetically Mediated Lipid Metabolism and Risk of Insulin Resistance: Insights from Mendelian Randomization Studies
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Bu SY
- KMID: 2458378
- J Lipid Atheroscler.
- 2019 Sep;8(2):132-143.
- doi: 10.12997/jla.2019.8.2.132
Dysregulated lipid metabolism, characterized by higher levels of circulating triglycerides, higher levels of small, low density lipoprotein, and accumulation of intracellular lipids, is linked to insulin resistance and related complications... -
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- Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
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Shin MJ, Cho Y, Davey Smith G
- KMID: 2419072
- Yonsei Med J.
- 2017 Jul;58(4):689-696.
- doi: 10.3349/ymj.2017.58.4.689
Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme... -
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