- Prolonged semen incubation alters the biological characteristics of human spermatozoa
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Beigi SAD, Khalili MA, Nabi A, Hosseini M, Sarcheshmeh AA, Sabour M
- KMID: 2540238
- Clin Exp Reprod Med.
- 2022 Dec;49(4):270-276.
- doi: 10.5653/cerm.2022.05435
Objective: The present study assessed the biological characteristics of human spermatozoa at different time intervals (0, 1, 1.5, and 2 hours) after incubation at 37°C. Methods: Twenty-five normozoospermic semen samples were... -
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- Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal
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Lee JH, Wu WH, Huang XY, Jun JY, Choi S
- KMID: 2507118
- J Neurogastroenterol Motil.
- 2020 Oct;26(4):521-528.
- doi: 10.5056/jnm20064
Background/Aims To investigate an effect of ML204 (an inhibitor of transient receptor potential canonical 4 and 5 [TRPC4/5] channels) on interstitial cells of Cajal (ICCs) and therefore determine whether TRPC4/5 channels... -
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- Effect of Cyclosporine A-induced Senescence on Cultured Human Corneal Endothelial Cells
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Jang YK, Chung TY, Shin YJ
- KMID: 2506473
- J Korean Ophthalmol Soc.
- 2020 Sep;61(9):999-1009.
- doi: 10.3341/jkos.2020.61.9.999
Purpose: To investigate the in vitro effect of cyclosporine A (CsA)-induced senescence on human corneal endothelial cells (HCECs). Methods: HCECs were cultured and incubated with 0-100 µM CsA. Senescence-associated β–galactosidase (SA-β-gal)... -
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- Lithium Stabilizes the Mood of Bipolar Patients by Depolarizing the Neuronal Membrane Via Quantum Tunneling through the Sodium Channels
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Qaswal AB
- KMID: 2502146
- Clin Psychopharmacol Neurosci.
- 2020 May;18(2):214-218.
- doi: 10.9758/cpn.2020.18.2.214
Objective: Lithium is used as first line in treating bipolar patients to stabilize their mood. However, the exact mechanism of lithium is not yet established. One of the proposed mechanisms... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells
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- KMID: 2470118
- Korean J Vet Res.
- 2019 Dec;59(4):195-199.
- doi: 10.14405/kjvr.2019.59.4.195
Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,... -
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- Cyanidin-3-glucoside inhibits amyloid β₂₅₋₃₅-induced neuronal cell death in cultured rat hippocampal neurons
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Yang JS, Jeon S, Yoon KD, Yoon SH
- KMID: 2430091
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):689-696.
- doi: 10.4196/kjpp.2018.22.6.689
Increasing evidence implicates changes in [Ca²âº]i and oxidative stress as causative factors in amyloid beta (Aβ)-induced neuronal cell death. Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect... -
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- Nobiletin attenuates neurotoxic mitochondrial calcium overload through K⺠influx and ΔΨ(m) across mitochondrial inner membrane
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Lee JH, Amarsanaa , Wu J, Jeon SC, Cui Y, Jung SC, Park DB, Kim SJ, Han SH, Kim HW, Rhyu IJ, Eun SY
- KMID: 2410095
- Korean J Physiol Pharmacol.
- 2018 May;22(3):311-319.
- doi: 10.4196/kjpp.2018.22.3.311
Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium... -
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- A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca2+ Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat
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Lee JH, Ha JM, Leem CH
- KMID: 2285581
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):373-382.
- doi: 10.4196/kjpp.2015.19.4.373
Fura-2 analogs are ratiometric fluoroprobes that are widely used for the quantitative measurement of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which... -
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- Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
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Li M, Ouyang W, Wu X, Zheng Y, Wei Y, An L
- KMID: 2155618
- J Vet Sci.
- 2014 Sep;15(3):353-359.
- doi: 10.4142/jvs.2014.15.3.353
Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by... -
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- Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca2+ Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells
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Perveen S, Yang JS, Ha TJ, Yoon SH
- KMID: 2285523
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):297-305.
- doi: 10.4196/kjpp.2014.18.4.297
Flavonoids have an ability to suppress various ion channels. We determined whether one of flavonoids, cyanidin-3-glucoside, affects adenosine 5'-triphosphate (ATP)-induced calcium signaling using digital imaging methods for intracellular free Ca2+... -
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- Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage
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Kim KC, Piao MJ, Zheng J, Yao CW, Cha JW, Kumara MH, Han X, Kang HK, Lee NH, Hyun JW
- KMID: 2170623
- Biomol Ther.
- 2014 Jul;22(4):301-307.
Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G... -
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- Mycophenolic acid mediated mitochondrial membrane potential transition change lead to T lymphocyte apoptosis
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Choi SJ, Lee HK, Kim NH, Chung SY
- KMID: 1445743
- J Korean Surg Soc.
- 2011 Oct;81(4):235-241.
- doi: 10.4174/jkss.2011.81.4.235
PURPOSE: This study demonstrated that apoptosis induced by mycophenolic acid (MPA) is mediated by mitochondrial membrane potential transition (MPT) changes in Jurkat cells. METHODS: Cell viability and MPT changes were measured... -
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- Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells
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Wang MF, Liao YF, Hung YC, Lin CL, Hour TC, Lue KH, Hung HC, Liu GY
- KMID: 1104388
- Exp Mol Med.
- 2011 Apr;43(4):189-196.
- doi: 10.3858/emm.2011.43.4.023
Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising chemopreventive agent. In this... -
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- Electrophysiological Characteristics of Human Colon Circular Muscle
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Choe EK, Ryoo SB, Moon SH, Moon JS, Park KJ
- KMID: 2198805
- J Korean Soc Coloproctol.
- 2010 Apr;26(2):105-110.
- doi: 10.3393/jksc.2010.26.2.105
PURPOSE: Interstitial cells of Cajal (ICC) play a core function in colonic motility as a pacemaker by regulating the slow wave. We intended to investigate the electrophysiological characteristics of the... -
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- Mitochondrial Dysfunction and Apoptosis Related Gene Expression in A beta(25-35)-Treated Human Neuroblastoma Cell Line, SK-N-SH
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Choi YS, Kim SH
- KMID: 2338986
- J Korean Geriatr Soc.
- 2009 Sep;13(3):142-151.
BACKGROUND: Mitochondrial dysfunction plays an important role in Abeta-induced neuronal toxicity in Alzheimer's disease (AD). We measured the membrane potentials of mitochondria (delta psim) and assessed the genetic expressions of... -
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- Synthesis of (4-[18F]Fluorophenyl)triphenylphosphonium as a Mitochondrial Voltage Sensor for PET
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Kim DY, Yu KH, Bom HS, Min JJ
- KMID: 1910722
- Nucl Med Mol Imaging.
- 2007 Dec;41(6):561-565.
PURPOSE: Lipophilic cations including tetraphenylphosphonium (TPP) salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes, resulting in accumulation in mitochondria in response to the negative inner transmembrane potentials.... -
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- Hydrogenosomal activity of Trichomonas vaginalis cultivated under different iron conditions
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Kim YS, Song HO, Choi IH, Park SJ, Ryu JS
- KMID: 1088770
- Korean J Parasitol.
- 2006 Dec;44(4):373-378.
- doi: 10.3347/kjp.2006.44.4.373
To evaluate whether iron concentration in TYM medium influence on hydrogenosomal enzyme gene expression and hydrogenosomal membrane potential of Trichomonas vaginalis, trophozoites were cultivated in irondepleted, normal and iron-supplemented TYM... -
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- Study on the Mitochondrial Dysfunction by p53 Regulation in Ceramide-induced Neuronal Cell Death
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Lee DY, Lee HJ, Noh YH, Yun JY, Han IS, Chung YH, Kim KY, Kim SS, Lee WB
- KMID: 1512990
- Korean J Phys Anthropol.
- 2006 Mar;19(1):49-59.
Ceramide induces cell death in a dose- and time-dependent manner in neuroblastoma SK-N-SH cells. To investigate the mechanism of SK-N-SH cell death by C2-ceramide, morphological features and Hoechst 33258 staining... -
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- Studies on Signal Transduction Mechanism of Alcohol-induced Neuronal Cell Death and Protective Effect
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Lee DY, Kim SS, Kim KY, Lee WB, Kim DK, Kim KH, Jung HY, Lee SH
- KMID: 1517132
- Korean J Phys Anthropol.
- 2004 Mar;17(1):31-43.
Excessive use of alcohol is a serious problem in our society and induces various, severe alcohol related diseases. The cytotoxicities of ethanol are still largely unknown. We studied the molecular... -
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