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Melatonin and Alzheimer’s Disease: A Mini-Review

Um YH, Lim HK

Melatonin is a hormone with neuroregulatory, antioxidant and anti-inflammatory properties. Its benevolent effects on Alzheimer’s disease (AD) has been replicated in both animal models and clinical studies. Melatonin was effective...
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Melatonin Protects Chronic Kidney Disease Mesenchymal Stem/Stromal Cells against Accumulation of Methylglyoxal via Modulation of Hexokinase-2 Expression

Go G, Yoon YM, Yoon S, Lee G, Lim JH, Han SY, Lee SH

Treatment options for patients with chronic kidney disease (CKD) are currently limited; therefore, there has been significant interest in applying mesenchymal stem/stromal cell (MSC)-based therapy to treat CKD. However, MSCs...
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Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats

Yang HJ, Kim MJ, Kim SS, Cho YW

The sleep-wake cycle is regulated by the alternating activity of sleep- and wake-promoting neurons. The dorsal raphe nucleus (DRN) secretes 5-hydroxytryptamine (5-HT, serotonin), promoting wakefulness. Melatonin secreted from the pineal...
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The Effect of Laughter Therapy on Sleep in Community-dwelling Elders with Sleep Disorders

Lee YS, Park H

Purpose: The purpose of this study was to examine the effect of laughter therapy on the quality and quantity of sleep in elders with sleep disorders. Methods: This was a quasi-experimental...
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Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells

Lee JH, Yoo YM, Lee B, Jeong S, Tran DN, Jeung EB

Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This...
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Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamopituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats

Kadir ER, Imam A, Olajide OJ, Ajao MS

Bisphenol A is a chemical used primarily as a monomer in the production of polycarbonate plastics and epoxy resins. It is a synthetic chemical compound that is produced in billions...
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Relationship among Cognition, Sleep Patterns, Salivary Melatonin Level and Sleep Disorder Inventory of Older Adults in Nursing Homes

Shim H, Sohng KY

Purpose: The purpose of this study was to investigate sleep quality in older adults in nursing home with objective data collection. Methods: Participants included 74 older adults in nursing homes in...
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Effects of Organic Light-Emitting Diodes on Circadian Rhythm and Sleep

Jo H, Park HR, Choi SJ, Lee SY, Kim SJ, Joo EY

Objective Organic light-emitting diodes (OLEDs) emit less blue light than traditional light-emitting diodes (LEDs), and we previously found that early-night OLED light exposure (LE) delays the melatonin phase by less...
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Association between the Arylalkylamine N-Acetyltransferase (AANAT) Gene and Seasonality in Patients with Bipolar Disorder

Yang SY, Hong KS, Cho Y, Cho EY, Choi Y, Kim Y, Park T, Ha K, Baek JH

Objective Bipolar disorder (BD) is complex genetic disorder. Therefore, approaches using clinical phenotypes such as biological rhythm disruption could be an alternative. In this study, we explored the relationship between...
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Recent Update on Treatment and Management of Rapid Eye Movement Sleep Behavior Disorder

Byun JI, Shin WC

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia that is characterized by dream-enactment behavior, which can often result in sleep related injury. RBD is strongly associated with neurodegenerative...
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Changes Caused by the Melatonergic System in Young Patients with Mood Disorders: A Literature Review

Lee JH, Moon E

The abnormalities caused by the melatonergic system have been associated with psychiatric disorders, such as Alzheimer’s dementia and schizophrenia, as well as with the pathogenesis of mood disorders. Abnormal melatonin...
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Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease

Lin CH, Chiu CC, Lane HY

Objective: Melatonin has been considered to have an essential role in the pathophysiology of Alzheimer’s disease (AD) for its regulatory function on circadian rhythm and interaction with glutamate for the...
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Effect of Haloperidol and Risperidone on Serum Melatonin and GAP-43 in Patients with Schizophrenia: A Prospective Cohort Study

Maiti R, Mishra BR, Jena M, Mishra A, Nath S

Objective: Serum melatonin, a biomarker of circadian rhythm, can upregulate Growth-associated protein 43 (GAP-43) which is involved in neural regeneration and plasticity. The present study was conducted to investigate the...
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A Sensitive and Specific Liquid ChromatographyTandem Mass Spectrometry Assay for Simultaneous Quantification of Salivary Melatonin and Cortisol: Development and Comparison With Immunoassays

Shin S, Oh H, Park HR, Joo EY, Lee SY

Melatonin and cortisol are clinically important for diagnosing sleep and mood disorders. We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/ MS) assay for simultaneous measurement of salivary melatonin and...
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Therapeutic Effects of Prolonged Release Melatonin (Circadin® ) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old

Park MJ, Seo SY, Park HJ, Park JH, Lim MY, Park NC

Objectives: Bladder storage symptoms including nocturia is the most common cause of sleep disturbance in all age groups. Sleep disturbance is also a main cause of nocturia so that sleep recovery...
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Effect of cypermethrin on the postnatal development of the medulla oblongata and the possible protective role of melatonin in albino rats

Al-Gholam MA, Issa NM

Previous studies have shown that cypermethrin (CYP), a broad spectrum pesticide has a teratogenic effect on rat offspring born to an exposed dam with no information on its effect on...
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Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Lamtai M, Ouakki S, Zghari O, Hamzaoui AE, Benmhammed H, Azirar S, Hessni AE, Mesfioui A, Ouichou A

The present work is carried out to explore the neuroprotective potential of Melatonin(Mel), on Ni-induced neurobehavioral, biochemical and histological alterations in male and female rats. The rats were intraperitoneally administered...
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Measurement of Circadian Rhythms in the Research of Psychiatric Disorders

Kim SY, Moon E, Jeong HJ

  • KMID: 2508331
  • J Korean Soc Biol Ther Psychiatry.
  • 2020 Oct;26(3):177-183.
The circadian rhythms have been gradually important in psychiatric field. Several studies have shown that major psychiatric disorders, such as schizophrenia, bipolar disorders, and dementia, were highly associated with the...
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A Review on the Effects of Melatonin on Fetal Protection during Pregnancy with Intrauterine Inflammation

Kim JM, Lee JY

Intrauterine inflammation is defined as the inflammation of the chorion, amnion, and placenta. Untreated inflammation increases the risk of fetal inflammatory response syndrome, which may result in multiorgan diseases involving...
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The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats

Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M

Objectives: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role...
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