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Influence of the sequence variations of the HLA-DR promoters derived from human melanoma cell lines on nuclear protein binding and promoter activity

Lee TJ, Kim SJ, Park JH

In previous studies we reported that the expression of HLA-DR on melanoma cell lines was differentially modulated by IFN- gamma and that the transcription rate was responsible for this differential...
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Aberrant expression of p53 gene product in malignant melanoma

Rhim KJ, Hong SI, Hong WS, Lee SY, Lee DS, Jang JJ

According to the current concept of carcinogenesis, the alterations of p53 tumor suppressor gene have been the most frequently detected in both human cancer cell lines and cancer tissues freshly...
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Efficient amplification of melanoma-specific CD8+ T cells using artificial antigen presenting complex

Chang J

  • KMID: 1115936
  • Exp Mol Med.
  • 2006 Dec;38(6):591-598.
In vitro large amplification of tumor-specific cytotoxic T lymphocytes (CTLs) and adoptive transfer of these cells is one of the most promising approaches to treat malignant diseases in which an...
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Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line

Flickinger I, Rutgen BC, Gerner W, Calice I, Tichy A, Saalmuller A, Kleiter M

To evaluate radiosensitivity and the effects of radiation on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the canine oral melanoma cell line, TLM 1, cells...
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Molecular analysis of HLA-DR gene expression induced by IFN-gamma in malignant melanoma cell lines

Lee JL, Kim YH, Lee JM, Kim JD, Kim SJ, Park JH

Human leukocyte antigen (HLA) class II molecules are polymorphic cell surface glycoproteins that are crucial for the cellular interaction in immune response. The expression of class II molecules...
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Mechanism of Immune Response During Immunotherapy

Panelli MC, Nagorsen D, Wang E, Monsurro V, Jin P, Katia Z, Smith K, Ngalame Y, Marincola

Tumor immunology embraces an extensive array of biological phenomena that include interactions between neoplastic cells and the innate and adaptive immune response. Among immune cells, T cells have taken the...
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